Zobrazeno 1 - 10
of 12
pro vyhledávání: '"J. C. Avenant"'
Publikováno v:
European Journal of Clinical Pharmacology. 41:517-519
We have used systolic time intervals (STI) to measure inotrophy and chronotropy as indirect measures of the actions of noradrenaline, in order to ascertain whether the depletion of cardiac noradrenaline stores which has been shown to occur in laborat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef797b4b0b6b913ca8cb17554b4fa3e
https://doi.org/10.1007/bf00314977
https://doi.org/10.1007/bf00314977
Publikováno v:
British Journal of Clinical Pharmacology. 29:254-256
The influence of autonomic blockers on the heart rate of ten Bushmen and eight White volunteers was studied. There were significant differences in heart rate response to atropine alone between the White's and Bushmen. However, after prior beta-adreno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad39e10f0714f21c0adf90bdf447774
https://doi.org/10.1111/j.1365-2125.1990.tb03629.x
https://doi.org/10.1111/j.1365-2125.1990.tb03629.x
Publikováno v:
Humanexperimental toxicology. 10(3)
1 This study has found no occurrence of poor metabolism of sparteine within a South African Venda populaton of 97 subjects. 2 On the basis of MR (metabolic ratio) the mean and distribution of the results are very similar to those found in Ghanaians.5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2ef5f2106c9d306dfd937c4b24c3b8
https://pubmed.ncbi.nlm.nih.gov/1678945
https://pubmed.ncbi.nlm.nih.gov/1678945
Publikováno v:
European journal of clinical pharmacology. 39(3)
The purpose of this controlled study was to study the effect of cimetidine and ranitidine on the myocardium of 8 healthy male volunteers using systolic time intervals. Ranitidine caused a significant decrease in the QS2I, as from 40 min indicating a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955fb40b24a57774a2715cf71c7aeae0
https://pubmed.ncbi.nlm.nih.gov/2257871
https://pubmed.ncbi.nlm.nih.gov/2257871
Publikováno v:
European Journal of Clinical Pharmacology. 40:317-318
The calcium antagonist falipamil, a chemical congener of verapamil, has anticholinergic properties. It was decided to study the interaction of verapamil with the anticholinergic drugs, atropine and pirenzepine, using healthy male volunteers. After at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80bc9e0a7b24423bf4870ad511ee4637
https://doi.org/10.1007/bf00315218
https://doi.org/10.1007/bf00315218
Publikováno v:
Human Toxicology. 8:365-368
1 The metabolic 4-hydroxylation of debrisoquine has been studied in a group of 98 black African villagers in Vendaland. 2 The metabolic α-hydroxylation of metoprolol has been studied in 94 of the same black African villagers. 3 A 4% prevalence of po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767c52c4a7aad7b2bb0cbbbae27ec70f
https://doi.org/10.1177/096032718900800506
https://doi.org/10.1177/096032718900800506
Publikováno v:
Human toxicology. 7(3)
1 The metabolic oxidation of debrisoquine has been studied in a group of 96 San Bushmen. 2 The amounts of debrisoquine and 4-hydroxy-debrisoquine excreted in 0-8 h urine were measured and the metabolic ratio (% dose as debrisoquine/% dose as 4-hydrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb1d12d3d37e69494c4774344080b9b
https://pubmed.ncbi.nlm.nih.gov/3391625
https://pubmed.ncbi.nlm.nih.gov/3391625
Publikováno v:
Human toxicology. 8(1)
1 The metabolic oxidation of metoprolol has been studied in a group of 98 San Bushmen. 2 The amounts of metoprolol and α-hydroxy metoprolol excreted in 0-8 h urine collection, after dosing with 100 mg metoprolol, were measured and the metabolic rati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118e13c63d4fe6386f4faebbfe6e5895
https://pubmed.ncbi.nlm.nih.gov/2714809
https://pubmed.ncbi.nlm.nih.gov/2714809
Publikováno v:
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 64(15)
A baboon model was used to investigate the effects of atenolol, nadolol, sotalol and labetalol on renal function. The glomerular filtration rate (GFR) and renal blood flow (RBF) were measured, using radionuclides and a gamma camera, before and after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b7a03421e47bf802615a8d53b2b2607
https://pubmed.ncbi.nlm.nih.gov/6137878
https://pubmed.ncbi.nlm.nih.gov/6137878
Publikováno v:
Human toxicology. 6(2)
1 The excretion of antipyrine metabolites over 48 h as percentage dose and the antipyrine kel and metabolite formation rate constants have been measured for 20 healthy Venda Africans. 2 To allow comparison with published data from inter-ethnic studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a71802f66abbaabe32310edd0efe4ad
https://pubmed.ncbi.nlm.nih.gov/3557469
https://pubmed.ncbi.nlm.nih.gov/3557469