Zobrazeno 1 - 10
of 123
pro vyhledávání: '"J. Brackenbury"'
Autor:
Otso Arponen, Mary A. McLean, Muzna Nanaa, Roido Manavaki, Gabrielle C. Baxter, Andrew B. Gill, Frank Riemer, Aneurin J. Kennerley, Ramona Woitek, Joshua D. Kaggie, William J. Brackenbury, Fiona J. Gilbert
Publikováno v:
European Radiology Experimental, Vol 8, Iss 1, Pp 1-12 (2024)
Abstract Background To study the reproducibility of 23Na magnetic resonance imaging (MRI) measurements from breast tissue in healthy volunteers. Methods Using a dual-tuned bilateral 23Na/1H breast coil at 3-T MRI, high-resolution 23Na MRI three-dimen
Externí odkaz:
https://doaj.org/article/7d1674cb5ff3460396829bde23960db3
Autor:
Alina L. Capatina, Jodie R. Malcolm, Jack Stenning, Rachael L. Moore, Katherine S. Bridge, William J. Brackenbury, Andrew N. Holding
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The events that control breast cancer progression and metastasis are complex and intertwined. Hypoxia plays a key role both in oncogenic transformation and in fueling the metastatic potential of breast cancer cells. Here we review the impact of hypox
Externí odkaz:
https://doaj.org/article/f6a8d132a2184bfd98fff60b790f10b2
Autor:
William J. Brackenbury, Carlo Palmieri
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-3 (2023)
Abstract The development of therapies that can suppress invasion and prevent metastasis, ‘anti-metastatic drugs’, is an important area of unmet therapeutic need. The new results of a recent open-label, multicentre randomised trial published in J
Externí odkaz:
https://doaj.org/article/5ca835b4162e4dd3927fd9caa281f9d4
Autor:
Laura Wiggins, Alice Lord, Killian L. Murphy, Stuart E. Lacy, Peter J. O’Toole, William J. Brackenbury, Julie Wilson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Approaches for temporal analysis and quantitative characterisation of single cell morphology and dynamics remain in high demand. Here authors present CellPhe, a pattern recognition toolkit for the unbiased characterisation of cellular phenotypes with
Externí odkaz:
https://doaj.org/article/e14ee54bcba749f18c7ebd636fb74fbf
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Hypoxia in disease describes persistent low oxygen conditions, observed in a range of pathologies, including cancer. In the discovery of biomarkers in biological models, pathophysiological traits present a source of translatable metabolic products fo
Externí odkaz:
https://doaj.org/article/b112b61837b34f80a6d4884867a1f1fa
Autor:
Andrew D. James, Katherine P. Unthank, Isobel Jones, Nattanan Sajjaboontawee, Rebecca E. Sizer, Sangeeta Chawla, Gareth J. O. Evans, William J. Brackenbury
Publikováno v:
Physiological Reports, Vol 11, Iss 7, Pp n/a-n/a (2023)
Abstract Intracellular Ca2+ signaling and Na+ homeostasis are inextricably linked via ion channels and co‐transporters, with alterations in the concentration of one ion having profound effects on the other. Evidence indicates that intracellular Na+
Externí odkaz:
https://doaj.org/article/bb26b4acd581462d9729855e5f1d9389
Publikováno v:
BMJ Open, Vol 13, Iss 2 (2023)
Objectives Antiepileptic and antiarrhythmic drugs inhibit voltage-gated sodium (Na+) channels (VGSCs), and preclinical studies show that these medications reduce tumour growth, invasion and metastasis. We investigated the association between VGSC inh
Externí odkaz:
https://doaj.org/article/db9a925477d44a53be4767474335a176
Autor:
Anna Simon, Ming Yang, Joanne L. Marrison, Andrew D. James, Mark J. Hunt, Peter J. O’Toole, Paul M. Kaye, Miles A. Whittington, Sangeeta Chawla, William J. Brackenbury
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Abstract Background An emerging problem in the treatment of breast cancer is the increasing incidence of metastases to the brain. Metastatic brain tumours are incurable and can cause epileptic seizures and cognitive impairment, so better understandin
Externí odkaz:
https://doaj.org/article/83744fe99058415e8571e6153d33ff04
Autor:
Osbaldo Lopez-Charcas, Piyasuda Pukkanasut, Sadanandan E. Velu, William J. Brackenbury, Tim G. Hales, Pierre Besson, Juan Carlos Gomora, Sébastien Roger
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102270- (2021)
Summary: Voltage-gated sodium (NaV) channels, initially characterized in excitable cells, have been shown to be aberrantly expressed in non-excitable cancer tissues and cells from epithelial origins such as in breast, lung, prostate, colon, and cervi
Externí odkaz:
https://doaj.org/article/552553f08746459d99992c944ee30620
Publikováno v:
Metabolites, Vol 12, Iss 7, p 599 (2022)
Volatile compounds, abundant in breath, can be used to accurately diagnose and monitor a range of medical conditions. This offers a noninvasive, low-cost approach with screening applications; however, the uptake of this diagnostic approach has been l
Externí odkaz:
https://doaj.org/article/08055b1756bb437887b9c23237473993