Výsledky vyhledávání - "J. C. Yalowich"

ChemInform Abstract: Structure-Activity Relationships of Mammalian Topoisomerase II Inhibitors Related to Ellipticine

Autor: J. C. Yalowich, J. D. Laskin, E. J. Lavoie, R. L. Schenkman

Publikováno v: ChemInform. 23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ba0b90a818a858d47cc97a9b7eb5f8c
https://doi.org/10.1002/chin.199247194

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Nitric oxide prevents oxidative damage produced by tert-butyl hydroperoxide in erythroleukemia cells via nitrosylation of heme and non-heme iron. Electron paramagnetic resonance evidence

Autor: N V, Gorbunov, J C, Yalowich, A, Gaddam, P, Thampatty, V B, Ritov, E R, Kisin, N M, Elsayed, V E, Kagan

Publikováno v: The Journal of biological chemistry. 272(19)

We studied protective effects of NO against tert-butylhydroperoxide (t-BuOOH)-induced oxidations in a subline of human erythroleukemia K562 cells with different intracellular hemoglobin (Hb) concentrations. t-BuOOH-induced formation of oxoferryl-Hb-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f4639ffc8f4312f81ab5de67e3f0a7ed
https://pubmed.ncbi.nlm.nih.gov/9139677

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Interactions of phenoxyl radical of antitumor drug, etoposide, with reductants in solution and in cell and nuclear homogenates: electron spin resonance and high-performance liquid chromatography

Autor: T G, Gantchev, J E, van Lier, D A, Stoyanovsky, J C, Yalowich, V E, Kagan

Publikováno v: Methods in enzymology. 234

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2068b4b2272103c4dabb8c7a83e8ad8
https://pubmed.ncbi.nlm.nih.gov/7808339

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Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro

Autor: I D Goldman, D. W. Fry, J. C. Yalowich

Publikováno v: Journal of Biological Chemistry. 257:1890-1896

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e405f01d1948599148e07b0fc75851f
https://doi.org/10.1016/s0021-9258(19)68121-4

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Characteristics of the accumulation of methotrexate polyglutamate derivatives in Ehrlich ascites tumor cells and isolated rat hepatocytes

Autor: D W, Fry, D A, Gewirtz, J C, Yalowich, I D, Goldman

Publikováno v: Advances in experimental medicine and biology. 163

The intracellular synthesis and retention of polygammaglutamyl derivatives of methotrexate and their interactions with H2 folate reductase was evaluated in the Ehrlich ascites tumor cell and the isolated rat hepatocyte. Methotrexate polyglutamates we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75c3102620eb86ff397c78f5451c6438
https://pubmed.ncbi.nlm.nih.gov/6193686

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Analysis of the inhibitory effects of VP-16-213 (etoposide) and podophyllotoxin on thymidine transport and metabolism in Ehrlich ascites tumor cells in vitro

Autor: J C, Yalowich, I D, Goldman

Publikováno v: Cancer research. 44(3)

These studies explore the effects of an epipodophyllotoxin on the membrane transport and metabolism of thymidine in Ehrlich ascites tumor cells. Uptake of 3H after exposure of cells to [3H]-thymidine is characterized by a rapid initial velocity that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d596f3daa5a03c4abecb51d9166f3ce2
https://pubmed.ncbi.nlm.nih.gov/6692420

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Potentiation of etoposide-induced DNA damage by calcium antagonists in L1210 cells in vitro

Autor: J C, Yalowich, W E, Ross

Publikováno v: Cancer research. 44(8)

Verapamil and a number of other Ca2+ antagonists were found to potentiate DNA damage induced by 4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidene-beta-D-glucop yra noside (VP-16) in L1210 cells in vitro. The potentiating effect of verapamil on DNA si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::74797805bc9ee05d90653796f2f3dd7b
https://pubmed.ncbi.nlm.nih.gov/6744270

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Effects of microtubule inhibitors on etoposide accumulation and DNA damage in human K562 cells in vitro

Autor: J C, Yalowich

Publikováno v: Cancer research. 47(4)

The effects of microtubule inhibitors on cellular accumulation of 4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidine-beta-D-glu copyranoside) (VP-16) and subsequent epipodophyllotoxin-induced DNA single-strand breaks were investigated in human leukemi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ce0e32d82636732a65941e245b1080cb
https://pubmed.ncbi.nlm.nih.gov/2879622

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Verapamil-induced augmentation of etoposide accumulation in L1210 cells in vitro

Autor: J C, Yalowich, W E, Ross

Publikováno v: Cancer research. 45(4)

The effects of the calcium antagonist verapamil on the intracellular disposition of 4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidene-beta-D-glucopyra noside) (etoposide) (VP-16) as well as on subsequent DNA damage and cytotoxicity were studied in L1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e997bd5c7740aca00e9e237ea917ba6f
https://pubmed.ncbi.nlm.nih.gov/3978633

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