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Akademický článek

Microbial community organization designates distinct pulmonary exacerbation types and predicts treatment outcome in cystic fibrosis

Autor: Stefanie Widder, Lisa A. Carmody, Kristopher Opron, Linda M. Kalikin, Lindsay J. Caverly, John J. LiPuma

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Polymicrobial infection of the airways is a hallmark of obstructive lung diseases such as cystic fibrosis (CF), non-CF bronchiectasis, and chronic obstructive pulmonary disease. Pulmonary exacerbations (PEx) in these conditions are associate

Externí odkaz: https://doaj.org/article/cf1a281cf36948d7abd6967ae7644c55

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Akademický článek

Clinician Perceptions on Using Decision Tools to Support Prediction-Based Shared Decision Making for Lung Cancer Screening

Autor: Sarah E. Skurla, N. Joseph Leishman, Angela Fagerlin, Renda Soylemez Wiener, Julie Lowery, Tanner J. Caverly

Publikováno v: MDM Policy & Practice, Vol 9 (2024)

Background Considering a patient’s full risk factor profile can promote personalized shared decision making (SDM). One way to accomplish this is through encounter tools that incorporate prediction models, but little is known about clinicians’ per

Externí odkaz: https://doaj.org/article/0d681515d14b4762b06a3626746fb6f7

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Akademický článek

Itaconic acid inhibits nontuberculous mycobacterial growth in pH dependent manner while 4-octyl-itaconic acid enhances THP-1 clearance of nontuberculous mycobacteria in vitro.

Autor: Paul Breen, Madsen Zimbric, Lindsay J Caverly

Publikováno v: PLoS ONE, Vol 19, Iss 5, p e0303516 (2024)

Increasingly prevalent, nontuberculous mycobacteria (NTM) infections affect approximately 20% of people with cystic fibrosis (CF). Previous studies of CF sputum identified lower levels of the host metabolite itaconate in those infected with NTM. Itac

Externí odkaz: https://doaj.org/article/fe8cd32953dd4456ac511d9c245cc110

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Akademický článek

Planning and Reporting Effective Web-Based RAND/UCLA Appropriateness Method Panels: Literature Review and Preliminary Recommendations

Autor: Jordan B Sparks, Mandi L Klamerus, Tanner J Caverly, Sarah E Skurla, Timothy P Hofer, Eve A Kerr, Steven J Bernstein, Laura J Damschroder

Publikováno v: Journal of Medical Internet Research, Vol 24, Iss 8, p e33898 (2022)

BackgroundThe RAND/UCLA Appropriateness Method (RAM), a variant of the Delphi Method, was developed to synthesize existing evidence and elicit the clinical judgement of medical experts on the appropriate treatment of specific clinical presentations.

Externí odkaz: https://doaj.org/article/9e6afc4f3f9b47a18793e630ce314a9c

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Akademický článek

Sputum Metabolites Associated with Nontuberculous Mycobacterial Infection in Cystic Fibrosis

Autor: Paul Breen, Madsen Zimbric, Kristopher Opron, Lindsay J. Caverly

Publikováno v: mSphere, Vol 7, Iss 3 (2022)

ABSTRACT Nontuberculous mycobacterial (NTM) pulmonary infections in people with cystic fibrosis (CF) are associated with significant morbidity and mortality and are increasing in prevalence. Host risk factors for NTM infection in CF are largely unkno

Externí odkaz: https://doaj.org/article/495a9e50a4814caba66e7cbf6925e11f

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Akademický článek

Implementation of a Web-Based Tool for Shared Decision-making in Lung Cancer Screening: Mixed Methods Quality Improvement Evaluation

Autor: Julie Lowery, Angela Fagerlin, Angela R Larkin, Renda S Wiener, Sarah E Skurla, Tanner J Caverly

Publikováno v: JMIR Human Factors, Vol 9, Iss 2, p e32399 (2022)

BackgroundLung cancer risk and life expectancy vary substantially across patients eligible for low-dose computed tomography lung cancer screening (LCS), which has important consequences for optimizing LCS decisions for different patients. To account

Externí odkaz: https://doaj.org/article/1ab69a97f0174366a09f4cc91954c612

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Akademický článek

Comparative Genomics of Mycobacterium avium Complex Reveals Signatures of Environment-Specific Adaptation and Community Acquisition

Autor: Eric C. Keen, JooHee Choi, Meghan A. Wallace, Michelle Azar, Carlos R. Mejia-Chew, Shail B. Mehta, Thomas C. Bailey, Lindsay J. Caverly, Carey-Ann D. Burnham, Gautam Dantas

Publikováno v: mSystems, Vol 6, Iss 5 (2021)

ABSTRACT Nontuberculous mycobacteria, including those in the Mycobacterium avium complex (MAC), constitute an increasingly urgent threat to global public health. Ubiquitous in soil and water worldwide, MAC members cause a diverse array of infections

Externí odkaz: https://doaj.org/article/8033b0c504ae4f659ef2ce119f3789a1

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Akademický článek

The Need for Brevity During Shared Decision Making (SDM) for Cancer Screening: Veterans’ Perspectives on an 'Everyday SDM' Compromise

Autor: Tanner J. Caverly, Sarah E. Skurla, Claire H. Robinson, Brian J. Zikmund-Fisher, Rodney A. Hayward

Publikováno v: MDM Policy & Practice, Vol 6 (2021)

Introduction. Detailed or “full” shared decision making (SDM) about cancer screening is difficult in the primary care setting. Time spent discussing cancer screening is time not spent on other important issues. Given time constraints, brief SDM t

Externí odkaz: https://doaj.org/article/c368ff38ca4949b1b2123f357e8f9b61

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Akademický článek

Cystic fibrosis airway microbiota associated with outcomes of nontuberculous mycobacterial infection

Autor: Lindsay J. Caverly, Madsen Zimbric, Michelle Azar, Kristopher Opron, John J. LiPuma

Publikováno v: ERJ Open Research, Vol 7, Iss 2 (2021)

Rationale Pulmonary infections with nontuberculous mycobacteria (NTM) are increasingly prevalent in people with cystic fibrosis (CF). Clinical outcomes following NTM acquisition are highly variable, ranging from transient self-resolving infection to

Externí odkaz: https://doaj.org/article/8cc33c2b8d8948e2915501b74e5e06d4

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