Výsledky vyhledávání - "J. C. Tigner"

An oral carcinogenicity and toxicity study of senna (Tinnevelly senna fruits) in the rat

Autor: S. McPherson, J. C. Tigner, P. Dettmar, R. Gregson, U. Mengs, J. M. Mitchell, J. Zijlstra

Publikováno v: Archives of Toxicology. 80:34-44

Senna (Tinnevelly senna fruits), a known laxative derived from plants, was administered by gavage to Sprague-Dawley (Crl:CD (SD) BR) rats once daily at dose levels of 0, 25, 100 and 300 mg/kg/day for up to 104 consecutive weeks. Based upon clinical s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc25823fc8dbfa99cb44a37ffd4a972
https://doi.org/10.1007/s00204-005-0021-9

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A 13-week oral toxicity study of senna in the rat with an 8-week recovery period

Autor: S. McPherson, J. M. Mitchell, R. Gregson, J. C. Tigner, U. Mengs

Publikováno v: Archives of toxicology. 78(5)

Senna was administered by gavage to Sprague Dawley rats once daily at dose levels of 0, 100, 300, 750 or 1500 mg/kg for up to 13 consecutive weeks followed by an 8-week recovery period for selected animals. Dose- and treatment-related clinical signs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071d18579c4f282a022140be1b8f83bc
https://pubmed.ncbi.nlm.nih.gov/14997282

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