Zobrazeno 1 - 10
of 12
pro vyhledávání: '"J. C. Culberson"'
Web Enabling Technology for the Design, Enumeration, Optimization and Tracking of Compound Libraries
Autor:
Subhas J. Chakravorty, John F. Conway, Bryan Kraker, Bradley P. Feuston, Joseph Forbes, Ralph T. Mosley, J. C. Culberson, Robert P. Sheridan, Georgia B. McGaughey, Craig W. Lindsley, Simon K. Kearsley, Patricia A. Lennon, Mario Valenciano
Publikováno v:
Current Topics in Medicinal Chemistry. 5:773-783
Motivated by the need to augment Merck's in-house small molecule collection, web-based tools for designing, enumerating, optimizing and tracking compound libraries have been developed. The path leading to the current version of this Virtual Library T
Publikováno v:
The Journal of Organic Chemistry. 63:2591-2596
The first synthesis of 1,19-aza-1,19-desoxy-avermectin B(1a) (2) is described. This new macrolactam, prepared efficiently from avermectin B(1a) (1a) in seven steps, was designed to form an intramolecular hydrogen bond between the amide carbonyl and t
Autor:
P D, Williams, P S, Anderson, R G, Ball, M G, Bock, L, Carroll, S H, Chiu, B V, Clineschmidt, J C, Culberson, J M, Erb, B E, Evans
Publikováno v:
Journal of Medicinal Chemistry. 37:565-571
Modifications to the previously reported spiroindenylpiperidine camphor-sulfonamide oxytocin (OT) antagonist L-366,509 have produced a new series of o-tolylpiperazine (TP) camphor-sulfonamides. A number of analogues in the TP series that incorporate
Autor:
Erb Jm, Douglas J. Pettibone, D. S. Perlow, S.-H. L. Chiu, Peter D. Williams, Roger M. Freidinger, Mark G. Bock, L. A. Carroll, Steven M. Pitzenberger, Michael J. Kaufman, J. C. Culberson, B. E. Evans, J. S. Murphy, G. F. Lundell, S. L. Fitzpatrick, Bradley V. Clineschmidt, Joseph M. Pawluczyk, Richard G. Ball, P. S. Anderson
Publikováno v:
ChemInform. 25
Publikováno v:
ChemInform. 29
The first synthesis of 1,19-aza-1,19-desoxy-avermectin B(1a) (2) is described. This new macrolactam, prepared efficiently from avermectin B(1a) (1a) in seven steps, was designed to form an intramolecular hydrogen bond between the amide carbonyl and t
Autor:
J. C. Culberson, M. G. Axel, Arun K. Ghosh, Paula M.D. Fitzgerald, P. S. Anderson, Wayne J. Thompson, Joel R. Huff, S. P. Mckee
Publikováno v:
Journal of Medicinal Chemistry. 37:2506-2508
Autor:
M J, Bogusky, J C, Culberson, S M, Pitzenberger, V M, Garsky, A, Wallace, A, Pessi, K S, Koblan
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 54(1)
Farnesyl-protein transferase (FPTase) catalyzes the posttranslational farnesylation of the cysteine residue located in the C-terminal tetrapeptide of the Ras oncoprotein. Prenylation of this residue is essential for membrane association and cell-tran
Publikováno v:
Methods in enzymology. 275
Autor:
Douglas J. Pettibone, J. C. Culberson, Doug W. Hobbs, R. M. Freidinger, Peter D. Williams, N. P. Gould, Bradley V. Clineschmidt, James B. Hoffman, D. F. Veber
Publikováno v:
Peptides 1994 ISBN: 9789072199218
Peptides 1994
Peptides 1994
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0dda56b1f00fc1da95fb17a86238515
https://doi.org/10.1007/978-94-011-1468-4_326
https://doi.org/10.1007/978-94-011-1468-4_326
Publikováno v:
Nucleic acids research. 22(8)
The importance of RNA secondary structure on HIV-1 reverse transcriptase catalyzed polymerization and on the potency of the pyridin-2-one inhibitor 3-(4,7-dichlorobenzoxazol-2-ylmethylamino)-5-ethyl-6-meth ylpyridin-2(1H)-one, L-697,661, were investi