Výsledky vyhledávání - "J. Breithaupt"

Akademický článek

PCSK9 activation promotes early atherosclerosis in a vascular microphysiological system

Autor: Jounghyun H. Lee, Kevin L. Shores, Jason J. Breithaupt, Caleb S. Lee, Daniella M. Fodera, Jennifer B. Kwon, Adarsh R. Ettyreddy, Kristin M. Myers, Benny J. Evison, Alexandra K. Suchowerska, Charles A. Gersbach, Kam W. Leong, George A. Truskey

Publikováno v: APL Bioengineering, Vol 7, Iss 4, Pp 046103-046103-15 (2023)

Atherosclerosis is a primary precursor of cardiovascular disease (CVD), the leading cause of death worldwide. While proprotein convertase subtilisin/kexin 9 (PCSK9) contributes to CVD by degrading low-density lipoprotein receptors (LDLR) and altering

Externí odkaz: https://doaj.org/article/f6d0b5cc6b244d04bac23d3123f01c78

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Akademický článek

Modeling early stage atherosclerosis in a primary human vascular microphysiological system

Autor: Xu Zhang, Muath Bishawi, Ge Zhang, Varun Prasad, Ellen Salmon, Jason J. Breithaupt, Qiao Zhang, George A. Truskey

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

Human microphysiological systems (MPS) have some advantages over animal models to study the mechanisms of disease. Here the authors use a tissue-engineered blood vessel MPS to create a model of early stage atherosclerosis and assess the effect of sev

Externí odkaz: https://doaj.org/article/8d57cac5f23b4a1ca7ed71c83c025052

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Akademický článek

Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation

Autor: Ellen E. Salmon, Jason J. Breithaupt, George A. Truskey

Publikováno v: Cells, Vol 9, Iss 5, p 1292 (2020)

Clinical studies have established a connection between oxidative stress, aging, and atherogenesis. These factors contribute to senescence and inflammation in the endothelium and significant reductions in endothelium-dependent vasoreactivity in aged p

Externí odkaz: https://doaj.org/article/fd807292b7d343319c6719501390f0e8

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Modeling early stage atherosclerosis in a primary human vascular microphysiological system

Autor: Jason J. Breithaupt, Muath Bishawi, Ellen Salmon, Ge Zhang, Qiao Zhang, George A. Truskey, Xu Zhang, Varun Prasad

Publikováno v: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

Novel atherosclerosis models are needed to guide clinical therapy. Here, we report an in vitro model of early atherosclerosis by fabricating and perfusing multi-layer arteriole-scale human tissue-engineered blood vessels (TEBVs) by plastic compressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79b4c7ce0938eba67bfae1a30c1665c
http://europepmc.org/articles/PMC7591486

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First Report of 'Candidatus Liberibacter asiaticus' Associated with Huanglongbing in Sweet Orange in Ethiopia

Autor: G. De Bac, L. Catalano, J. Breithaupt, R. K. Yokomi, Maria Saponari, Giuliana Loconsole

Publikováno v: Plant disease 94 (2010): 482–482. doi:10.1094/PDIS-94-4-0482A
info:cnr-pdr/source/autori:M. Saponari; G. De Bac; J. Breithaupt; G. Loconsole; R. K. Yokomi; L. Catalano/titolo:First Report of 'Candidatus Liberibacter asiaticus' Associated with Huanglongbing in Sweet Orange in Ethiopia/doi:10.1094%2FPDIS-94-4-0482A/rivista:Plant disease/anno:2010/pagina_da:482/pagina_a:482/intervallo_pagine:482–482/volume:94

Huanglongbing (HLB) is a serious disease of citrus worldwide. Three different ‘Candidatus Liberibacter’ species are associated with HLB: ‘Ca. Liberibacter asiaticus’, ‘Ca. L. africanus’, and ‘Ca. L. americanus’ (1). ‘Ca. L. africanu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e771bf9cae9935fd5246d80dd9f08e
https://pubmed.ncbi.nlm.nih.gov/30754508

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Effects of myosin light chain phosphorylation on length-dependent myosin kinetics in skinned rat myocardium

Autor: Jason J. Breithaupt, Bertrand C.W. Tanner, Peter O. Awinda, Hannah C. Pulcastro

Publikováno v: Archives of Biochemistry and Biophysics. 601:56-68

Myosin force production is Ca(2+)-regulated by thin-filament proteins and sarcomere length, which together determine the number of cross-bridge interactions throughout a heartbeat. Ventricular myosin regulatory light chain-2 (RLC) binds to the neck o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54dafc466e06b821cc3b18cc88944b82
https://doi.org/10.1016/j.abb.2015.12.014

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Myosin MgADP release rate decreases at longer sarcomere length to prolong myosin attachment time in skinned rat myocardium

Autor: Jason J. Breithaupt, Bertrand C.W. Tanner, Peter O. Awinda

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 309:H2087-H2097

Cardiac contractility increases as sarcomere length increases, suggesting that intrinsic molecular mechanisms underlie the Frank-Starling relationship to confer increased cardiac output with greater ventricular filling. The capacity of myosin to bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100c9a830c8f359d45a679aaa447d0d9
https://doi.org/10.1152/ajpheart.00555.2015

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