Výsledky vyhledávání - "J. C. Teulade"

Using the Sonogashira Reaction for Preparing a New Fragment Library based on the 3-alkynylimidazo[1,2-alpha] pyridine Scaffold

Autor: Pierre Verhaeghe, Caroline Castera-Ducros, J. C. Teulade, Melanie Piednoel, Vincent Remusat, Patrice Vanelle, Pascal Rathelot, Hussein El-Kashef

Publikováno v: Letters in Organic Chemistry
Letters in Organic Chemistry, Bentham Science Publishers, 2016, 13 (7), pp.519-525. ⟨10.2174/1570178613666160919124456⟩
Letters in Organic Chemistry, 2016, 13 (7), pp.519-525. ⟨10.2174/1570178613666160919124456⟩

International audience; Background:The imidazo[1,2-alpha] pyridine ring has been widely studied by medicinal chemists and displays great pharmaceutical potential. Methods: In a view to prepare a library of new molecules including an imidazo[1,2-alpha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e75b64d6b888be1ac4140ca49e6979d
https://hal.archives-ouvertes.fr/hal-01460673

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Design, synthesis, and biological activities of conformationally restricted analogs of primaquine with a 1,10-phenanthroline framework

Autor: Ange-Désiré Yapi, Alexis Valentin, Yves Blache, Jean-Michel Chezal, Nicolas Desbois, Séverine Chevalley, J. C. Teulade, Kimny Tan, Cheikh Sall

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:4666-4669

A series of primaquine analogs was prepared, according to a conformationally restricted conformation of primaquine. In vitro antiplasmodial activities were evaluated and showed that all compounds were active on different strains of Plasmodium falcipa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7563a6312e492198f7e69666aea6c0
https://doi.org/10.1016/j.bmcl.2008.07.013

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An efficient route to a 5,6-dihydropyrano[3,4-b]pyridin-8-one core in two steps from enaminolactones

Autor: José Camacho, Jean-Michel Chezal, Nicolas Desbois, Yves Blache, Cheikh Sall, J. C. Teulade, Sandrine Paquelet

Publikováno v: Tetrahedron Letters. 49:1301-1304

A convenient two step conversion of heterocyclic enaminolactones to heterocyclic fused 2-pyran-1-ones is reported. The use of this method can be applied to a wide variety of aromatic and heteroaromatic amines to give potentially biologically active c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9e4251f8064161aeb7cdc195e76afdf
https://doi.org/10.1016/j.tetlet.2007.12.106

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In vitro biological effects of two anti-diabetic medicinal plants used in Benin as folk medicine

Autor: Christiane Forestier, Fifa Theomaine Diane Bothon, J. C. Teulade, Eric Debiton, Félicien Avlessi, Dominique K. C. Sohounhloue

Publikováno v: BMC Complementary and Alternative Medicine
BMC Complementary and Alternative Medicine, BioMed Central, 2013, 13 (1), pp.51. ⟨10.1186/1472-6882-13-51⟩
BMC Complementary and Alternative Medicine, 2013, 13 (1), pp.51. ⟨10.1186/1472-6882-13-51⟩

Background Extracts from Polygonum senegalensis (Polygonaceae) and Pseudocedrela kotschyi (Meliaceae) are two important traditionally used medicinal plants in rural Benin to treat many diseases and notably type 2 diabetes. The aim of the study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa32809b7c163443525dc70aa440676c
https://www.hal.inserm.fr/inserm-00798331/file/1472-6882-13-51.pdf

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Imidazonaphthyridine systems (part 2): Functionalization of the phenyl ring linked to the pyridine pharmacophore and its replacement by a pyridinone ring produces intriguing differences in cytocidal activity

Autor: Nicolas Masurier, Emmanuel Moreau, Jacques Lacroix, Anthony Ollivier, J. C. Teulade, Marie-Joseph Galmier, René C.-Gaudreault, Olivier Chavignon, Mounir Andaloussi, Damien Canitrot, Alicia Jacquemet, Jean-Michel Chezal, Daté Tétégan, Antoine Bussière, Eric Debiton

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2012, 52, pp.137-150. ⟨10.1016/j.ejmech.2012.03.011⟩
European Journal of Medicinal Chemistry, 2012, 52, pp.137-150. ⟨10.1016/j.ejmech.2012.03.011⟩

We recently discovered that five- and pseudo-five-fused-ring derivatives in an imidazonaphthyridine series were promising hit compounds for the development of new DNA-intercalators. In this study, novel (dihydro)imidazo[1,6] and [1,7]naphthyridi(no)n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0621e5d652565fbbc543ce2c5f82a37
https://hal.archives-ouvertes.fr/hal-01677549

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Heterocyclizations in the pyrido[2,3-b]pyrazine series

Autor: Gérard Dauphin, A. Gueiffier, H. Viols, Yves Blache, J. P. Chapat, J. C. Milhavet, Olivier Chavignon, J. C. Teulade

Publikováno v: Journal of Heterocyclic Chemistry. 31:161-166

In this paper, we report the results of heterocyclizations in the pyrido[2,3-b]pyrazine series to give the pyrido[2,3-e] or [3,2-e]pyrrolo[1,2-a]pyrazine. The Clauson-Kaas reaction on 2,3-diaminopyridine is investigated; regioselectivity on the 3-ami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2853afec59466393a8edc1e389f6641
https://doi.org/10.1002/jhet.5570310127

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Inhibitory effects on platelet aggregation and cyclic AMP phosphodiesterase of azaindolizine-type compounds

Autor: Jean-Luc Stigliani, Gérard Grassy, Jacques Szefner, Jean-Pierre Chapat, Yves Adam, J. C. Teulade, A. Gueiffier

Publikováno v: Chemometrics and Intelligent Laboratory Systems. 20:71-84

Grassy, G., Stigliani, J.-L., Szefner, J., Gueiffier, A., Teulade, J.-C., Chapat, J.-P. and Adam, Y., 1993. Inhibitory effects on platelet aggregation and cyclic AMP phosphodiesterase of azaindolizine-type compounds. Structure-activity relationships

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11e2252494f27a8e84a461a2cecc74b5
https://doi.org/10.1016/0169-7439(93)80022-a

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Short and efficient access to imidazo[1,2-a]pyrrolo[3,2-c]pyridine derivatives

Autor: Johan Neyts, J. Metin, J. C. Teulade, Jean-Michel Chezal, Vincent Gaumet, Olivier Chavignon, Jan Paeshuyse, Claire Lartigue, Fernand Leal, Abbass Taleb, Emmanuel Moreau, Alain Gueiffier

Publikováno v: Tetrahedron Letters
Tetrahedron Letters, 2010, 51 (47), pp.6082-6085. ⟨10.1016/j.tetlet.2010.09.056⟩
Tetrahedron Letters, Elsevier, 2010, 51 (47), pp.6082-6085. ⟨10.1016/j.tetlet.2010.09.056⟩

Access to N-protected or N-free imidazo[1,2- a ]pyrrolo[3,2- c ]pyridine derivatives as potential antiviral compounds was achieved in good yields from N-protected 7-amino-8-halo-2-methylimidazo[1,2- a ]pyridines by catalytic coupling of terminal acet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566d2f33f43459332d0f3b2a02cbf354
https://hal.science/hal-01677637

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