Výsledky vyhledávání - "J. C. Sowden"

Akademický článek

Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors

Autor: R. A. Pearson, A. Gonzalez-Cordero, E. L. West, J. R. Ribeiro, N. Aghaizu, D. Goh, R. D. Sampson, A. Georgiadis, P. V. Waldron, Y. Duran, A. Naeem, M. Kloc, E. Cristante, K. Kruczek, K. Warre-Cornish, J. C. Sowden, A. J. Smith, R. R. Ali

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)

Transplantation of healthy photoreceptor cells has been shown to rescue blindness. Here, the authors show that rather than donor cells integrating into the host retina, the predominant mechanism underlying this rescue involves exchange of cytoplasmic

Externí odkaz: https://doaj.org/article/b15e33f7b89f4b918a0a570c180b0b86

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Akademický článek

Manipulation of the Recipient Retinal Environment by Ectopic Expression of Neurotrophic Growth Factors Can Improve Transplanted Photoreceptor Integration and Survival

Autor: E. L. West, R. A. Pearson, Y. Duran, A. Gonzalez-Cordero, R. E. Maclaren, A. J. Smith, J. C. Sowden, R. R. Ali

Publikováno v: Cell Transplantation, Vol 21 (2012)

Degeneration of the neural retina is the leading cause of untreatable blindness in the developed world. Stem cell replacement therapy offers a novel strategy for retinal repair. Postmitotic photoreceptor precursors derived from the early postnatal (P

Externí odkaz: https://doaj.org/article/9edac738641e4c0da01e9a8e0eeffbd4

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Akademický článek

Targeted Disruption of Outer Limiting Membrane Junctional Proteins (Crb1 and ZO-1) Increases Integration of Transplanted Photoreceptor Precursors into the Adult Wild-Type and Degenerating Retina

Autor: R. A. Pearson, A. C. Barber, E. L. West, R. E. Maclaren, Y. Duran, J. W. Bainbridge, J. C. Sowden, R. R. Ali

Publikováno v: Cell Transplantation, Vol 19 (2010)

Diseases culminating in photoreceptor loss are a major cause of untreatable blindness. Transplantation of rod photoreceptors is feasible, provided donor cells are at an appropriate stage of development when transplanted. Nevertheless, the proportion

Externí odkaz: https://doaj.org/article/047abcd08ebc43c88c765a4c8e1c2952

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Expression of Drosophila omb-related T-box genes in the developing human and mouse neural retina

Autor: J C, Sowden, J K, Holt, M, Meins, H K, Smith, S S, Bhattacharya

Publikováno v: Investigative ophthalmologyvisual science. 42(13)

To examine the role of Drosophila optomotor blind (omb)-related T-box genes in development of human and mouse retina.Mouse Tbx2, Tbx3, and Tbx5 and human TBX2 cDNAs were isolated from retinal cDNA libraries by hybridization to the Drosophila omb gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::42deb43e73fcae12174383da2411ab84
https://pubmed.ncbi.nlm.nih.gov/11726608

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