Zobrazeno 1 - 10
of 33
pro vyhledávání: '"J. C. Makielski"'
Publikováno v:
Biophysical Journal. 65(2):790-798
Phasic block of rat cardiac Na+ current by saxitoxin was assessed using pulse trains and two-pulse voltage clamp protocols, and the results were fit to several kinetic models. For brief depolarizations (5 to 50 ms) the depolarization duration did not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d10330e88361140cf5ff3cf60631de
Autor:
J. C. Makielski, Zheng Fan
Publikováno v:
Circulation Research. 72:715-722
ATP-sensitive K+ current (IK.ATP) channels are thought to play a role in the K+ efflux observed in cardiac ischemia. Intracellular acidosis is a prominent early effect in ischemia; therefore, the effects of acidosis on IK.ATP may have certain pathoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565b9d626218e10e9da313229d1261a4
https://doi.org/10.1161/01.res.72.3.715
https://doi.org/10.1161/01.res.72.3.715
Publikováno v:
European Heart Journal. 12:4-9
The arrhythmogenic effects of ischaemia and reperfusion result from the complex interplay of normal ion channels reacting to the ischaemic environment, channels made abnormal by ischaemic modification, the appearance of new currents normally not pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe72b1a1cf73da194aaceddcafd77a83
https://doi.org/10.1093/eurheartj/12.suppl_f.4
https://doi.org/10.1093/eurheartj/12.suppl_f.4
Autor:
W L Nelson, J. C. Makielski
Publikováno v:
Circulation Research. 68:977-983
Heptanol blocks sodium current (INa) in nerve, but its effects on cardiac INa have not been well characterized. Block of INa by heptanol was studied in 16 internally perfused voltage-clamped cardiac Purkinje cells at reduced Na+ (45 mM outside, 0 mM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3700397be626e042223ae8e80f4df98f
https://doi.org/10.1161/01.res.68.4.977
https://doi.org/10.1161/01.res.68.4.977
Autor:
J. C. Makielski, E.M. Bugrij, T. Ivanovoch, C F Starmer, A.V. Mazaev, Vladislav V. Nesterenko, G.G. Beloshapko, L.V. Rosenshtraukh, E.P. Anyukhovsky
Publikováno v:
Journal of Molecular and Cellular Cardiology. 23:115-124
The frequency-dependent effects on the intraventricular conduction through the dog heart in situ produced by two class 1 antiarrhythmic drugs, ethacizin and lidocaine, with different kinetic properties were investigated. Conduction delay was measured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62bb7f670e51ae86d62a0e93476ac2aa
https://doi.org/10.1016/0022-2828(91)90030-p
https://doi.org/10.1016/0022-2828(91)90030-p
Publikováno v:
Journal of Molecular and Cellular Cardiology. 23:23-30
The effects of lysophosphatidylcholine (LPC) on Na channels have been investigated in inside-out patches of adult rat ventricular cells using the patch-clamp technique. Applying LPC (9–25 μ m ) to the inner side of the membrane reduced peak Na cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45a8d57fec172e316a8242c75064ba5
https://doi.org/10.1016/0022-2828(91)90020-m
https://doi.org/10.1016/0022-2828(91)90020-m
Publikováno v:
WMJ : official publication of the State Medical Society of Wisconsin. 105(3)
Transient left ventricular apical ballooning is a newly defined syndrome characterized by sudden onset of chest symptoms, electrocardiographic changes characteristic of myocardial ischemia, transient left ventricular dysfunction-particularly in the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::753e5cb53b3ae2afa67505b55493c7bb
https://pubmed.ncbi.nlm.nih.gov/16749326
https://pubmed.ncbi.nlm.nih.gov/16749326
Autor:
M J, Ackerman, B L, Siu, W Q, Sturner, D J, Tester, C R, Valdivia, J C, Makielski, J A, Towbin
Publikováno v:
JAMA. 286(18)
Fatal arrhythmias from occult long QT syndrome may be responsible for some cases of sudden infant death syndrome (SIDS). Because patients who have long QT syndrome with sodium channel gene (SCN5A) defects have an increased frequency of cardiac events
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0bce0dba4114dad106151d2cc8f5fdee
https://pubmed.ncbi.nlm.nih.gov/11710892
https://pubmed.ncbi.nlm.nih.gov/11710892
Publikováno v:
Molecular pharmacology. 57(1)
Flecainide block of Na(+) current (I(Na)) was investigated in wild-type (WT) or the long QT syndrome 3 (LQT3) sodium channel alpha subunit mutation with three amino acids deleted (DeltaKPQ) stably transfected into human embryonic kidney 293 cells usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b102cc3602a46a0cb9b55ae575fc7f39
https://pubmed.ncbi.nlm.nih.gov/10617684
https://pubmed.ncbi.nlm.nih.gov/10617684
Publikováno v:
Molecular pharmacology. 49(1)
Coexpression of the rat beta 1 subunit with rat brain and skeletal muscle sodium channel alpha subunits in Xenopus oocytes normalizes currents by accelerating sodium current decay kinetics, shifting steady state availability relationships, and accele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::40870e5a73b89dfc1a392859da6add92
https://pubmed.ncbi.nlm.nih.gov/8569709
https://pubmed.ncbi.nlm.nih.gov/8569709