Zobrazeno 1 - 10
of 94
pro vyhledávání: '"J. Cee"'
Autor:
Richard L. Kendall, Robert Radinsky, Stephanie Geuns-Meyer, Vinod F. Patel, Isabelle Dussault, Mary Stanton, Annette Bak, Laurie B. Schenkel, Karina Romero, Philip R. Olivieri, Hanh Nho Nguyen, Brian L. Hodous, Holly L. Deak, Victor J. Cee, Sandra Ross, Patricia McElroy, Patrick Eden, Beth Ziegler, Grace Chung, Tammy L. Bush, Marc Payton
Supplementary Methods, Figures 1-5 from Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7147a5f5dbda291c8291002c611e48dd
https://doi.org/10.1158/0008-5472.22387907.v1
https://doi.org/10.1158/0008-5472.22387907.v1
Autor:
Adam Birkholz, David J. Kopecky, Laurie P. Volak, Michael D. Bartberger, Yuping Chen, Christopher M. Tegley, Tara Arvedson, John D. McCarter, Christopher Fotsch, Victor J. Cee
Publikováno v:
Journal of Medicinal Chemistry. 63:11602-11614
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a87dd68f57c5dc8709d8ccacc28c2296
https://doi.org/10.1021/acs.jmedchem.0c00749
https://doi.org/10.1021/acs.jmedchem.0c00749
Autor:
Jude R. Canon, Ashley Callinan, Sarah Bradley, Laurie Wang, Mackenzie Kui, Ariel Wein, Gabriele Sulli, Peter Buchowiecki, Fang-Tsao Hong, Miles Kubota, Mary Walton, Victor J. Cee
Publikováno v:
Cancer Research. 83:LB318-LB318
Sumoylation is a reversible post-translational modification of proteins by small ubiquitin-like modifier (SUMO) that regulates protein function and contributes to cellular response to stress. Sumoylation is an essential pathway for all cells and is i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29a9c968056ed63643aa28630abd9091
https://doi.org/10.1158/1538-7445.am2023-lb318
https://doi.org/10.1158/1538-7445.am2023-lb318
Autor:
Jessica E. Burch, Austin G. Smith, Seb Caille, Shawn D. Walker, Ryan Wurz, Victor J. Cee, Jose Rodriguez, D. Gostovic, Kyle Quasdorf, Hosea M. Nelson
The application of microcrystal electron diffraction (microED) to a variety of pharmaceutical compounds is reported. The examples and work detailed showcase the utility of microED as a routine technique for the rapid collection, analysis, and generat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab3970fb55ec2c8c1965f9bc877a7478
https://doi.org/10.26434/chemrxiv-2021-h3tqz
https://doi.org/10.26434/chemrxiv-2021-h3tqz
Autor:
Jose A. Rodriguez, Hosea M. Nelson, Seb Caille, Jessica E. Burch, D. Gostovic, Victor J. Cee, Ryan Wurz, Austin G. Smith, Shawn D. Walker, Kyle Quasdorf
The application of microcrystal electron diffraction (microED) to a variety of pharmaceutical compounds is reported. The examples and work detailed showcase the utility of microED as a routine technique for the rapid collection, analysis, and generat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b6ac508fbe979fb0dba0c85c7c73694
https://doi.org/10.33774/chemrxiv-2021-h3tqz
https://doi.org/10.33774/chemrxiv-2021-h3tqz
Autor:
Brian A. Lanman, Jennifer R. Allen, John G. Allen, Albert K. Amegadzie, Kate S. Ashton, Shon K. Booker, Jian Jeffrey Chen, Ning Chen, Michael J. Frohn, Guy Goodman, David J. Kopecky, Longbin Liu, Patricia Lopez, Jonathan D. Low, Vu Ma, Ana E. Minatti, Thomas T. Nguyen, Nobuko Nishimura, Alexander J. Pickrell, Anthony B. Reed, Youngsook Shin, Aaron C. Siegmund, Nuria A. Tamayo, Christopher M. Tegley, Mary C. Walton, Hui-Ling Wang, Ryan P. Wurz, May Xue, Kevin C. Yang, Pragathi Achanta, Michael D. Bartberger, Jude Canon, L. Steven Hollis, John D. McCarter, Christopher Mohr, Karen Rex, Anne Y. Saiki, Tisha San Miguel, Laurie P. Volak, Kevin H. Wang, Douglas A. Whittington, Stephan G. Zech, J. Russell Lipford, Victor J. Cee
Publikováno v:
Journal of Medicinal Chemistry. 63:52-65
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d131821132bab6ea5628a8639f9d9435
https://doi.org/10.1021/acs.jmedchem.9b01180
https://doi.org/10.1021/acs.jmedchem.9b01180
Autor:
Timothy J. Price, Victor J. Cee, Tisha San Miguel, Gerald Steven Falchook, Jonathan Werner, Christopher Mohr, Tao Osgood, James Kuo, Kevin Gaida, Xiaochun Zhu, Karen Rex, John D. McCarter, Brian A. Lanman, H. Henary, Roberto Ortiz, Ramaswamy Govindan, Tara Arvedson, Laurie P. Volak, Wenjun Ouyang, J. Russell Lipford, Tyler Holt, Charles G. Knutson, Neelima Koppada, David S. Hong, Aaron S. Rapaport, Anne Y. Saiki, Bert H. O'Neil, Jude Canon, Ji Rong Sun, Marwan Fakih, Brett E. Houk, Dhanashri Bagal, Keegan Cooke, Jayesh Desai
Publikováno v:
Nature. 575:217-223
KRAS is the most frequently mutated oncogene in cancer and encodes a key signalling protein in tumours1,2. The KRAS(G12C) mutant has a cysteine residue that has been exploited to design covalent inhibitors that have promising preclinical activity3–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4f8225bc18280b2cad72495f7029f3a
https://doi.org/10.1038/s41586-019-1694-1
https://doi.org/10.1038/s41586-019-1694-1
Publikováno v:
2020 Medicinal Chemistry Reviews ISBN: 9781734427400
2020 Medicinal Chemistry Reviews
2020 Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e94e13f6239007ad3e33e8d790678c3
https://doi.org/10.29200/acsmedchemrev-v55.ch10
https://doi.org/10.29200/acsmedchemrev-v55.ch10
Autor:
Hui-Ling Wang, Kristin L. Andrews, Shon K. Booker, Jude Canon, Victor J. Cee, Frank Chavez, Yuping Chen, Heather Eastwood, Nadia Guerrero, Brad Herberich, Dean Hickman, Brian A. Lanman, Jimmy Laszlo, Matthew R. Lee, J. Russell Lipford, Bethany Mattson, Christopher Mohr, Yen Nguyen, Mark H. Norman, Liping H. Pettus, David Powers, Anthony B. Reed, Karen Rex, Christine Sastri, Nuria Tamayo, Paul Wang, Jeffrey T. Winston, Bin Wu, Qiong Wu, Tian Wu, Ryan P. Wurz, Yang Xu, Yihong Zhou, Andrew S. Tasker
Publikováno v:
Journal of Medicinal Chemistry. 62:1523-1540
Pim kinases are a family of constitutively active serine/threonine kinases that are partially redundant and regulate multiple pathways important for cell growth and survival. In human disease, high expression of the three Pim isoforms has been implic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3743f2a152bf3d38a985da1601967443
https://doi.org/10.1021/acs.jmedchem.8b01733
https://doi.org/10.1021/acs.jmedchem.8b01733
Autor:
Christine Sastri, Noelle Javier, Ryan Wurz, J. Russell Lipford, Hannah Dou, Mei-Chu Lo, Victor J. Cee, John McCarter, Ken Dellamaggiore, Dane Mohl
Publikováno v:
Journal of Medicinal Chemistry. 61:453-461
Proteolysis targeting chimeras (PROTACs) are bispecific molecules containing a target protein binder and an ubiquitin ligase binder connected by a linker. By recruiting an ubiquitin ligase to a target protein, PROTACs promote ubiquitination and prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecc44534d76887770e2aaa9542e5fc1
https://doi.org/10.1021/acs.jmedchem.6b01781
https://doi.org/10.1021/acs.jmedchem.6b01781