Zobrazeno 1 - 2
of 2
pro vyhledávání: '"J. C. Lagarde"'
Autor:
Farnaz Mohammadi, Shakthi Visagan, Sean M. Gross, Luka Karginov, J. C. Lagarde, Laura M. Heiser, Aaron S. Meyer
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
A tree-based adaptation of a hidden Markov model captures heterogeneity and cell state transitions based on single-cell lineages, enabling the study of intrinsic or drug-induced plasticity in heterogeneous cell populations.
Externí odkaz:
https://doaj.org/article/075379578e48489a8f9d4e2304bdc239
Autor:
Farnaz Mohammadi, Shakthi Visagan, Sean M. Gross, Luka Karginov, J. C. Lagarde, Laura M. Heiser, Aaron S. Meyer
Publikováno v:
Communications biology. 5(1)
Individual cells can assume a variety of molecular and phenotypic states and recent studies indicate that cells can rapidly adapt in response to therapeutic stress. Such phenotypic plasticity may confer resistance, but also presents opportunities to