Výsledky vyhledávání - "J. C. STREET"

A 1H/15N n.m.r. study of nitrogen metabolism in cultured mammalian cells

Autor: P S H Braddock, A M Delort, Kevin M. Brindle, J C Street

Publikováno v: Biochemical Journal. 291:485-492

1. Heteronuclear 1H/15N n.m.r. experiments are described in which 15N labelling of cellular metabolites is detected via their proton resonances. 2. These n.m.r. experiments have been used to monitor label redistribution amongst extracellular metaboli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297344b83c2e59b66f1f24ecdce76cb2
https://doi.org/10.1042/bj2910485

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Quantitation of metabolic and radiobiological effects of 6-aminonicotinamide in RIF-1 tumor cells in vitro

Autor: J C, Street, A A, Alfieri, J A, Koutcher

Publikováno v: Cancer research. 57(18)

6-Aminonicotinamide (6AN) can be metabolized to 6-amino-NAD(P+), a competitive inhibitor of NAD(P+)-requiring processes, especially the pentose phosphate pathway (PPP) enzyme, 6-phosphogluconate dehydrogenase. The effect of 6AN on the flux of 1 and 6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::40318e06c0dfa155f4b2a1ac3d82becb
https://pubmed.ncbi.nlm.nih.gov/9307279

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In vivo detection by 31P NMR of pentose phosphate pathway block secondary to biochemical modulation

Autor: U, Mahmood, J C, Street, C, Matei, D, Ballon, D S, Martin, J A, Koutcher

Publikováno v: NMR in biomedicine. 9(3)

The chemotherapeutic regimen of N-(phosphonacetyl)-L-aspartate (PALA) followed 17 h later by 6-methylmercaptopurine riboside (MMPR) and 6-aminonicotanamide (6AN) has been shown to be a potent sensitizer of anti-neoplastic therapy. We undertook this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::177fba8ec7ea1670c1e60b1f0a20ba49
https://pubmed.ncbi.nlm.nih.gov/8892397

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Study of coumarin metabolism by Chinese hamster lung fibroblasts expressing a human cytochrome P450 using H-nmr

Autor: J C, Street, J S, Lee, M A, Jarema

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 26(4)

1. Human cytochrome P450 2A6 is expressed in Chinese hamster lung fibroblasts. The isozyme hydroxylates coumarin at the 7-position. 2. Metabolism of coumarin in these lung fibroblasts was monitored using 1H-nmr. Media samples were taken from cells gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::513ccaf4d0fe0c016312d5483ac76521
https://pubmed.ncbi.nlm.nih.gov/9173685

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Assessing the magnitude of antiemetic benefit with the addition of the NK1 receptor antagonist (NK1) aprepitant for all platinum agents: Analysis of 1,872 patients (pts) in prospective randomized clinical phase III trials (RCTs)

Autor: Alexandra D. Carides, Karin Jordan, Richard J. Gralla, Bernardo Leon Rapoport, J. C. Street

Publikováno v: Journal of Clinical Oncology. 28:9057-9057

9057 Background: While improvements in the complete control of emesis with NK1s in pts receiving cisplatin (DDP) have been well demonstrated, efficacy reports of this antiemetic class in pts given carboplatin (carbo) or oxaliplatin (oxali) have only

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::126910f759613e4f18ec9a7c5a889b59
https://doi.org/10.1200/jco.2010.28.15_suppl.9057

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Cadmium uptake from feed and its distribution to food products of livestock

Autor: M. P. Verma, J. L. Shupe, J. C. Street, R. P. Sharma

Publikováno v: Environmental Health Perspectives

Distribution of cadmium (Cd) into the edible products of three species of food-producing animals was investigated during long-term dietary administration of supplemental cadmium chloride. Cows were exposed to 0.2 (control), 2.4, and 11.3 ppm Cd on wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a8c29a89cef538cd5bb2050a06ce10
https://doi.org/10.1289/ehp.792859

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Accumulation and Release of Chemicals by Adipose Tissue

Autor: J. C. Street, R. P. Sharma

Publikováno v: Comprehensive Physiology

The sections in this article are: 1 General Pharmacodynamics of Environmental Chemicals 2 Rates of Accumulation and Release for Different Chemicals 2.1 Short-Lived Chemicals 2.2 Long-Lived Chemicals 3 Physiological Factors in Accumulation and Release

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb70f4ebc4db88078e81402bdfcf6bfe
https://doi.org/10.1002/cphy.cp090130

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UPTAKE AND METABOLISM OF 1,3-DICHLOROPROPENE IN PLANTS

Autor: D. L. Berry, D. K. Salunkhe, J. C. Street, W. F. Campbell

Publikováno v: Journal of Food Safety. 2:247-255

Bush beans, carrots and tomatoes were shown to absorb 1,3-dichloro-propene from vermiculite, solution culture and sand. The dichloropro-pene was translocated and metabolized rapidly in the plant to 3-chloroallyl alcohol. The 3-chloroallyl alcohol its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c6e09b0a8be0f2a249897bfb22c6bec
https://doi.org/10.1111/j.1745-4565.1980.tb00401.x

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Drug effects on dieldrin storage in rat tissue

Autor: J C, Street, M, Wang, A D, Blau

Publikováno v: Bulletin of Environmental Contamination and Toxicology. 1:6-15

Selected drugs were tested for effectiveness in reducing dieldrin retention by rats. Female rats were fed diets treated to contain 1 ppm dieldrin. The drugs were administered as feed additives or by i.p. injections. The rats were sacrificed after 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945d228052db9a91adbee98d943e4fd8
https://doi.org/10.1007/bf01684070

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