Zobrazeno 1 - 10
of 679
pro vyhledávání: '"J. Buchsbaum"'
Autor:
Nikita Bhalerao, Asmi Chakraborty, Michael P. Marciel, Jihye Hwang, Colleen M. Britain, Austin D. Silva, Isam E. Eltoum, Robert B. Jones, Katie L. Alexander, Lesley E. Smythies, Phillip D. Smith, David K. Crossman, Michael R. Crowley, Boyoung Shin, Laurie E. Harrington, Zhaoqi Yan, Maigen M. Bethea, Chad S. Hunter, Christopher A. Klug, Donald J. Buchsbaum, Susan L. Bellis
Publikováno v:
JCI Insight, Vol 8, Iss 19 (2023)
The role of aberrant glycosylation in pancreatic ductal adenocarcinoma (PDAC) remains an under-investigated area of research. In this study, we determined that ST6 β-galactoside α2,6 sialyltransferase 1 (ST6GAL1), which adds α2,6-linked sialic aci
Externí odkaz:
https://doaj.org/article/8d74b6365a7e4f5aab8310300004ced9
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/c4865da2716a45ca9a244b4f67ec722f
Autor:
Antonio B. Ward, Adam B. Keeton, Xi Chen, Tyler E. Mattox, Alex B. Coley, Yulia Y. Maxuitenko, Donald J. Buchsbaum, Troy D. Randall, Gang Zhou, Gary A. Piazza
Publikováno v:
MedComm, Vol 1, Iss 2, Pp 121-128 (2020)
Abstract Approximately 30% of human cancers harbor a gain‐in‐function mutation in the RAS gene, resulting in constitutive activation of the RAS protein to stimulate downstream signaling, including the RAS‐mitogen activated protein kinase pathwa
Externí odkaz:
https://doaj.org/article/9aa12d1d00174415864d60bceb9ad752
Autor:
Kimberly S. Esham, Angie Mae Rodday, Hedy P. Smith, Farzad Noubary, Ruth Ann Weidner, Rachel J. Buchsbaum, Susan K. Parsons
Publikováno v:
Blood Advances, Vol 4, Iss 1, Pp 19-27 (2020)
Abstract: Sickle cell disease (SCD) is characterized by painful vaso-occlusive crises (VOCs). Self-reported pain intensity is often assessed with the Numeric Rating Scale (NRS), whereas newer patient-reported outcome measures (PROMs) assess multidime
Externí odkaz:
https://doaj.org/article/ba867d1868294808a3b68a1766f4143f
Autor:
Sumit Agarwal, Balabhadrapatruni V.S.K. Chakravarthi, Hyung-Gyoon Kim, Nirzari Gupta, Kevin Hale, Sai Akshaya Hodigere Balasubramanya, Patsy G. Oliver, Dafydd G. Thomas, Isam-Eldin A. Eltoum, Donald J. Buchsbaum, Upender Manne, Sooryanarayana Varambally
Publikováno v:
Translational Oncology, Vol 13, Iss 7, Pp 100776- (2020)
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with an extremely poor prognosis. There is an urgent need to identify new therapeutic targets and also understand the mechanism of PDAC progression that leads to aggressiveness of the di
Externí odkaz:
https://doaj.org/article/d7ab375b7a7644498e50aefc799cbb8e
Autor:
David W. Doo, Selene Meza-Perez, Angelina I. Londoño, Whitney N. Goldsberry, Ashwini A. Katre, Jonathan D. Boone, Dylana J. Moore, Cindy T. Hudson, Ilaria Betella, Tyler R. McCaw, Abhishek Gangrade, Riyue Bao, Jason J. Luke, Eddy S. Yang, Michael J. Birrer, Dmytro Starenki, Sara J. Cooper, Donald J. Buchsbaum, Lyse A. Norian, Troy D. Randall, Rebecca C. Arend
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 12 (2020)
Background: The Wnt/β-catenin pathway is linked to tumorigenesis in a variety of tumors and promotes T cell exclusion and resistance to checkpoint inhibitors. We sought to determine whether a small molecule inhibitor of this pathway, WNT974, would i
Externí odkaz:
https://doaj.org/article/9e744b8aa2274b79bb8a1c96027e50f5
Autor:
Jeremy B. Foote, Tyler E. Mattox, Adam B. Keeton, Forrest Smith, Kristly L. Berry, Antonio B. Ward, Karina J. Yoon, Sujith Sarvesh, Ganji P. Nagaraju, Yulia Maxuitenko, Xi Chen, Jacob Valiyaveettil, Julienne L. Carstens, Jennifer Yang, Donald J. Buchsbaum, Gang Zhou, Elmar Nurmmedov, Ivan Babic, Vadim Gaponenko, Hazem Abdelkarim, Michael R. Boyd, Bassel F. El-Rayes, Gary A. Piazza
Here we describe a novel class of pan-RAS inhibitor with highly potent and selective anticancer activity by killing cancer cells harboring mutations in RAS or with constitutively activated RAS resulting from mutations in upstream signaling components
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d76ea95ba86d6555f147a6ab3d6b4a1
https://doi.org/10.1101/2023.05.17.541233
https://doi.org/10.1101/2023.05.17.541233
TRA-8, a monoclonal antibody to death receptor 5 induces apoptosis in various cancer cells; however, the degree of sensitivity varies from highly sensitive to resistant. We have previously shown that resistance to TRA-8 can be reversed by using chemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b130ddabd0d52ec457ede9bb10e7e591
https://doi.org/10.1158/1541-7786.c.6542259.v1
https://doi.org/10.1158/1541-7786.c.6542259.v1
Autor:
David A. Boothman, Jinming Gao, Douglas R. Spitz, Donald J. Buchsbaum, William G. Bornmann, David M. Euhus, Cheryl Lewis, Michael Boatman, Amy Rommel, Zachary Moore, Lifen Cao, Malina Patel, Long Shan Li, John J. Pink, Vernon E. Anderson, Marie Varnes, Melissa C. Srougi, Kathryn E. Reinicke, Erik A. Bey
PDF file, 1661K, Supplemental Figure S1- Chemical Structures. Supplemental Figure S2-Oxygen Consumption in MCF-7 Cells treated with or without betalapchone and dicoumarol. Supplemental Figure S2 legend. Supplemental Figure S3-Survival assay for norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0292db08a0f90fe3921f701ed3216c
https://doi.org/10.1158/1535-7163.22498413.v1
https://doi.org/10.1158/1535-7163.22498413.v1
Supplementary Figures S1-S7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4dc753cf811be8ff7f313c82354d767
https://doi.org/10.1158/1541-7786.22519041.v1
https://doi.org/10.1158/1541-7786.22519041.v1