Zobrazeno 1 - 10
of 20
pro vyhledávání: '"J. C. Azizkhan"'
Publikováno v:
Proceedings of the National Academy of Sciences. 88:8572-8576
Dihydrofolate reductase (DHFR; EC 1.5.1.3) is required in folate metabolism for the synthesis of purines, thymidine, and glycine. Although there have been several reports of induction of DHFR enzyme by methotrexate (MTX), a drug that competitively in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcb52538e3847902dcbb7dca8d6a3ea
https://doi.org/10.1073/pnas.88.19.8572
https://doi.org/10.1073/pnas.88.19.8572
Publikováno v:
Molecular and Cellular Biology. 10:2111-2121
We have determined the complete nucleotide sequence of rat transforming growth factor alpha (TGF alpha) mRNA and characterized the six exons that encode this transcript. These six exons span approximately 85 kilobases of genomic DNA, with exons 1 to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b45e86c11c4105df89a7c72b25e3a12
https://doi.org/10.1128/mcb.10.5.2111-2121.1990
https://doi.org/10.1128/mcb.10.5.2111-2121.1990
Publikováno v:
Journal of cellular biochemistry. 67(1)
Dihydrofolate reductase activity is required for many biosynthetic pathways including nucleotide synthesis. Its expression is therefore central to cellular growth, and it has become a key target for cancer chemotherapy. Transcription of the dihydrofo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11c4b908bfc4a451eb0f2376d3c70bf6
https://pubmed.ncbi.nlm.nih.gov/9328836
https://pubmed.ncbi.nlm.nih.gov/9328836
Publikováno v:
Oncogene. 9(11)
Transcription from the rat TGF alpha promoter initiates at two predominant sites (-188 and -58) in a G+C-rich region that does not contain TATA or CAAT motifs. Previous studies using transfected reporter constructs implicated the transcription factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a938e77fc144c17cd527df3b3c3c3594
https://pubmed.ncbi.nlm.nih.gov/7936640
https://pubmed.ncbi.nlm.nih.gov/7936640
Publikováno v:
Critical reviews in eukaryotic gene expression. 3(4)
The promoters of many of the genes encoding the so-called "housekeeping" enzymes, oncogenes, growth factors and their receptors, and transcription factors, do not contain a canonical TATA box, which is known to direct transcription initiation. The me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5640606084a0149292712d50546cca4c
https://pubmed.ncbi.nlm.nih.gov/8286846
https://pubmed.ncbi.nlm.nih.gov/8286846
Adenovirus E1A-dependent trans activation of the adenovirus E2 gene involves the activation of the cellular transcription factor E2F. E2F binding sites have also been identified in the 5'-flanking region of a number of cellular genes, raising the pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44b9d10ad01cd267855a2ba72df8525
https://europepmc.org/articles/PMC241350/
https://europepmc.org/articles/PMC241350/
We have determined the complete nucleotide sequence of rat transforming growth factor alpha (TGF alpha) mRNA and characterized the six exons that encode this transcript. These six exons span approximately 85 kilobases of genomic DNA, with exons 1 to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe465bf99b1f0cc54baff82d1b4b63da
Publikováno v:
Scandinavian Journal of Immunology. 8:527-532
The BeWo line of human choriocarcinoma has been studied in an attempt to understand the phased expression of AP in normal placenta and genome derepression in certain cancers. Be Wo contains at least two species of AP. The major activity is heat-stabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d91028221b51cbca8320fa5b5d28d42
https://doi.org/10.1111/j.1365-3083.1978.tb03972.x
https://doi.org/10.1111/j.1365-3083.1978.tb03972.x
Publikováno v:
In Vitro. 14:631-638
Human trophoblast isolation and cell culture procedures were examined to identify variables that enhance secretion of chorionic gonadotropin (HCG) in primary culture. Brief exposure of unminced first-trimester placental specimens to a solution of try
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f4e944f28a75b2d976585d4a541ef4
https://doi.org/10.1007/bf02617924
https://doi.org/10.1007/bf02617924
Publikováno v:
Biochemistry. 25:6228-6236
We have sequenced the 1240 base pairs (bp) upstream from the translation start site of the hamster dihydrofolate reductase (DHFR) gene. The DNA in the 5' flanking region contains several elements that are homologous in both sequence and relative loca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2557b488a15ba6755119db88e45165a
https://doi.org/10.1021/bi00368a059
https://doi.org/10.1021/bi00368a059