Zobrazeno 1 - 10
of 233
pro vyhledávání: '"J. Buttle"'
Publikováno v:
Hydrology and Earth System Sciences, Vol 22, Pp 3965-3981 (2018)
As northern environments undergo intense changes due to a warming climate and altered land use practices, there is an urgent need for improved understanding of the impact of atmospheric forcing and vegetation on water storage and flux dynamics in
Externí odkaz:
https://doaj.org/article/b77d64c780aa4dd6827b76095acf5615
Publikováno v:
Hydrology and Earth System Sciences, Vol 20, Iss 7, Pp 2811-2825 (2016)
There are growing numbers of studies on climate change impacts on forest hydrology, but limited attempts have been made to use current hydroclimatic variabilities to constrain projections of future climatic conditions. Here we used historical wet and
Externí odkaz:
https://doaj.org/article/8efb91fcba904fa4aae03aa7b6716f37
Autor:
Tayla A. Rees, Benjamin J. Buttle, Zoe Tasma, Sung-Hyun Yang, Paul W. R. Harris, Christopher S. Walker
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Type 2 diabetes (T2D) and obesity are prevalent metabolic disorders affecting millions of individuals worldwide. A new effective therapeutic drug called tirzepatide for the treatment of obesity and T2D is a dual agonist of the GIP receptor and GLP-1
Externí odkaz:
https://doaj.org/article/0907ffccbaea49f58081214071b5e048
Autor:
Katherine A. Staines, Ekele Ikpegbu, Anna E. Törnqvist, Scott Dillon, Behzad Javaheri, Anish K. Amin, Dylan N. Clements, David J. Buttle, Andrew A. Pitsillides, Colin Farquharson
Publikováno v:
BMC Musculoskeletal Disorders, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, we examine whether dis
Externí odkaz:
https://doaj.org/article/d38e50db61e14135b3a5070ed6bef26f
Akademický článek
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Autor:
Jerzy M. Behnke, Iain L. Johnstone, Oumu Diallo, Tim Winks, Ann Lowe, Ian R. Duce, Victor S. Njom, David J. Buttle, Mark J. Dickman
Publikováno v:
Parasites & Vectors, Vol 14, Iss 1, Pp 1-11 (2021)
Parasites & Vectors
Parasites & Vectors
Background Plant-derived cysteine proteinases of the papain family (CPs) attack nematodes by digesting the cuticle, leading to rupture and death of the worm. The nematode cuticle is composed of collagens and cuticlins, but the specific molecular targ
Publikováno v:
Heliyon, Vol 7, Iss 10, Pp e08125-(2021)
Heliyon
Heliyon
Plant derived cysteine proteinases (CPs) have long been known to possess anthelmintic properties but have attracted renewed attention recently because of the acute need to discover novel methods for controlling helminth infections as a result of incr
Autor:
Suneel S. Apte, Yaoyao Du, Carolyn M. Dancevic, Courtney M. Nelson, David J. Buttle, Timothy J. Mead, Judith A. Drazba, Mireille Vankemmelbeke, Ndeye Aicha Gueye
Publikováno v:
Cell Reports, Vol 23, Iss 2, Pp 485-498 (2018)
Cell reports
Cell reports
SUMMARY Focal adhesions anchor cells to extracellular matrix (ECM) and direct assembly of a pre-stressed actin cytoskeleton. They act as a cellular sensor and regulator, linking ECM to the nucleus. Here, we identify proteolytic turnover of the anti-a
Autor:
James W.F. Catto, Massimiliano Mellone, Daniel W. Lambert, Ricardo D. Coletta, Stephen S. Prime, Priyanka Prajapati, Gareth J. Thomas, Emma E. Hinsley, E. Ken Parkinson, David J. Buttle, Siti A Abidin, Genevieve E Melling, Stuart Hunt, Sarah E Flannery, Ian C. Paterson, Hannah Clemmens
Publikováno v:
Carcinogenesis. 39:798-807
The dissemination of cancer cells to local and distant sites depends on a complex and poorly understood interplay between malignant cells and the cellular and non-cellular components surrounding them, collectively termed the tumour microenvironment.
Autor:
Ekele Ikpegbu, Anish K. Amin, Behzad Javaheri, Scott Dillon, Andrew A. Pitsillides, Anna E. Törnqvist, Katherine Staines, Dylan N. Clements, David J. Buttle, Colin Farquharson
Publikováno v:
BMC Musculoskeletal Disorders
BMC Musculoskeletal Disorders, Vol 20, Iss 1, Pp 1-11 (2019)
Staines, K, Ikpegbu, E, Tornqvist, A, Dillon, S, Javaheri, B, Amin, A, Clements, D, Buttle, D, Pitsillides, A A & Farquharson, C 2019, ' Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis ', BMC Musculoskeletal Disorders, vol. 20, 344 . https://doi.org/10.1186/s12891-019-2731-9
BMC Musculoskeletal Disorders, Vol 20, Iss 1, Pp 1-11 (2019)
Staines, K, Ikpegbu, E, Tornqvist, A, Dillon, S, Javaheri, B, Amin, A, Clements, D, Buttle, D, Pitsillides, A A & Farquharson, C 2019, ' Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis ', BMC Musculoskeletal Disorders, vol. 20, 344 . https://doi.org/10.1186/s12891-019-2731-9
Background Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, we examine whether disruption t