Výsledky vyhledávání - "J. C Cigudosa"

Akademický článek

Genetic Heterogeneity of Benign Thyroid Lesions

Autor: O. Ferrer-Roca, J. A. Pérez-Gómez, J. C. Cigudosa, E. Gómez, M. Estévez

Publikováno v: Analytical Cellular Pathology, Vol 16, Iss 2, Pp 101-110 (1998)

The present series includes 75 thyroid lesions (38 goiters, 30 adenomas, 3 follicullo‐papillary encapsulated carcinomas and 4 normal thyroid) that were studied by static and flow cytometry. Four cases were also analyzed by in situ hybridization (ce

Externí odkaz: https://doaj.org/article/8bcc178442be44b1b803159d322f4d96

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Mutational Screening of BRCA1/2 Genes as a Predictive Factor for Therapeutic Response in Epithelial Ovarian Cancer: A Consensus Guide from the Spanish Society of Pathology (SEAP-IAP) and the Spanish Society of Human Genetics (AEGH)

Autor: Xavier Matias-Guiu, I de Juan, B Bellosillo, Conxi Lázaro, Ana Osorio, Juan Manuel Rosa-Rosa, F Rojo, J C Cigudosa, J Palacios, M de la Hoya, Sarai Palanca

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
VIRCHOWS ARCHIV
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Virchows Archiv

Germline/somatic BRCA-mutated ovarian carcinomas (OC) are associated to have better response with platinum-based chemotherapy and long-term prognosis than non-BRCA-associated OCs. In addition, these mutations are predictive factors to response to Pol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589e89b657a2759ec394257398437768
http://hdl.handle.net/2445/173284

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Truncated RUNX1 protein generated by a novel t(1;21)(p32;q22) chromosomal translocation impairs the proliferation and differentiation of human hematopoietic progenitors

Autor: Javier Suela, Francesco Acquadro, Marta Casado Martín, J C Cigudosa, Sandra Rodriguez-Perales, Juan C. Ramirez, Sara Alvarez, Raúl Torres-Ruiz, E Yebra

Publikováno v: Oncogene. 35:125-134

We have identified a new t(1;21)(p32;q22) chromosomal translocation in a MDS/AML patient that results in expression of an aberrant C-terminally truncated RUNX1 protein lacking several regulatory domains. As similar truncated RUNX1 proteins are genera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82469bf1a3e98dd8e0c4154384b2c369
https://doi.org/10.1038/onc.2015.70

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PS1146 LOW-COVERAGE WHOLE GENOME SEQUENCING OUTPERFORMS FISH IN COPY NUMBER VARIATION DETECTION IN CHRONIC LYMPHOCYTIC LEUKEMIA

Autor: M.J. Larrayoz, I. Vazquez, J. Rifón, P. Sanchez-Jimenéz, J.M. Arguiñano, B. Ariceta, A. Aguilera-Díaz, S. Palomino-Echeverría, Z. Blasco-Iturri, Marta Fernandez-Mercado, A. Mañú, J C Cigudosa, María José Calasanz, A. Irigoyen-Barranco, Amaia Vilas-Zornoza, David Lara-Astiaso, P. San Martin-Uriz, Felipe Prosper

Publikováno v: HemaSphere. 3:519

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e607f2a125f02f6ae63232b4e19baf16
https://doi.org/10.1097/01.hs9.0000562868.12249.a2

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Exome sequencing reveals novel and recurrent mutations with clinical impact in blastic plasmacytoid dendritic cell neoplasm

Autor: Sara Alvarez, J.M. Hernández-Rivas, María José Larrayoz, M Wiseman, Gonzalo Gómez-López, David G. Pisano, Juliane Menezes, Rosa Ayala, L F Brichs, Rocio N. Salgado, Ismael Buño, Francesco Acquadro, Maria-Jose Calasanz, J C Cigudosa, Marta González-Vicent, J G Talavera-Casañas, José Cervera, M A Piris, Santiago Montes-Moreno

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Leukemia
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a very rare disease that currently lacks genomic and genetic biomarkers to assist in its clinical management. We performed whole-exome sequencing (WES) of three BPDCN cases. Based on these data,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6da903e17fc1c3c78581f96e973ff0
https://doi.org/10.1038/leu.2013.283

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Genome-Wide Analysis of DNA Copy Number Changes in Liver Steatosis

Autor: J. J. Echevarria, A. Zabala, F. Royo, F. Acquadro, J. C. Cigudosa, J. L. Zugaza, I. Zabalza, N. Paz, Luis Antonio Parada

Publikováno v: British Journal of Medicine and Medical Research. 3:1773-1785

Aims: Liver steatosis is the most common benign form of non-alcoholic fatty liver disease. It might be a risk factor for hepatocellular carcinoma, either (i) by causing fibrosis, which highly predisposes to hepatoma, or (ii) by being an early precurs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00cf478ede888ddef234b4cb44a8f69c
https://doi.org/10.9734/bjmmr/2013/2543

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Chromosomal abnormalities clustering in multiple myeloma reveals cytogenetic subgroups with nonrandom acquisition of chromosomal changes

Autor: Borja Saez, F Guillén-Grima, Reiner Siebert, J C Cigudosa, Lana Harder, José I. Martín-Subero, María D. Odero, Maria-Jose Calasanz, Felipe Prosper

Publikováno v: Leukemia. 18:654-657

Chromosomal abnormalities clustering in multiple myeloma reveals cytogenetic subgroups with nonrandom acquisition of chromosomal changes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db19c28cee50e4fc06d063589093152a
https://doi.org/10.1038/sj.leu.2403256

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t(2;5) Associated with a Histiocytic-Monocytic Neoplasm

Autor: J. C Cigudosa, S De La Iglesia, T. Molero, A. Lemes, C Santana, Estella Matutes

Publikováno v: Leukemia & Lymphoma. 41:429-433

We describe a patient with a neoplasm derived from the histiocytic-monocytic lineage associated with t(2;5) detected by FISH. The patient presented with bone marrow involvement, no organomegaly and subsequently developed a leukaemic picture. The clin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a591416f93df82b7b167146d05874ca8
https://doi.org/10.3109/10428190109058000

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Genetic Heterogeneity of Benign Thyroid Lesions

Autor: E. Gomez, J. A. Pérez-Gómez, M. Estevez, J. C. Cigudosa, Olga Ferrer-Roca

Publikováno v: Analytical Cellular Pathology, Vol 16, Iss 2, Pp 101-110 (1998)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b187283ad263c36c0589a0cd56ac9a25
https://doaj.org/article/8bcc178442be44b1b803159d322f4d96

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MYC antagonizes the differentiation induced by imatinib in chronic myeloid leukemia cells through downregulation of p27(KIP1.)

Autor: M T, Gómez-Casares, E, García-Alegria, C E, López-Jorge, N, Ferrándiz, R, Blanco, S, Alvarez, J P, Vaqué, G, Bretones, J M, Caraballo, P, Sánchez-Bailón, M D, Delgado, J, Martín-Perez, J C, Cigudosa, J, León

Publikováno v: Gomez-Casares, MT, Garcia Alegria, E, Lopez-Jorge, C E, Ferrandiz, N, Blanco, R, Alvarez, S, Vaque, J P, Bretones, G, Caraballo, J M, Sánchez-Bailón, P, Delgado, M D, Martin-Perez, J, Cigudosa, JC & León, J 2013, ' MYC antagonizes the differentiation induced by imatinib in chronic myeloid leukemia cells through downregulation of p27(KIP1.). ', Oncogene, vol. 32, pp. 2239-2246 . https://doi.org/10.1038/onc.2012.246

Chronic myeloid leukemia (CML) progresses from a chronic to a blastic phase where the leukemic cells are proliferative and undifferentiated. The CML is nowadays successfully treated with BCR-ABL kinase inhibitors as imatinib and dasatinib. In the CML

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e68188e5c9a4f1575cd1d5795d965d
https://www.research.manchester.ac.uk/portal/en/publications/myc-antagonizes-the-differentiation-induced-by-imatinib-in-chronic-myeloid-leukemia-cells-through-downregulation-of-p27kip1(a3a35609-ea6e-455a-85a8-85c71f934e1f).html

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