Zobrazeno 1 - 10
of 265
pro vyhledávání: '"J. Brereton"'
Autor:
Joseph A. Bell, Elizabeth R. Davies, Christopher J. Brereton, Milica Vukmirovic, James J.W. Roberts, Kerry Lunn, Leanne Wickens, Franco Conforti, Robert A. Ridley, Jessica Ceccato, Lucy N. Sayer, David A. Johnston, Andres F. Vallejo, Aiman Alzetani, Sanjay Jogai, Ben G. Marshall, Aurelie Fabre, Luca Richeldi, Phillip D. Monk, Paul Skipp, Naftali Kaminski, Emily Offer, Yihua Wang, Donna E. Davies, Mark G. Jones
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101695- (2024)
Summary: Matrix stiffening by lysyl oxidase-like 2 (LOXL2)-mediated collagen cross-linking is proposed as a core feedforward mechanism that promotes fibrogenesis. Failure in clinical trials of simtuzumab (the humanized version of AB0023, a monoclonal
Externí odkaz:
https://doaj.org/article/28bf070de21f4af1b6319da757012509
Autor:
Eyjolfur Gudmundsson, An Zhao, Nesrin Mogulkoc, Frouke van Beek, Tinne Goos, Christopher J. Brereton, Marcel Veltkamp, Robert Chapman, Hendrik W. van Es, Helen Garthwaite, Bahareh Gholipour, Melissa Heightman, Arjun Nair, Katarina Pontoppidan, Recep Savas, Asia Ahmed, Marie Vermant, Omer Unat, Alex Procter, Laurens De Sadeleer, Emma Denneny, Timothy Wallis, Mark Duncan, Magali Taylor, Stijn Verleden, Sam M. Janes, Daniel C. Alexander, Athol U. Wells, Joanna Porter, Mark G. Jones, Iain Stewart, Coline H.M. van Moorsel, Wim Wuyts, Joseph Jacob
Publikováno v:
ERJ Open Research, Vol 9, Iss 2 (2023)
Background Computer quantification of baseline computed tomography (CT) radiological pleuroparenchymal fibroelastosis (PPFE) associates with mortality in idiopathic pulmonary fibrosis (IPF). We examined mortality associations of longitudinal change i
Externí odkaz:
https://doaj.org/article/5fc5df0263ac47c19e2f6c8941a02396
Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis
Autor:
Christopher J Brereton, Liudi Yao, Elizabeth R Davies, Yilu Zhou, Milica Vukmirovic, Joseph A Bell, Siyuan Wang, Robert A Ridley, Lareb SN Dean, Orestis G Andriotis, Franco Conforti, Lennart Brewitz, Soran Mohammed, Timothy Wallis, Ali Tavassoli, Rob M Ewing, Aiman Alzetani, Benjamin G Marshall, Sophie V Fletcher, Philipp J Thurner, Aurelie Fabre, Naftali Kaminski, Luca Richeldi, Atul Bhaskar, Christopher J Schofield, Matthew Loxham, Donna E Davies, Yihua Wang, Mark G Jones
Publikováno v:
eLife, Vol 11 (2022)
Extracellular matrix (ECM) stiffening with downstream activation of mechanosensitive pathways is strongly implicated in fibrosis. We previously reported that altered collagen nanoarchitecture is a key determinant of pathogenetic ECM structure-functio
Externí odkaz:
https://doaj.org/article/c0c5b337cbd6410caef8f61e40897d8b
Autor:
Eyjolfur Gudmundsson, An Zhao, Nesrin Mogulkoc, Iain Stewart, Mark G. Jones, Coline H.M. Van Moorsel, Recep Savas, Christopher J. Brereton, Hendrik W. Van Es, Omer Unat, Katarina Pontoppidan, Frouke Van Beek, Marcel Veltkamp, Bahareh Gholipour, Arjun Nair, Athol U. Wells, Sam M. Janes, Daniel C. Alexander, Joseph Jacob
Publikováno v:
EClinicalMedicine, Vol 38, Iss , Pp 101009- (2021)
Background: Idiopathic pulmonary fibrosis (IPF) and pleuroparenchymal fibroelastosis (PPFE) are known to have poor outcomes but detailed examinations of prognostic significance of an association between these morphologic processes are lacking. Method
Externí odkaz:
https://doaj.org/article/0adf401fc86f4683bd4a4ef3183d2393
Autor:
An Zhao, Eyjolfur Gudmundsson, Nesrin Mogulkoc, Mark G. Jones, Coline van Moorsel, Tamera J. Corte, Chiara Romei, Recep Savas, Christopher J. Brereton, Hendrik W. van Es, Helen Jo, Annalisa De Liperi, Omer Unat, Katarina Pontoppidan, Frouke van Beek, Marcel Veltkamp, Peter Hopkins, Yuben Moodley, Alessandro Taliani, Laura Tavanti, Bahareh Gholipour, Arjun Nair, Sam Janes, Iain Stewart, David Barber, Daniel C. Alexander, Athol U. Wells, Joseph Jacob
Publikováno v:
ERJ Open Research, Vol 7, Iss 3 (2021)
Externí odkaz:
https://doaj.org/article/5fc8a067bf734c7092265fdf13bf4748
Autor:
Christopher J. Brereton, Helen E. Jo
Publikováno v:
Breathe, Vol 16, Iss 3 (2020)
An acute exacerbation of idiopathic pulmonary fibrosis (AEIPF) is a potentially fatal complication of an already debilitating disease. Management is currently centred on delivering excellent supportive care and identifying reversible triggers. Despit
Externí odkaz:
https://doaj.org/article/b0f3ddb55aea4991809d06011739adeb
Autor:
Christopher J. Brereton, Timothy Wallis, Michelle Casey, Lynn Fox, Katarina Pontopiddan, Diane Laws, Jennifer Graves, Vanessa Titmuss, Sarah Kearney, Sian Evans, Alison Grove, Samreen Hamid, Luca Richeldi, Katherine M.A. O'Reilly, Sophie V. Fletcher, Mark G. Jones
Publikováno v:
ERJ Open Research, Vol 6, Iss 2 (2020)
Externí odkaz:
https://doaj.org/article/739a510a8dcc40b987da7ec15fb2d02a
Publikováno v:
Internal Medicine Journal.
Autor:
An Zhao, Eyjolfur Gudmundsson, Nesrin Mogulkoc, Coline van Moorsel, Tamera J. Corte, Chiara Romei, Robert Chapman, Tim J.M. Wallis, Emma Denneny, Tinne Goos, Recep Savas, Asia Ahmed, Christopher J. Brereton, Hendrik W. van Es, Helen Jo, Annalisa De Liperi, Mark Duncan, Katarina Pontoppidan, Laurens J. De Sadeleer, Frouke van Beek, Joseph Barnett, Gary Cross, Alex Procter, Marcel Veltkamp, Peter Hopkins, Yuben Moodley, Alessandro Taliani, Magali Taylor, Stijn Verleden, Laura Tavanti, Marie Vermant, Arjun Nair, Iain Stewart, Sam M. Janes, Alexandra L. Young, David Barber, Daniel C. Alexander, Joanna C. Porter, Athol U. Wells, Mark G. Jones, Wim A. Wuyts, Joseph Jacob
BackgroundIdiopathic pulmonary fibrosis (IPF) with co-existent emphysema, termed combined pulmonary fibrosis and emphysema (CPFE) may be associated with reduced FVC decline compared to non-CPFE IPF patients. We examined associations between mortality
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e847c368680bf7fc13e095db02bd2fa0
https://doi.org/10.1101/2023.05.05.23289330
https://doi.org/10.1101/2023.05.05.23289330
Autor:
Sophie V. Fletcher, Mark G. Jones, Elizabeth A. Renzoni, Helen Parfrey, Rachel K. Hoyles, Katherine Spinks, Maria Kokosi, Apollinaris Kwok, Chris Warburton, Vanessa Titmuss, Muhunthan Thillai, Nicola Simler, Toby M. Maher, Christopher J. Brereton, Felix Chua, Athol U. Wells, Luca Richeldi, Lisa G. Spencer
Publikováno v:
ERJ Open Research, Vol 4, Iss 4 (2018)
Externí odkaz:
https://doaj.org/article/b982002054c04350a15a154b527fa186