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Biocompatibility of Cellulosic and Synthetic Membranes Assessed by Leukocyte Activation

Autor: Antonio Ordinas, Raul Tonda, Ana M. Galan, Arturo Pereira, Gines Escolar, Aleix Cases, J. Bozzo, Maria Rosa Hernandez, José Lopez-Pedret

Publikováno v: American Journal of Nephrology. 24:235-241

Background/Aims: The contact of blood with artificial surfaces may activate blood leukocytes and platelets and initiate the leukocyte inflammatory response. We have investigated the effect of a hemodialysis (HD) with a cellulosic- and a synthetic-bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8614fddfb57a4bf822afae44100588
https://doi.org/10.1159/000077395

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Concentrates containing factor IX could improve haemostasis under conditions of thrombocytopenia: studies in an in vitro model

Autor: A M Galan, M. R. Hernández, J. Aznar-Salatti, Juan Carlos Reverter, Gines Escolar, J. Bozzo, M. Pino, Antonio Ordinas, M Vinas

Publikováno v: Vox Sanguinis. 82:113-118

Background and Objectives We explored the effect on haemostasis of different factor IX (FIX) concentrates under thrombocytopenic conditions using an in vitro perfusion technique. Materials and Methods A moderate experimental thrombocytopenia (25 000�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e848b26e6837221c590a4d4d8b45e27
https://doi.org/10.1046/j.1423-0410.2002.00157.x

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Prohemorrhagic Potential of Dipyrone, Ibuprofen, Ketorolac, and Aspirin: Mechanisms Associated with Blood Flow and Erythrocyte Deformability

Autor: Antonio Ordinas, A M Galan, J. Bozzo, Gines Escolar, M. R. Hernández

Publikováno v: Journal of Cardiovascular Pharmacology. 38:183-190

Dipyrone, ibuprofen, ketorolac, and aspirin were tested in a well-defined perfusion system (shear rates: 300/s, 800/s, and 1,800/s). Whole blood samples were treated with the drugs at analgesic doses and platelet interaction with damaged subendotheli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9c0087915aff6f12270576d07bc3a2
https://doi.org/10.1097/00005344-200108000-00003

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Infusible platelet membranes improve hemostasis in thrombocytopenic blood: experimental studies under flow conditions

Autor: Marcos Pino, Antonio Ordinas, Gines Escolar, Juan‐Carlos Reverter, J. Bozzo, Roberto Mazzara, A M Galan, M. R. Hernández

Publikováno v: Transfusion. 40:1074-1080

BACKGROUND The potential hemostatic effect of infusible platelet membranes (IPM; Cyplex, Cypress Bioscience) prepared from outdated human platelets is investigated. STUDY DESIGN AND METHODS Increasing concentrations of IPM were added to blood samples

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afbecb775a8da58e092c5978885a2d56
https://doi.org/10.1046/j.1537-2995.2000.40091074.x

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A monoclonal antibody to leukocyte integrin CD11b inhibits leukocyte and platelet activation induced by shear stress

Autor: Gines Escolar, M. R. Hernández, J. Bozzo, Dolors Tàssies, Antonio Ordinas

Publikováno v: InflammoPharmacology. 8:149-159

Leukocyte-platelet interactions are mediated by cellular antigens and result in cellular activation and formation of aggregates composed of leukocytes and platelets. Rheological mechanisms play a key role in cellular activation phenomena. We have inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1746338d90c55c837c8d8db6d38d0a6a
https://doi.org/10.1163/15685600038170

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Antiplatelet Effects of Sodium Nitroprusside in Flowing Human Blood

Autor: Ana M. Galan, J. Bozzo, Antonio Ordinas, Magda Heras, Maria Rosa Hernandez, Gines Escolar

Publikováno v: Thrombosis Research. 97:217-225

We explored the ability of sodium nitroprusside to modify adhesive and cohesive function of platelets in flowing blood, under normoxic and hypoxic conditions. Aliquots of both untreated and sodium nitroprusside–treated blood were prepared for studi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::626a36141f856594e9a578196155059d
https://doi.org/10.1016/s0049-3848(99)00154-1

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Assessment of Potential Thrombogenicity of Coagulation Factor IX Concentrates in an in Vitro Model of Human Thrombogenesis

Autor: Gines Escolar, M. Rosa Hernandez, J. Bozzo, Juan Carlos Reverter, Ana M. Galan, J Aznar-Salatti

Publikováno v: Thrombosis Research. 96:383-389

We have investigated the potential use of perfusion techniques in the evaluation of the thrombogenic profile of factor IX concentrates. Blood from healthy donors was anticoagulated with low molecular weight heparin and incubated with one of the follo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18adec8725bd46d414493f16db8da91
https://doi.org/10.1016/s0049-3848(99)00134-6

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Impaired antiplatelet effects of aspirin associated with hypoxia and ATP release from erythrocytes. Studies in a system with flowing human blood

Autor: Antonio Ordinas, A M Galan, Magda Heras, Gines Escolar, J. Bozzo, M. R. Hernández

Publikováno v: European Journal of Clinical Investigation. 29:438-444

Background We have explored how hypoxic conditions may affect the antiplatelet effects of aspirin. Materials and methods For this purpose, a perfusion system containing a damaged vessel segment was modified in order to induce hypoxia (low Po2) in flo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e37f5809649795e4921aeeaada7a110e
https://doi.org/10.1046/j.1365-2362.1999.00483.x

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