Zobrazeno 1 - 10
of 178
pro vyhledávání: '"J. Brenes"'
Autor:
Alejandro J Brenes, Eva Griesser, Linda V Sinclair, Lindsay Davidson, Alan R Prescott, Francois Singh, Elizabeth KJ Hogg, Carmen Espejo-Serrano, Hao Jiang, Harunori Yoshikawa, Melpomeni Platani, Jason R Swedlow, Greg M Findlay, Doreen A Cantrell, Angus I Lamond
Publikováno v:
eLife, Vol 13 (2024)
Human induced pluripotent stem cells (hiPSCs) have great potential to be used as alternatives to embryonic stem cells (hESCs) in regenerative medicine and disease modelling. In this study, we characterise the proteomes of multiple hiPSC and hESC line
Externí odkaz:
https://doaj.org/article/a4ed042a121f45aca7b7b1fad3c2840c
Autor:
Amy F. Lloyd, Anna Martinez-Muriana, Emma Davis, Michael J.D. Daniels, Pengfei Hou, Renzo Mancuso, Alejandro J. Brenes, Linda V. Sinclair, Ivana Geric, An Snellinx, Katleen Craessaerts, Tom Theys, Mark Fiers, Bart De Strooper, Andrew J.M. Howden
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114908- (2024)
Summary: Using high-resolution quantitative mass spectrometry, we present comprehensive human and mouse microglia proteomic datasets consisting of over 11,000 proteins across six microglia groups. Microglia share a core protein signature of over 5,60
Externí odkaz:
https://doaj.org/article/e4a0bd6c6fa54d609d31ad18cedf3bf0
Autor:
Gabriel Sollberger, Alejandro J. Brenes, Jordan Warner, J. Simon C. Arthur, Andrew J. M. Howden
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Neutrophils are one of the first responders to infection and are a key component of the innate immune system through their ability to phagocytose and kill invading pathogens, secrete antimicrobial molecules and produce extracellular traps. N
Externí odkaz:
https://doaj.org/article/e15085bf9185431bb8635a4710936fd7
Autor:
Christa P. Baker, Iain R. Phair, Alejandro J. Brenes, Abdelmadjid Atrih, Dylan G. Ryan, Roland Bruderer, Albena T. Dinkova-Kostova, Douglas J. Lamont, J. Simon C. Arthur, Andrew J.M. Howden
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101725- (2022)
Summary: Here, we describe an optimized protocol to analyze murine bone-marrow-derived macrophages using label-free data-independent acquisition (DIA) proteomics. We provide a complete step-by-step protocol describing sample preparation utilizing the
Externí odkaz:
https://doaj.org/article/55dbb36cd7934934bcf60bd53c5f3bf4
Autor:
Antonio Alcaraz, Alfredo Rodríguez-Antolín, Joaquín Carballido-Rodríguez, David Castro-Díaz, José Medina-Polo, Jesús M. Fernández-Gómez, Vincenzo Ficarra, Joan Palou, Javier Ponce de León Roca, Javier C. Angulo, Manuel Esteban-Fuertes, José M. Cózar-Olmo, Noemí Pérez-León, José M. Molero-García, Antonio Fernández-Pro Ledesma, Francisco J. Brenes-Bermúdez, José Manasanch
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract In a subset analysis of data from a 6-month, multicenter, non-interventional study, we compared change in symptoms and quality of life (QoL), and treatment tolerability, in men with moderate to severe lower urinary tract symptoms associated
Externí odkaz:
https://doaj.org/article/dbfb0dfd6b60488a9466f0e9d3128226
Autor:
Dylan G. Ryan, Elena V. Knatko, Alva M. Casey, Jens L. Hukelmann, Sharadha Dayalan Naidu, Alejandro J. Brenes, Thanapon Ekkunagul, Christa Baker, Maureen Higgins, Laura Tronci, Efterpi Nikitopolou, Tadashi Honda, Richard C. Hartley, Luke A.J. O’Neill, Christian Frezza, Angus I. Lamond, Andrey Y. Abramov, J. Simon C. Arthur, Doreen A. Cantrell, Michael P. Murphy, Albena T. Dinkova-Kostova
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103827- (2022)
Summary: To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its negative regulator, Kelch-like ECH associated protein
Externí odkaz:
https://doaj.org/article/59b0d8bd2ed646e68bc099da31cf94d0
Autor:
Alejandro J Brenes, Maud Vandereyken, Olivia J James, Harriet Watt, Jens Hukelmann, Laura Spinelli, Dina Dikovskaya, Angus I Lamond, Mahima Swamy
Publikováno v:
eLife, Vol 10 (2021)
Tissue-resident intestinal intraepithelial T lymphocytes (T-IEL) patrol the gut and have important roles in regulating intestinal homeostasis. T-IEL include both induced T-IEL, derived from systemic antigen-experienced lymphocytes, and natural T-IEL,
Externí odkaz:
https://doaj.org/article/6e624ebedfb24dd29e8cecd5bdc4e781
Autor:
Leila Reyes, Manuel A. Sanchez-Garcia, Tyler Morrison, Andy J. M. Howden, Emily R. Watts, Simone Arienti, Pranvera Sadiku, Patricia Coelho, Ananda S. Mirchandani, Ailiang Zhang, David Hope, Sarah K. Clark, Jo Singleton, Shonna Johnston, Robert Grecian, Azin Poon, Sarah McNamara, Isla Harper, Max Head Fourman, Alejandro J. Brenes, Shalini Pathak, Amy Lloyd, Giovanny Rodriguez Blanco, Alex von Kriegsheim, Bart Ghesquiere, Wesley Vermaelen, Camila T. Cologna, Kevin Dhaliwal, Nik Hirani, David H. Dockrell, Moira K. B. Whyte, David Griffith, Doreen A. Cantrell, Sarah R. Walmsley
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus disease 2019 (COVID-19). Neutrophils play a key ro
Externí odkaz:
https://doaj.org/article/69dfb1e9146244cb9d8db5194cef99af
Autor:
Leila Reyes, Manuel A. Sanchez-Garcia, Tyler Morrison, Andy J. M. Howden, Emily R. Watts, Simone Arienti, Pranvera Sadiku, Patricia Coelho, Ananda S. Mirchandani, Ailiang Zhang, David Hope, Sarah K. Clark, Jo Singleton, Shonna Johnston, Robert Grecian, Azin Poon, Sarah McNamara, Isla Harper, Max Head Fourman, Alejandro J. Brenes, Shalini Pathak, Amy Lloyd, Giovanny Rodriguez Blanco, Alex von Kriegsheim, Bart Ghesquiere, Wesley Vermaelen, Camila T. Cologna, Kevin Dhaliwal, Nik Hirani, David H. Dockrell, Moira K. B. Whyte, David Griffith, Doreen A. Cantrell, Sarah R. Walmsley
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus disease 2019 (COVID-19). Neutrophils play a key ro
Externí odkaz:
https://doaj.org/article/fdf252eb205a4660a9cdfc932717fe99
Publikováno v:
Organic Letters. 24:5109-5114
Herein, we report a modular catalytic technique that streamlines the preparation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca8e201921558566baba88e9d05ada5
https://doi.org/10.1021/acs.orglett.2c01941
https://doi.org/10.1021/acs.orglett.2c01941