Zobrazeno 1 - 10
of 34
pro vyhledávání: '"J. Carlos Villaescusa"'
Autor:
Pierre Sabatier, Christian M. Beusch, Amir A. Saei, Mike Aoun, Noah Moruzzi, Ana Coelho, Niels Leijten, Magnus Nordenskjöld, Patrick Micke, Diana Maltseva, Alexander G. Tonevitsky, Vincent Millischer, J. Carlos Villaescusa, Sandeep Kadekar, Massimiliano Gaetani, Kamilya Altynbekova, Alexander Kel, Per-Olof Berggren, Oscar Simonson, Karl-Henrik Grinnemo, Rikard Holmdahl, Sergey Rodin, Roman A. Zubarev
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
To characterize molecular changes during cell type transitions, the authors develop a method to simultaneously measure protein expression and thermal stability changes. They apply this approach to study differences between human pluripotent stem cell
Externí odkaz:
https://doaj.org/article/ea00b3040ab748c68e25909b2a8c2546
Autor:
Karol Kaiser, Daniel Gyllborg, Jan Procházka, Alena Salašová, Petra Kompaníková, Francisco Lamus Molina, Rocio Laguna-Goya, Tomasz Radaszkiewicz, Jakub Harnoš, Michaela Procházková, David Potěšil, Roger A. Barker, Ángel Gato Casado, Zbyněk Zdráhal, Radislav Sedláček, Ernest Arenas, J. Carlos Villaescusa, Vítězslav Bryja
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
WNTs can signal over long distances but how this arises in the brain is unclear. Here, the authors show that WNT5A is secreted from the choroid plexus of the developing hindbrain (but not the telencephalon) and transported in the CSF with lipoprotein
Externí odkaz:
https://doaj.org/article/b5243ecd5bb74a85a22885abf4c818ed
Autor:
Parvin Kumar, Vincent Millischer, J. Carlos Villaescusa, Ida A. K. Nilsson, Claes-Göran Östenson, Martin Schalling, Urban Ösby, Catharina Lavebratt
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Accumulating evidence suggests that GDF15 is a biomarker for ageing and morbidity of many somatic disorders such as cancer and inflammatory disorders. Recently, elevated serum GDF15 level was proposed as a marker for mood disorder. However,
Externí odkaz:
https://doaj.org/article/afabd871d5f8444d82d2e1fe14837afc
Autor:
D. V. Maltseva, Oscar E. Simonson, J. Carlos Villaescusa, Noah Moruzzi, Roman A. Zubarev, Magnus Nordenskjöld, Alexander G. Tonevitsky, Amir Ata Saei, Massimiliano Gaetani, Mike Aoun, Niels Leijten, Kamilya Altynbekova, Vincent Millischer, Rikard Holmdahl, Per Olof Berggren, Pierre Sabatier, Karl-Henrik Grinnemo, Alexander E. Kel, Ana Coelho, Sandeep Kadekar, Sergey Rodin, Christian M. Beusch, Patrick Micke
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Detailed characterization of cell type transitions is essential for cell biology in general and particularly for the development of stem cell-based therapies in regenerative medicine. To systematically study such transitions, we introduce a method th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53699eab999c9c3a454543eb2a71c17
http://europepmc.org/articles/PMC8590018
http://europepmc.org/articles/PMC8590018
Autor:
Lola Torz, Kristoffer Niss, Sofia Lundh, Jens C. Rekling, Carlos Damian Quintana, Signe Emilie Dannulat Frazier, Aaron J. Mercer, Anda Cornea, Charlotte Vinther Bertelsen, Marina Kjærgaard Gerstenberg, Ann Maria Kruse Hansen, Mette Guldbrandt, Jens Lykkesfeldt, Linu Mary John, J. Carlos Villaescusa, Natalia Petersen
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 6; Pages: 3260
Torz, L, Niss, K, Lundh, S, Rekling, J C, Quintana, C D, Frazier, S E D, Mercer, A J, Cornea, A, Bertelsen, C V, Gerstenberg, M K, Hansen, A M K, Guldbrandt, M, Lykkesfeldt, J, John, L M, Villaescusa, J C & Petersen, N 2022, ' NPFF Decreases Activity of Human Arcuate NPY Neurons : A Study in Embryonic-Stem-Cell-Derived Model ', International Journal of Molecular Sciences, vol. 23, no. 6, 3260 . https://doi.org/10.3390/ijms23063260
Torz, L, Niss, K, Lundh, S, Rekling, J C, Quintana, C D, Frazier, S E D, Mercer, A J, Cornea, A, Bertelsen, C V, Gerstenberg, M K, Hansen, A M K, Guldbrandt, M, Lykkesfeldt, J, John, L M, Villaescusa, J C & Petersen, N 2022, ' NPFF Decreases Activity of Human Arcuate NPY Neurons : A Study in Embryonic-Stem-Cell-Derived Model ', International Journal of Molecular Sciences, vol. 23, no. 6, 3260 . https://doi.org/10.3390/ijms23063260
Restoring the control of food intake is the key to obesity management and prevention. The arcuate nucleus (ARC) of the hypothalamus is extensively being studied as a potential anti-obesity target. Animal studies showed that neuropeptide FF (NPFF) red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb1075b5312e468a62bab39485ceb3a
https://doi.org/10.3390/ijms23063260
https://doi.org/10.3390/ijms23063260
Autor:
Joëlle Rȕegg, J. Carlos Villaescusa, Philippe A. Melas, Liu L. Yang, Tomas J. Ekström, Maria Rosaria Galanti, Paschalis Efstathopoulos, Yvonne Forsell, Catharina Lavebratt, Filip Andersson
Publikováno v:
Translational Psychiatry, Vol 8, Iss 1, Pp 1-8 (2018)
The disruption of key epigenetic processes during critical periods of brain development can increase an individual’s vulnerability to psychopathology later in life. For instance, DNA methylation in the glucocorticoid receptor gene (NR3C1) in adulth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb69a08ba2d69127f6902cddcd8fb20
http://link.springer.com/article/10.1038/s41398-018-0169-8
http://link.springer.com/article/10.1038/s41398-018-0169-8
Autor:
Claes-Göran Östenson, Parvin Kumar, Vincent Millischer, Martin Schalling, Ida A. K. Nilsson, J. Carlos Villaescusa, Catharina Lavebratt, Urban Ösby
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports
Scientific Reports
Accumulating evidence suggests that GDF15 is a biomarker for ageing and morbidity of many somatic disorders such as cancer and inflammatory disorders. Recently, elevated serum GDF15 level was proposed as a marker for mood disorder. However, psychosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8525e6683c9d30e42af4026d0df72751
https://doaj.org/article/afabd871d5f8444d82d2e1fe14837afc
https://doaj.org/article/afabd871d5f8444d82d2e1fe14837afc
Autor:
Martin Schalling, J. Carlos Villaescusa, Oliver Brüstle, Ya Bin Wei, Eric Olsson, Parvin Kumar, Catharina Lavebratt, Vincent Millischer, Urban Ösby, Paschalis Efstathopoulos
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-1 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-1 (2019)
Mitochondrial pathology has been implicated in the pathogenesis of psychotic disorders. A few studies have proposed reduced leukocyte mitochondrial DNA (mtDNA) copy number in schizophrenia and bipolar disorder type I, compared to healthy controls. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc28d6fe1c400b6c6cd2c0bd4e2bfeb
http://europepmc.org/articles/PMC6831574
http://europepmc.org/articles/PMC6831574
Autor:
Michelle K. Skime, John D. Port, Jennifer R. Geske, Mark A. Frye, David J. Bond, Doo Sup Choi, Lena Backlund, Vincent Millischer, Susan L. McElroy, Joanna M. Biernacka, J. Carlos Villaescusa, Yun Fang Jia, Marin Veldic, Ada Man Choi Ho, Catharina Lavebratt, Martin Schalling
Publikováno v:
Translational Psychiatry, Vol 9, Iss 1, Pp 1-10 (2019)
Translational Psychiatry
Translational Psychiatry
Glutamatergic dysregulation is implicated in the neurobiology of mood disorders. This study investigated the relationship between the anterior cingulate cortex (AC) glutamate, as measured by proton magnetic resonance spectroscopy (1H-MRS), and single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b6d0f397512a6072f4abf1467118dc
https://doi.org/10.1038/s41398-019-0483-9
https://doi.org/10.1038/s41398-019-0483-9
Autor:
Zbyněk Zdráhal, J. Carlos Villaescusa, Rocio Laguna-Goya, Karol Kaiser, Francisco Lamus Molina, Vítězslav Bryja, Radislav Sedlacek, Daniel Gyllborg, Petra Kompanikova, Ernest Arenas, Ángel Gato Casado, Jakub Harnoš, Alena Salašová, Tomasz Witold Radaszkiewicz, David Potěšil, Michaela Prochazkova, Roger A. Barker, Jan Prochazka
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Kaiser, K, Gyllborg, D, Procházka, J, Salašová, A, Kompaníková, P, Molina, F L, Laguna-Goya, R, Radaszkiewicz, T, Harnoš, J, Procházková, M, Potěšil, D, Barker, R A, Casado, Á G, Zdráhal, Z, Sedláček, R, Arenas, E, Villaescusa, J C & Bryja, V 2019, ' WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis ', Nature Communications, vol. 10, no. 1, 1498 . https://doi.org/10.1038/s41467-019-09298-4
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Kaiser, K, Gyllborg, D, Procházka, J, Salašová, A, Kompaníková, P, Molina, F L, Laguna-Goya, R, Radaszkiewicz, T, Harnoš, J, Procházková, M, Potěšil, D, Barker, R A, Casado, Á G, Zdráhal, Z, Sedláček, R, Arenas, E, Villaescusa, J C & Bryja, V 2019, ' WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis ', Nature Communications, vol. 10, no. 1, 1498 . https://doi.org/10.1038/s41467-019-09298-4
WNTs are lipid-modified proteins that control multiple functions in development and disease via short- and long-range signaling. However, it is unclear how these hydrophobic molecules spread over long distances in the mammalian brain. Here we show th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8a03c1fdd2276e90d12c312ffda8f8
