Zobrazeno 1 - 10
of 41
pro vyhledávání: '"J. C. Breliere"'
Autor:
David Shire, J. C. Breliere, Daniel Caput, Francis Barth, Michel Heaulme, P. Ferrara, Gérard Le Fur, Murielle Rinaldi-Carmona, Christian Congy, Jeanne Maruani, Serge Martinez, Philippe Soubrie, Bernard Calandra, Gervais Neliat
Publikováno v:
FEBS Letters. 350:240-244
SR141716A is the first selective and orally active antagonist of the brain cannabinoid receptor. This compound displays nanomolar affinity for the central cannabinoid receptor but is not active on the peripheral cannabinoid receptor. In vitro, SR1417
Autor:
Pierre Perreaut, Bernard Ferrari, G. Le Fur, C. Bernhart, A. Roccon, Catherine Cazaubon, P. Guiraudou, Dino Nisato, J. Taillades, J. C. Breliere, Jean Gougat
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:45-50
The application of acidic heterocycles as a substitute for tetrazole in the synthesis of potent non-peptide Angiotensin II AT1 receptor antagonists is described.
Autor:
J. C. Breliere, R Paul, Christiane Gueudet, Régis Steinberg, S Lavastre, J P Terranova, Martine Poncelet, J Guitard, Vincent Santucci, Philippe Soubrie
Publikováno v:
Neuropharmacology. 32:605-615
The biochemical, electrophysiological and behavioural effects of SR 31742A, a novel and selective ligand of sigma sites in brain, labelled with (+)-[ 3 H]3PPP ( K i = 5.3 ± 0.3 nM), were investigated in rodents and compared with those of DA antagoni
Autor:
J. C. Breliere, Bernard Ferrari, G. Le Fur, A. Roccon, Pierre Perreaut, Dino Nisato, Catherine Cazaubon, P. Guiraudou, Jean Gougat, C. Bernhart, J. Taillades
Publikováno v:
ChemInform. 25
The application of acidic heterocycles as a substitute for tetrazole in the synthesis of potent non-peptide Angiotensin II AT1 receptor antagonists is described.
Autor:
M, Rinaldi-Carmona, C, Congy, J, Simiand, F, Oury-Donat, P, Soubrie, J C, Breliere, G, Le Fur
Publikováno v:
Molecular pharmacology. 43(1)
Adaptive changes in 5-hydroxytryptamine (5-HT)2 receptors were investigated in mice after repeated administration of SR 46349B, a potent, selective, and competitive 5-HT2 receptor antagonist (Kl = 0.72 +/- 0.05 nM). Repeated administration (twice per
Autor:
M, Rinaldi-Carmona, C, Congy, V, Santucci, J, Simiand, B, Gautret, G, Neliat, B, Labeeuw, G, Le Fur, P, Soubrie, J C, Breliere
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 262(2)
A new potent, selective and p.o. active serotonergic [5-hydroxytryptamine (5-HT2)] receptor antagonist, SR 46349B [trans, 4-([3Z)3-(2-dimethylaminoethyl)oxyimino-3(2-flurophenyl++ +)propen-1-yl]phenol hemifumarate) has been characterized by a series
Publikováno v:
Drugs of the Future. 20:701
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 12:483-489
The Grignard reagent made from p-cyclohexyl m-chloroiodobenzene is carbonated with 14CO2 to give 3-chloro 4-cyclohexyl benzoǐc acid (radioactive yield 50 %). This acid is transformed into the corresponding chloride with thionyl chloride. Condensatio
Publikováno v:
Annals of the Rheumatic Diseases. 45:67-74
We studied the course of adjuvant arthritis in rats by measuring clinical, biochemical, and histological parameters on day 36 after induction (representing the secondary reaction) and on day 171, which is at the stage of permanent deformity. The effe
Publikováno v:
Agents and Actions. 15:103-105