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Supplementary Figure Legends from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

Legends for Supplementary Figures 1 - 7.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2ea8b1988f522a97b4476bc1bfb489
https://doi.org/10.1158/0008-5472.22409537.v1

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Supplementary Figures from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

Supplementary Figure 1 contains a Western blot showing the amount of estrogen receptor remaining after treatment of MCF-7 cells with AZD9496, fulvestrant and estradiol alongside GAPDH protein levels as an internal gel loading control; Supplementary F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c5919450d0037769dc8885c171e5d8
https://doi.org/10.1158/0008-5472.22409534.v1

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Data from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

Fulvestrant is an estrogen receptor (ER) antagonist administered to breast cancer patients by monthly intramuscular injection. Given its present limitations of dosing and route of administration, a more flexible orally available compound has been sou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121cf8596ca6963e592f8c1559e47fd8
https://doi.org/10.1158/0008-5472.c.6507809.v1

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Supplementary Tables and Legends from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

Supplementary Table 1 contains crystallographic data collection and refinements statistics for AZD9496 binding to the human estrogen receptor α ligand binding domain, Supplementary Table 2 shows the rate constants for association, dissociation and e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc4d27d54650a74388b4e3bbd209d6f
https://doi.org/10.1158/0008-5472.22409528

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Supplementary Methods from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

Methods are given for: the use of SILAC assays to measure the rate of estrogen receptor α peptide degradation over time, the measurement of compound binding affinity of estrogen receptor α ligand binding domain using BIAcore, immunoblotting of estr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500fb6b45ef15b3a4c16d2efaec374bf
https://doi.org/10.1158/0008-5472.22409531

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Akademický článek

Simultaneous Magmatic and Hydrothermal Regimes in Alta–Little Cottonwood Stocks, Utah, USA, Recorded Using Multiphase U-Pb Petrochronology

Autor: Michael A. Stearns, John M. Bartley, John R. Bowman, Clayton W. Forster, Carl J. Beno, Daniel D. Riddle, Samuel J. Callis, Nicholas D. Udy

Publikováno v: Geosciences, Vol 10, Iss 4, p 129 (2020)

Magmatic and hydrothermal systems are intimately linked, significantly overlapping through time but persisting in different parts of a system. New preliminary U-Pb and trace element petrochronology from zircon and titanite demonstrate the protracted

Externí odkaz: https://doaj.org/article/2e3c6ed3dda345108491e2d2f0dd4184

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Akademický článek

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[Le génie génétique appliqué à la santé et à la production animales]

Autor: J J, Callis

Publikováno v: Revue scientifique et technique (International Office of Epizootics). 3(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ab34bbaed53163ac2cc7b7db3f4035d1
https://pubmed.ncbi.nlm.nih.gov/32988011

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Simultaneous Magmatic and Hydrothermal Regimes in Alta–Little Cottonwood Stocks, Utah, USA, Recorded Using Multiphase U-Pb Petrochronology

Autor: Daniel D. Riddle, Nicholas D. Udy, John M. Bartley, Samuel J. Callis, John R. Bowman, Michael A. Stearns, Clayton Forster, Carl J. Beno

Publikováno v: Geosciences
Volume 10
Issue 4
Geosciences, Vol 10, Iss 129, p 129 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949b9c867d8a7a40f601597750de7ec5

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