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A Combination Drug Treatment Against Ocular Sulfur Mustard Injury

Autor: Richard E. Sweeney, Michael C. Babin, Robyn B. Lee, Karen M. Ricketts, Michele Y. Gazaway, John J. Brozetti

Publikováno v: Journal of Toxicology: Cutaneous and Ocular Toxicology. 23:65-75

The eye is considered to be one of the most sensitive organs to sulfur mustard [bis(2‐chloroethyl) sulfide (SM)], with injuries ranging from mild conjunctivitis to advanced corneal disease. Even mild ocular involvement from sulfur mustard exposure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4d6d749906a7e7f52a1ef9c3df35403
https://doi.org/10.1081/cus-120027483

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The Distribution Kinetics of Topical14C‐Sulfur Mustard in Rabbit Ocular Tissues and the Effect of Acetylcysteine

Autor: Aharon Levy, M. Ross, Michael C. Babin, J. Brozetti, J. Turetz, Adina Amir, T. Logan, Karen M. Ricketts, Shira Chapman, Tamar Kadar

Publikováno v: Journal of Toxicology: Cutaneous and Ocular Toxicology. 22:201-214

Sulfur mustard (2,2‐dichlorodiethyl sulfide; HD), is a potent alkylating agent which in liquid or vapor form is capable of causing severe injuries to skin and respiratory tract, and was shown to cause short‐ and long‐term ocular injuries. N‐A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da1a4fb4a9d9b15dec52c8262623a40d
https://doi.org/10.1081/cus-120026300

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Homocysteine: a risk factor for retinal venous occlusive disease1,2 1The opinions or assertions contained in this article are the private views of the authors and are not to be construed as official or reflective of the views of the Department of the United States Army or the United States Department of Defense. 2The authors have no financial interest in any product described in this article

Autor: John S. B. Dick, Thomas P. Ward, Allen B. Thach, John J Brozetti, Bruce A. Brown, Jeffrey L. Marx, Rodney D Hollifield, Robin S. Howard

Publikováno v: Ophthalmology. 109:287-290

Purpose Recent studies have shown a relationship between elevated levels of homocysteine and vascular disease including cerebrovascular accidents and myocardial infarctions. We evaluated patients with a recent retinal vein occlusion to determine if t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d271bb0c83d72dbe59e8fc400664d3de
https://doi.org/10.1016/s0161-6420(01)00923-x

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Half Mustard (CEES) Induced Damage to Rabbit Cornea: Attenuating Effect of Taurine-Pyruvate-Alpha-Ketoglutarate-Pantothenate Mixture

Autor: Shambhu D. Varma, J. Brozetti, A.H. Ali, E. Lehnert, John P. Petrali, A. Weir, P.S. Devamanoharan

Publikováno v: Journal of Ocular Pharmacology and Therapeutics. 14:423-428

Studies have been conducted on the corneal damage by half mustard (2-chloroethyl-ethyl sulfide, CEES) and its possible prevention by a mixture of taurine, alpha-ketoglutarate, pyruvate and pantothenate. CEES has been found to damage the membrane perm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5a48916d298d354c6410ea637f3fd0
https://doi.org/10.1089/jop.1998.14.423

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Acute ocular effects of mustard gas: ultrastructural pathology and immunohistopathology of exposed rabbit cornea†

Autor: T. A. Hamilton, John P. Petrali, A. V. Finger, E. J. Dick, J. J. Brozetti

Publikováno v: Journal of Applied Toxicology. 20:S173-S175

Whole-body exposure to sulfur mustard (HD) produces cutaneous, respiratory and ocular impairment. Of these, ocular damage causes the most immediate incapacitation. Heretofore, characterization of HD ocular toxicity has been largely limited to gross a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f4e9a5906d2dc338da332871be01a69
https://doi.org/10.1002/1099-1263(200012)20:1+<::aid-jat679>3.0.co

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Homocysteine: a risk factor for retinal venous occlusive disease

Autor: Bruce A, Brown, Jeffrey L, Marx, Thomas P, Ward, Rodney D, Hollifield, John S, Dick, John J, Brozetti, Robin S, Howard, Allen B, Thach

Publikováno v: Ophthalmology. 109(2)

Recent studies have shown a relationship between elevated levels of homocysteine and vascular disease including cerebrovascular accidents and myocardial infarctions. We evaluated patients with a recent retinal vein occlusion to determine if there was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::76e370293ee45125664f366d4283447a
https://pubmed.ncbi.nlm.nih.gov/11825810

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Acute ocular effects of mustard gas: ultrastructural pathology and immunohistopathology of exposed rabbit cornea

Autor: J P, Petrali, E J, Dick, J J, Brozetti, T A, Hamilton, A V, Finger

Publikováno v: Journal of applied toxicology : JAT. 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54109af05dab7b799b262cbec160a1cd
https://pubmed.ncbi.nlm.nih.gov/11428631

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Central retinal vein occlusion in a patient with IgG lambda monoclonal gammopathy

Autor: Robert W. Enzenauer, John J. Brozetti, Robert A. Dragoo

Publikováno v: Archives of ophthalmology (Chicago, Ill. : 1960). 117(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72af9706740693c24ca3bcae567fd32
https://pubmed.ncbi.nlm.nih.gov/9930181

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Corneal damage by half mustard (2-chloroethyl ethyl sulfide, CEES) in vitro preventive studies: a histologic and electron microscopic evaluation

Autor: A.H. Ali, E. Lehnert, J. Brozetti, Shambhu D. Varma, P.S. Devamanoharan, John P. Petrali, M. Henein

Publikováno v: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 14(5)

The effect of half-mustard (2-chloroethyl ethyl sulfide, CEES) on the morphology and ultrastructure of the cornea has been studied in vitro. Extensive necrotic changes were observed histologically as well as electron microscopically. The outer layer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc20cff82f102ffb7885c7bb282b3979
https://pubmed.ncbi.nlm.nih.gov/9811230

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