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An Assessment of the Mechanistic Differences Between Two Integrin α4β1Inhibitors, the Monoclonal Antibody TA-2 and the Small Molecule BIO5192, in Rat Experimental Autoimmune Encephalomyelitis

Autor: Roy R. Lobb, Mark Cornebise, Russell C. Petter, C. Nickerson-Nutter, K. Wortham, Doreen Lepage, R. B. Pepinsky, Wen-Cherng Lee, Steve Adams, L. L. Chen, Daniel Scott, J. C. Spell, Brian M. Dolinski, Alan Gill, W. Yang, Keith Giza, Stuart J. Perper, Eric T. Whalley, Diane R Leone

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 305:1150-1162

Integrin alpha 4 beta 1 plays an important role in inflammatory processes by regulating the migration of lymphocytes into inflamed tissues. Here we evaluated the biochemical, pharmacological, and pharmacodynamic properties and efficacy in experimenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08a2c9025a531d25a49df899c5a776c
https://doi.org/10.1124/jpet.102.047332

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Supercritical fluid extraction and negative ion electrospray liquid chromatography tandem mass spectrometry analysis of phenobarbital, butalbital, pentobarbital and thiopental in human serum

Autor: J C, Spell, K, Srinivasan, J T, Stewart, M G, Bartlett

Publikováno v: Rapid communications in mass spectrometry : RCM. 12(13)

Four commonly used barbiturates (phenobarbital, butalbital, pentobarbital and thiopental) were analyzed in human serum using supercritical fluid extraction (SFE) and negative ionization LC/ESI-MS/MS. Barbital was used as the internal standard. Carbon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d40401cb6b861c4e8112baafcd220988
https://pubmed.ncbi.nlm.nih.gov/9684381

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