Zobrazeno 1 - 10
of 250
pro vyhledávání: '"J. C. Lormeau"'
Publikováno v:
Blood Coagulation & Fibrinolysis. 8:161-167
The 'synthetic pentasaccharide', SR 90107A/Org 31540 (SP) representing the minimal AT-binding sequence of heparin is a catalyst of factor Xa inhibition. Affinity of SP, Sanorg 32701 (32701) and SR 80027 (80027), two close analogues of SP for rat, rab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ac9bef7791938cb5a89e320f854732
https://doi.org/10.1097/00001721-199704000-00002
https://doi.org/10.1097/00001721-199704000-00002
Publikováno v:
Blood Coagulation & Fibrinolysis. 8:175-184
This study was done to document further the mechanism of the antithrombotic effect of CY 216 after subcutaneous injection in the rabbit. We first measured the circulating anti-factor Xa and anti-thrombin activities expressed in either International U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8525751f294a9c8d26773f4347df89ea
https://doi.org/10.1097/00001721-199704000-00004
https://doi.org/10.1097/00001721-199704000-00004
Autor:
Maurice Petitou, J. C. Lormeau, Jacques P. Caen, Marc Pascal, Zhongchao Han, S. Bellucci, Z. X. Shen, J. P. Maffrand
Publikováno v:
Journal of Cellular Physiology. 168:97-104
We have previously reported that heparin is capable of stimulating in vitro and in vivo megakaryocytopoiesis in mice and has a thrombopoietic effect when given in chronic immune thrombocytopenic purpura and that heparin and several other glycosaminog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::197d211c84803b95cca0443e7c28435e
https://doi.org/10.1002/(sici)1097-4652(199607)168:1<97::aid-jcp12>3.0.co
https://doi.org/10.1002/(sici)1097-4652(199607)168:1<97::aid-jcp12>3.0.co
Autor:
J C Lormeau, J P Herault
Publikováno v:
Thrombosis and Haemostasis. 74:1474-1477
SummaryThe inhibition of thrombin generation (TG) was studied in plasma from human volunteers after single subcutaneous administrations of 4000, 8000 or 12,000 anti-Xa units (i.e., 6, 12 or 18 mg) of the synthetic pentasaccharide (SR 90107/ORG 31540)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f9799a233a6c846324dfcfbd4e4ff27
https://doi.org/10.1055/s-0038-1649968
https://doi.org/10.1055/s-0038-1649968
Publikováno v:
Thrombosis and Haemostasis. 72:862-868
SummaryFactor V activation is a critical step preceding prothrombinase formation. This study determined the contributions of factor Xa and thrombin, which activate purified factor V with similar catalytic efficiency, to plasma factor V activation dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44f59376f4afd6eb53960647e755d016
https://doi.org/10.1055/s-0038-1648975
https://doi.org/10.1055/s-0038-1648975
Autor:
Pierre-Alexandre Driguez, P. Duchaussoy, J. M. Herbert, Maurice Petitou, A. Bernat, J. C. Lormeau, J. P. Hérault
Publikováno v:
ChemInform. 30
In the early eighties, following breakthroughs in oligosaccharide chemistry, the total chemical synthesis of pentasaccharides has been achieved, representing the antithrombin binding domain of heparin (the active site). The selective inhibitors of co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82b1437985f306891dbc0aab092ce5ef
https://doi.org/10.1002/chin.199946273
https://doi.org/10.1002/chin.199946273
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 1:99-102
The synthesis of a pentasaccharide containing a N-acetyl-glucosamine unit and corresponding to the major natural sequence required in heparin for binding to antithrombin III is reported for the first time. This compound elicits anti-factor Xa activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6aff7811ca569a65e5338065860d7212
https://doi.org/10.1016/s0960-894x(00)80239-5
https://doi.org/10.1016/s0960-894x(00)80239-5
Publikováno v:
Annales pharmaceutiques francaises. 57(3)
In the early eighties, following breakthroughs in oligosaccharide chemistry, the total chemical synthesis of pentasaccharides has been achieved, representing the antithrombin binding domain of heparin (the active site). The selective inhibitors of co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55181e5300a066b4ac22ccdd9a0d7640
https://pubmed.ncbi.nlm.nih.gov/10427858
https://pubmed.ncbi.nlm.nih.gov/10427858
Autor:
J M, Herbert, J P, Hérault, A, Bernat, R G, van Amsterdam, J C, Lormeau, M, Petitou, C, van Boeckel, P, Hoffmann, D G, Meuleman
Publikováno v:
Blood. 91(11)
SANORG 34006 is a new sulfated pentasaccharide obtained by chemical synthesis. It is an analog of the "synthetic pentasaccharide" (SR 90107/ ORG 31540) which represents the antithrombin (AT) binding site of heparin. SANORG 34006 showed a higher affin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c4e5fccbe652bf0d53387986c5879b87
https://pubmed.ncbi.nlm.nih.gov/9596667
https://pubmed.ncbi.nlm.nih.gov/9596667
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 283(1)
Factor Xa, as with thrombin, binds to the clot and contributes to the propensity of thrombi to activate the coagulation system. The aim of this work was to compare the extent of prothrombinase inhibition produced by two factor Xa inhibitors: the anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d2c06ae99b252154be722eb7dcc8cbe
https://pubmed.ncbi.nlm.nih.gov/9336303
https://pubmed.ncbi.nlm.nih.gov/9336303