Výsledky vyhledávání - "J. Cameron Finley"

Epicatechin regulation of mitochondrial structure and function is opioid receptor dependent

Autor: Hemal H. Patel, J. Cameron Finley, David M. Roth, Piyush M. Patel, Sameh S. Ali, Sarah E Kellerhals, Mathivadhani Panneerselvam, Michael Y. Migita, Brian P. Head

Publikováno v: Molecular Nutrition & Food Research. 57:1007-1014

Scope The flavanol (–)-epicatechin (Epi), a component of cacao, has cardiac protective benefits in humans. Our previous study demonstrated Epi has δ-opioid receptor (DOR) binding activity and promotes cardiac protection. Here we examined the effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664cc5f6817d2fca4df212e395921636
https://doi.org/10.1002/mnfr.201300026

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Thy-1 interaction with Fas in lipid rafts regulates fibroblast apoptosis and lung injury resolution

Autor: Simon S. Wong, Jeeyeon Kim, J. Cameron Finley, John E. Bradley, Xiaoqiu Liu, Hemal H. Patel, Brian P. Head, Carmen A. Taype, Tzu-Pin Shentu, Emma J. Mah, Celia R. Espinoza, James S. Hagood

Publikováno v: Laboratory investigation; a journal of technical methods and pathology

Thy-1-negative lung fibroblasts are resistant to apoptosis. The mechanisms governing this process and its relevance to fibrotic remodeling remain poorly understood. By using either sorted or transfected lung fibroblasts, we found that Thy-1 expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c1298cf9a60b548447b79c9e28582e
https://pubmed.ncbi.nlm.nih.gov/28165468

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Cardioprotective trafficking of caveolin to mitochondria is Gi-protein dependent

Autor: Hemal H. Patel, J. Cameron Finley, Ingrid R. Niesman, David M. Roth, Jiawan Wang, Jan M. Schilling, Piyush M. Patel, John P. Headrick, Evan Kwan, Yun Yue, Brian P. Head

Publikováno v: Anesthesiology, vol 121, iss 3

Background: Caveolae are a nexus for protective signaling. Trafficking of caveolin to mitochondria is essential for adaptation to cellular stress though the trafficking mechanisms remain unknown. The authors hypothesized that G protein–coupled rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6946818e96bfe069bdc3c687ed65514e
https://europepmc.org/articles/PMC4219636/

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Caveolin isoform switching as a molecular, structural, and metabolic regulator of microglia

Autor: Hemal H. Patel, J. Cameron Finley, Nathan Zemke, Brian P. Head, Ingrid R. Niesman, David M. Roth, Karen Levy, Anna M. H. Grove, Kristofer J. Haushalter, Piyush M. Patel, Rosalie Schnoor, Heidi N. Fridolfsson

Microglia are ramified cells that serve as central nervous system (CNS) guardians, capable of proliferation, migration, and generation of inflammatory cytokines. In non-pathological states, these cells exhibit ramified morphology with processes inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ba72e12a4f3a07c9206a02998f7229
https://europepmc.org/articles/PMC3791173/

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A kinase interacting protein (AKIP1) is a key regulator of cardiac stress

Publikováno v: Proceedings of the National Academy of Sciences. 110

cAMP-dependent protein kinase (PKA) regulates a myriad of functions in the heart, including cardiac contractility, myocardial metabolism,and gene expression. However, a molecular integrator of the PKA response in the heart is unknown. Here, we show t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968adb88740c94326fd807feb008efce
https://doi.org/10.1073/pnas.1221670110

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Mitochondria-localized caveolin in adaptation to cellular stress and injury

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(11)

We show here that the apposition of plasma membrane caveolae and mitochondria (first noted in electron micrographs >50 yr ago) and caveolae-mitochondria interaction regulates adaptation to cellular stress by modulating the structure and function of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947dfdffeba862fdd444117d71ddd14f
https://pubmed.ncbi.nlm.nih.gov/22859372

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Copper influx transporter 1 is required for FGF, PDGF and EGF-induced MAPK signaling

Autor: Sameh S. Ali, Stephen B. Howell, Hemal H. Patel, Cheng-Yu Tsai, J. Cameron Finley

Copper transporter 1 (CTR1) is the major copper (Cu) influx transporter in mammalian cells. We report here that CTR1 is required for the activation of signaling to the MAPK pathway by the ligands of three major receptor tyrosine kinases (RTK) includi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d23cd2dd115e647957f29912acf0ea4
https://europepmc.org/articles/PMC3464187/

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Effect of low‐dose epicatechin on mitochondrial function and membrane fluidity

Autor: J. Cameron Finley, Mathivadhani Panneerselvam, Sameh S. Ali, Hemal H. Patel, David M. Roth

Publikováno v: The FASEB Journal. 26

Epicatechin, a dark chocolate flavonol/antioxidant, is linked to cardiovascular cytoprotection. Myocardial infarct size was decreased in epicatechin-treated mice compared to controls, and this effe...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a36d5f47e26e0d44b142c310c9d351d
https://doi.org/10.1096/fasebj.26.1_supplement.852.1

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