Zobrazeno 1 - 10
of 10
pro vyhledávání: '"J. Brian Morgan"'
Autor:
J. Brian Morgan, Yang Liu, Veena Coothankandaswamy, Fakhri Mahdi, Mika B. Jekabsons, William H. Gerwick, Frederick A. Valeriote, Yu-Dong Zhou, Dale G. Nagle
Publikováno v:
Marine Drugs, Vol 13, Iss 3, Pp 1552-1568 (2015)
The biologically active lipopeptide kalkitoxin was previously isolated from the marine cyanobacterium Moorea producens (Lyngbya majuscula). Kalkitoxin exhibited N-methyl-d-aspartate (NMDA)-mediated neurotoxicity and acted as an inhibitory ligand for
Externí odkaz:
https://doaj.org/article/81c9cdfe74804be6b9ba6bfe82baaec1
Autor:
Arthur E. Jacobson, J. Brian Morgan, Thomas C. Irvin, Gary R. Matyas, Zoltan Beck, Kenner C. Rice, Rodell C. Barrientos, Oscar B. Torres, Eugene S. Gutman
Publikováno v:
Rsc Chemical Biology
Active immunization is being explored as a potential therapeutic to combat accidental overdose and to mitigate the abuse potential of opioids. Hapten design is one of the crucial factors that determines the efficacy of a candidate vaccine to substanc
Autor:
Wenlong Liu, Ameeta K. Agarwal, Dale G Nagle, J. Brian Morgan, Yang Liu, Fakhri Mahdi, Yu-Dong Zhou, Mika B. Jekabsons
Publikováno v:
Journal of Natural Products. 78:3018-3023
The cananga tree alkaloid sampangine (1) has been extensively investigated for its antimicrobial and antitumor potential. Mechanistic studies have linked its biological activities to the reduction of cellular oxygen, the induction of reactive oxygen
Autor:
Veena Coothankandaswamy, Fakhri Mahdi, Koneni V. Sashidhara, Yu-Dong Zhou, Dale G. Nagle, Phillip Crews, J. Brian Morgan, Mika B. Jekabsons, Tyler A. Johnson, Yang Liu
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:5988-5994
A natural product chemistry-based approach was applied to discover small-molecule inhibitors of hypoxia-inducible factor-1 (HIF-1). A Petrosaspongia mycofijiensis marine sponge extract yielded mycothiazole (1), a solid tumor selective compound with n
Autor:
Yang Liu, Fakhri Mahdi, Veena Coothankandaswamy, Yu-Dong Zhou, J. Brian Morgan, Shui-Chun Mao, Dale G. Nagle, Mika B. Jekabsons
Publikováno v:
Journal of Natural Products. 73:956-961
Products that contain twig extracts of pawpaw (Asimina triloba, Annonaceae) are widely consumed anticancer alternative medicines. Pawpaw crude extract (CE) and purified acetogenins inhibited hypoxia-inducible factor-1 (HIF-1)-mediated hypoxic signali
Autor:
Mika B. Jekabsons, J. Brian Morgan, Fakhri Mahdi, Veena Coothankandaswamy, Yu-Dong Zhou, Yang Liu, Rui Liu, Dale G. Nagle
Publikováno v:
Journal of Natural Products. 72:2104-2109
The transcription factor hypoxia-inducible factor-1 (HIF-1) represents an important molecular target for anticancer drug discovery. In a T47D cell-based reporter assay, the Caulerpa spp. algal pigment caulerpin (1) inhibited hypoxia-induced as well a
Publikováno v:
Journal of Natural Products. 72:1927-1936
The lipid extract of the marine sponge Mycale sp. inhibited the activation of hypoxia-inducible factor-1 (HIF-1) in a human breast tumor T47D cell-based reporter assay. Bioassay-guided isolation and structure elucidation yielded 18 new lipophilic 2,5
Autor:
Kaleem A. Mohammed, Yu-Dong Zhou, Yang Liu, Mika B. Jekabsons, Coothan K. Veena, J. Brian Morgan, Dale G. Nagle
Publikováno v:
Journal of Biological Chemistry. 284:5859-5868
Hypoxia is a common feature of solid tumors, and the extent of tumor hypoxia correlates with advanced disease stages and treatment resistance. The transcription factor hypoxia-inducible factor-1 (HIF-1) represents an important tumor-selective molecul
Autor:
Mika B. Jekabsons, Yu-Dong Zhou, Dale G. Nagle, J. Brian Morgan, Yang Liu, Rui Liu, Shui-Chun Mao
Publikováno v:
Journal of Natural Products. 71:1854-1860
A natural product chemistry-based approach was employed to discover small-molecule inhibitors of the important tumor-selective molecular target hypoxia-inducible factor-1 (HIF-1). Bioassay-guided isolation of an active lipid extract of a Saipan colle
Autor:
Veena Coothankandaswamy, Fakhri Mahdi, J. Brian Morgan, Yu-Dong Zhou, Mika B. Jekabsons, Frederick A. Valeriote, Yang Liu, William H. Gerwick, Dale G. Nagle
Publikováno v:
Marine drugs, vol 13, iss 3
Marine Drugs
Volume 13
Issue 3
Pages: 1552-1568
Marine Drugs, Vol 13, Iss 3, Pp 1552-1568 (2015)
Marine Drugs
Volume 13
Issue 3
Pages: 1552-1568
Marine Drugs, Vol 13, Iss 3, Pp 1552-1568 (2015)
The biologically active lipopeptide kalkitoxin was previously isolated from the marine cyanobacterium Moorea producens (Lyngbya majuscula). Kalkitoxin exhibited N-methyl-d-aspartate (NMDA)-mediated neurotoxicity and acted as an inhibitory ligand for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ed7f23cf931b70265f5bce1644d705
https://escholarship.org/uc/item/8d0624nk
https://escholarship.org/uc/item/8d0624nk