Zobrazeno 1 - 10
of 23
pro vyhledávání: '"J. C. Fuscoe"'
Publikováno v:
Proceedings of the National Academy of Sciences. 92:831-835
Spontaneous and induced chromosomal breakage is an important cellular feature of Fanconi anemia (FA), an inherited DNA repair disorder characterized by progressive bone marrow failure, developmental abnormalities, and predisposition to leukemia. We h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7525a6a11f23caa96b300570e63054fa
https://doi.org/10.1073/pnas.92.3.831
https://doi.org/10.1073/pnas.92.3.831
The Chinese hamster HPRT gene: Restriction map, sequence analysis, and multiplex PCR deletion screen
Publikováno v:
Genomics. 9:247-256
The fine structure of the Chinese hamster hypoxanthine guanine phosphoribosyltransferase (HPRT) gene has been determined; the gene has nine exons and is dispersed over 36 kb DNA. Exons 2–9 are contained within overlapping λ bacteriophage clones an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1ca0e2d053cf41bbb1aec5d905ad9f
https://doi.org/10.1016/0888-7543(91)90249-e
https://doi.org/10.1016/0888-7543(91)90249-e
Publikováno v:
Environmental and molecular mutagenesis. 36(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54ae841b54a0ad7bf14a47cf05546eb5
https://pubmed.ncbi.nlm.nih.gov/11044907
https://pubmed.ncbi.nlm.nih.gov/11044907
Publikováno v:
Environmental and molecular mutagenesis. 29(1)
V(D)J recombinase is normally involved in the highly regulated rearrangement of immunoglobulin and T-cell-receptor gene segments (in B and T cells, respectively) to form functional antibody genes and T-cell-receptor genes. Occasionally, this tightly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb1f7711833873ba0b06d8cdf0af2524
https://pubmed.ncbi.nlm.nih.gov/9020304
https://pubmed.ncbi.nlm.nih.gov/9020304
Publikováno v:
Blood. 88(6)
Etoposide is one of the most widely used antineoplastics. Unfortunately, the same treatment schedules associated with impressive efficacy are associated with an increased risk of secondary acute myeloid leukemia (AML), which has prompted its withdraw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::142c1353822868ef080635f440af8a8d
https://pubmed.ncbi.nlm.nih.gov/8822941
https://pubmed.ncbi.nlm.nih.gov/8822941
Publikováno v:
Environmental and molecular mutagenesis. 27(1)
Chlorination is a widely used method for disinfection of drinking water supplies. Reaction of chlorine with naturally present organic compounds can result in toxic by-products. One major disinfection by-product from the chlorination of drinking water
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5265676795ca6ccb2cf828493319a354
https://pubmed.ncbi.nlm.nih.gov/8625942
https://pubmed.ncbi.nlm.nih.gov/8625942
Publikováno v:
Radiation research. 141(1)
We have examined the extent of HPRT- total gene deletions in three mutant collections: spontaneous and X-ray-induced deletions in TK6 human B lymphoblasts, and HPRT- deletions arising in vivo in T cells. A set of 13 Xq26 STS markers surrounding hprt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5f26a9d9fcbda9d8b1458ae92dd6bad6
https://pubmed.ncbi.nlm.nih.gov/7997511
https://pubmed.ncbi.nlm.nih.gov/7997511
Autor:
J C Fuscoe, T W Smith, Karen Harrington-Brock, R B Everson, Martha M. Moore, L P Burnette, L J Zimmerman, J.P. O'Neill
Publikováno v:
Environmental Health Perspectives
Somatic mutations have been implicated as critical early events in carcinogenesis. Point mutations, deletions, and translocation events have been shown to activate oncogenes or inactivate suppressor oncogenes. In human population monitoring, quantita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fd3387456c60119263ec0b4148c6c4
https://pubmed.ncbi.nlm.nih.gov/8143621
https://pubmed.ncbi.nlm.nih.gov/8143621
Autor:
Richard F. Branda, Richard J. Albertini, T R Skopek, Janice A. Nicklas, J C Fuscoe, J.P. O'Neill
Publikováno v:
Environmental Health Perspectives
Mutations arising in vivo in recorder genes of human blood cells provide biomarkers for molecular epidemiology by serving as surrogates for cancer-causing genetic changes. Current markers include mutations of the glycophorin-A (GPA) or hemoglobin (Hb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749d40e4800299f0387e1a940b520f32
https://pubmed.ncbi.nlm.nih.gov/8319611
https://pubmed.ncbi.nlm.nih.gov/8319611
Publikováno v:
Mutation research. 269(2)
Molecular alterations were examined in the hypoxanthine guanine phosphoribosyltransferase (hprt) gene of 41 independent X-ray-induced thioguanine-resistant (TGR) Chinese hamster ovary (CHO) cell clones. Rapid screening of the clones by multiplex poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aba90be39ebb278e11f1cdb6904f6f6
https://pubmed.ncbi.nlm.nih.gov/1383700
https://pubmed.ncbi.nlm.nih.gov/1383700