Zobrazeno 1 - 10
of 201
pro vyhledávání: '"J. Caswell"'
Autor:
Oliver J. Acton, Devon Sheppard, Simone Kunzelmann, Sarah J. Caswell, Andrea Nans, Ailidh J. O. Burgess, Geoff Kelly, Elizabeth R. Morris, Peter B. Rosenthal, Ian A. Taylor
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract SAMHD1 regulates cellular nucleotide homeostasis, controlling dNTP levels by catalysing their hydrolysis into 2’-deoxynucleosides and triphosphate. In differentiated CD4+ macrophage and resting T-cells SAMHD1 activity results in the inhibi
Externí odkaz:
https://doaj.org/article/bfb935999e6b47258373d8f78633ef6d
Autor:
Ming-Han C. Tsai, Sarah J. Caswell, Elizabeth R. Morris, Melanie C. Mann, Simon Pennell, Geoff Kelly, Harriet C. T. Groom, Ian A. Taylor, Kate N. Bishop
Publikováno v:
Retrovirology, Vol 20, Iss 1, Pp 1-18 (2023)
Abstract Background SAMHD1 is a deoxynucleotide triphosphohydrolase that restricts replication of HIV-1 in differentiated leucocytes. HIV-1 is not restricted in cycling cells and it has been proposed that this is due to phosphorylation of SAMHD1 at T
Externí odkaz:
https://doaj.org/article/fcc2447b7cb84ebfa5ff96be2eb62e0d
Publikováno v:
BMJ Open, Vol 13, Iss 9 (2023)
Objectives Most sexual violence (SV) remains undisclosed to healthcare professionals. The aims of this study were to identify where support would be sought after SV and whether routine enquiry about SV was acceptable in a sexual healthcare setting.De
Externí odkaz:
https://doaj.org/article/18c441e757104b4d9d65e5c621c492d5
Autor:
Elizabeth R. Morris, Sarah J. Caswell, Simone Kunzelmann, Laurence H. Arnold, Andrew G. Purkiss, Geoff Kelly, Ian A. Taylor
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
SAMHD1 catalyses the hydrolysis of dNTPs into 2′-deoxynucleosides and triphosphate and is an important regulator of cellular dNTP homeostasis. Here, the authors provide insights into the catalytic mechanism of SAMHD1 by performing kinetic measureme
Externí odkaz:
https://doaj.org/article/33c0aeb332314b7f823450d37d5ea349
Publikováno v:
BMJ Open, Vol 10, Iss 6 (2020)
Introduction Supporting people subjected to sexual violence includes provision of sexual and reproductive healthcare. There is a need to ensure an environment for safe and supported disclosure of sexual violence in these clinical settings. The purpos
Externí odkaz:
https://doaj.org/article/1462b57b86bb40cab5664599a1a0b574
Publikováno v:
International Journal of STD & AIDS. 34:62-66
Sexual violence (SV) has significant impacts on physical, social and psychological wellbeing, with associated mental illness and suicide. Despite no specific guidelines regarding mental health and SV, recommendations suggest all patients should have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6074c1a47fdaf95391441f8216b1f33
https://doi.org/10.1177/09564624221135295
https://doi.org/10.1177/09564624221135295
Autor:
Lucy V. Edwardes, Sarah J. Caswell, Mariacarmela Giurrandino, Xiang Zhai, Andrea Gohlke, Demetrios H. Kostomiris, Hannah K. Pollard, Alexander Pflug, Gregory R. Hamm, Kate V. Jervis, Paul N. Clarkson, Karl Syson
Publikováno v:
Biochemistry. 61:1974-1987
Human lysine methyltransferase 2D (hKMT2D) is an epigenetic writer catalyzing the methylation of histone 3 lysine 4. hKMT2D by itself has little catalytic activity and reaches full activation as part of the WRAD2 complex, additionally comprising bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4381a5f29cee7d23fa10c29cca9377de
https://doi.org/10.1021/acs.biochem.2c00385
https://doi.org/10.1021/acs.biochem.2c00385
Akademický článek
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Akademický článek
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Autor:
Jonathan D C Ross, Gurkiran Birdi, Rachel J Caswell, Oluseyi Ayinde, Karen Lorimer, Helen M Pattison
Publikováno v:
International Journal of STD & AIDS. 33:180-185
Background The scale and extent of sexual violence perpetrated in the United Kingdom is being increasingly acknowledged. Support after the initial disclosure is often sought in NHS sexual health clinics. The purpose of this service evaluation was to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718a208cdff18ea60829013820f27b96
https://doi.org/10.1177/09564624211055962
https://doi.org/10.1177/09564624211055962