Zobrazeno 1 - 9
of 9
pro vyhledávání: '"J. Brian McAlvin"'
Autor:
Katherine R. Peeler, Alan A. Nguyen, Maria Trissal, Jordan E Roberts, J. Brian McAlvin, Gabriella S Lamb, Deirdre Puccetti
Publikováno v:
Clinical Pediatrics. 60:205-209
Autor:
C. James Watson, Daniel L. Overbeek, Gabriella Allegri-Machado, Mark D. Kellogg, Al Patterson, J. Brian McAlvin, Michele M. Burns
Publikováno v:
Clinical toxicology (Philadelphia, Pa.). 60(7)
Publikováno v:
Anesthesia & Analgesia. 124:1804-1812
Chemical permeation enhancers (CPEs) have the potential to improve nerve blockade by site 1 sodium channel blockers such as tetrodotoxin (TTX). Here, we investigated the efficacy and toxicity of CPE-enhanced nerve blockade across a range of TTX conce
Publikováno v:
Biomaterials
Eye drops producing long-acting ocular anesthesia would be desirable for corneal pain management. Here we present liposome-based formulations to achieve very long ocular anesthetic effect after a single eye drop instillation. The liposomes were funct
Autor:
Minh T Nguyen, Krithika Ramchander, Nikolay V. Vasilyev, Morgan Moroi, J. Brian McAlvin, Alexander M Lieber, Jason Yang, Andre Shomorony, Rohit Karnik, Obiajulu S. Okonkwo, Ryan G. Wylie, Charles K. Lok, Patrick A. Armstrong, Daniel S. Kohane
Publikováno v:
JCI insight. 3(13)
Cytokines play an important role in dysregulated immune responses to infection, pancreatitis, ischemia/reperfusion injury, burns, hemorrhage, cardiopulmonary bypass, trauma, and many other diseases. Moreover, the imbalance between inflammatory and an
Autor:
Sahadev A. Shankarappa, Daniel S. Kohane, Jason Yang, J. Brian McAlvin, Robert F. Padera, Homer H. Chiang, Albert Kwon, Gally Reznor
Publikováno v:
Biomaterials. 35:4557-4564
Clinical translation of sustained release formulations for local anesthetics has been limited by adverse tissue reaction. Exparel™ (DepoFoam bupivacaine) is a new liposomal local anesthetic formulation whose biocompatibility near nerve tissue is no
Autor:
Obiajulu S. Okonkwo, Leyre Gomez, J. Brian McAlvin, Sahadev A. Shankarappa, Daniel S. Kohane, Angela Zhu, Jia Zhu, Cristina F. Stefanescu, Jesus Santamaria, Robert Langer, Manuel Arruebo, Brian P. Timko, Boaz Mizrahi
Publikováno v:
Proceedings of the National Academy of Sciences. 111:1349-1354
A reservoir that could be remotely triggered to release a drug would enable the patient or physician to achieve on-demand, reproducible, repeated, and tunable dosing. Such a device would allow precise adjustment of dosage to desired effect, with a co
Autor:
J. Brian McAlvin, Daniel S. Kohane
Publikováno v:
Advances in Delivery Science and Technology ISBN: 9781461494331
Acute and chronic pain are often treated with local anesthetic agents, whether by injection or topical application. “Conventional” agents (amino-ester and amino-amide local anesthetics) are limited by systemic and local toxicity as well as their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::018c6837ba21a569f4f39add611541d6
https://doi.org/10.1007/978-1-4614-9434-8_28
https://doi.org/10.1007/978-1-4614-9434-8_28
Autor:
Daniel S. Kohane, Gally Reznor, Sahadev A. Shankarappa, Cristina F. Stefanescu, J. Brian McAlvin
Background Local tissue injury from sustained-release formulations for local anesthetics can be severe. There is considerable variability in reporting of that injury. We investigated the influence of the intrinsic myotoxicity of the encapsulated loca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e139a648a0a572342c5d33bf2bf86c
https://europepmc.org/articles/PMC3606664/
https://europepmc.org/articles/PMC3606664/