Zobrazeno 1 - 10 of 155 pro vyhledávání: '"J. Cavalli"'
1
Akademický článek
Non-clinical studies required for new drug development - Part I: early in silico and in vitro studies, new target discovery and validation, proof of principles and robustness of animal studies
Autor: E.L. Andrade, A.F. Bento, J. Cavalli, S.K. Oliveira, C.S. Freitas, R. Marcon, R.C. Schwanke, J.M. Siqueira, J.B. Calixto
Publikováno v: Brazilian Journal of Medical and Biological Research, Vol 49, Iss 11 (2016)
This review presents a historical overview of drug discovery and the non-clinical stages of the drug development process, from initial target identification and validation, through in silico assays and high throughput screening (HTS), identification
Externí odkaz: https://doaj.org/article/2eea8355b8ae439e87a0c77abb4189d9
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2
Akademický článek
Non-clinical studies required for new drug development - Part I: early in silico and in vitro studies, new target discovery and validation, proof of principles and robustness of animal studies
Autor: E.L. Andrade, A.F. Bento, J. Cavalli, S.K. Oliveira, C.S. Freitas, R. Marcon, R.C. Schwanke, J.M. Siqueira, J.B. Calixto
Publikováno v: Brazilian Journal of Medical and Biological Research, Vol 49, Iss 11
This review presents a historical overview of drug discovery and the non-clinical stages of the drug development process, from initial target identification and validation, through in silico assays and high throughput screening (HTS), identification
Externí odkaz: https://doaj.org/article/d02609a4226a4646bd89e53fc6bae170
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3
Akademický článek
Non-clinical studies in the process of new drug development - Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies
Autor: E.L. Andrade, A.F. Bento, J. Cavalli, S.K. Oliveira, R.C. Schwanke, J.M. Siqueira, C.S. Freitas, R. Marcon, J.B. Calixto
Publikováno v: Brazilian Journal of Medical and Biological Research, Vol 49, Iss 12
The process of drug development involves non-clinical and clinical studies. Non-clinical studies are conducted using different protocols including animal studies, which mostly follow the Good Laboratory Practice (GLP) regulations. During the early pr
Externí odkaz: https://doaj.org/article/c597dbfb5d2d458ea47b010426ee9b04
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4
Forage nutritive value of Marandu palisade grass under clipping in a silvopastoral system
Autor: Carlos Guilherme Silveira Pedreira, Dalton Henrique Pereira, J. Cavalli, S. G. Holschuch, Fagner Junior Gomes, Bruno Carneiro e Pedreira
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Canopy adaptation to shade can make forage nutritive value in a silvopastoral system similar or even greater than of open pasture. Our objective was to evaluate the shading effect on nutritive value of Marandu palisade grass [Urochloa brizantha (Hoch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a96ce34c5334dc5ef60d35c94b9c508
https://doi.org/10.1007/s10457-021-00696-6
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5
Frequency of the TP53 R337H variant in sporadic breast cancer and its impact on genomic instability
Autor: Rubens Silveira de Lima, Carolina Prando, Stefanne Bortoletto, Iglenir J. Cavalli, Ana Paula Martins Sebastião, Cicero Urban, Emerson Wander Silva Soares, Heloisa Komechen, Bonald C. Figueiredo, Aline S. Fonseca, Ariana Centa, Carolina Mathias, Enilze M. Ribeiro, Luciane R. Cavalli
Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
The R337H is a TP53 germline pathogenic variant that has been associated with several types of cancers, including breast cancer. Our main objective was to determine the frequency of the R337H variant in sporadic breast cancer patients from Paraná st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b8b0e4b892fee2f545c09e1d6acefb
http://link.springer.com/article/10.1038/s41598-020-73282-y
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8
MiR-150-5p Overexpression in Triple-Negative Breast Cancer Contributes to the In Vitro Aggressiveness of This Breast Cancer Subtype
Autor: Bruna M. Sugita, Yara Rodriguez, Aline S. Fonseca, Emanuelle Nunes Souza, Bhaskar Kallakury, Iglenir J. Cavalli, Enilze M. S. F. Ribeiro, Ritu Aneja, Luciane R. Cavalli
Publikováno v: Cancers; Volume 14; Issue 9; Pages: 2156
MiR-150-5p is frequently deregulated in cancer, with expression and mode of action varying according to the tumor type. Here, we investigated the expression levels and role of miR-150-5p in the aggressive breast cancer subtype triple-negative breast
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bb26fb1f634e017d1f0ae53916902e
https://pubmed.ncbi.nlm.nih.gov/35565284
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10
Akademický článek
Long Non-Coding RNA TUG1 Expression Is Associated with Different Subtypes in Human Breast Cancer
Autor: Daniela F. Gradia, Carolina Mathias, Rodrigo Coutinho, Iglenir J. Cavalli, Enilze M. S. F. Ribeiro, Jaqueline C. de Oliveira
Publikováno v: Non-Coding RNA, Vol 3, Iss 4, p 26 (2017)
Taurine upregulated 1 gene (TUG1) is a long non-coding RNA associated with several types of cancer. Recently, differential expression of TUG1 was found in cancerous breast tissues and associated with breast cancer malignancy features. Although this i
Externí odkaz: https://doaj.org/article/e9f40d05bf0345d580aa9040bf83c0db
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