Zobrazeno 1 - 10
of 29
pro vyhledávání: '"J. Bondo Hansen"'
Publikováno v:
Current Medicinal Chemistry. 11:1595-1615
The pattern of insulin release is crucial for regulation of glucose and lipid haemostasis. Deficient insulin release causes hyperglycemia and diabetes, whereas excessive insulin release can give rise to serious metabolic disorders, such as nesidiobla
Autor:
Ming Li, James T. Taylor, Brian Keyser, Min Zhang, Luping Huang, J. Bondo Hansen, Hean Zhuang, David S. Ragsdale, Tina Møller Tagmose
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 309:193-199
Mibefradil is a Ca2+ channel antagonist that inhibits both T-type and high-voltage-activated Ca2+ channels. We previously showed that block of high-voltage-activated channels by mibefradil occurs through the production of an active metabolite by intr
Publikováno v:
Diabetologia. 46:80-88
We aimed to study the effects of two K(ATP) channel openers (KCO), diazoxide and the more potent compound NNC 55-0118, on beta-cell suppression and/or toxicity induced by alloxan, sodium nitroprusside and IL-1beta.Islets from rats were exposed to 0.3
Autor:
Lone Pridal, Finn Junager, Nils Dragsted, Anette Koch, J. Bondo Hansen, Svend Treppendahl, John Patrick Mogensen, Lars Ynddal, Anne Worsaae, Tina Møller Tagmose, Harrie C. M. Boonen, Per Arkhammar, Peter Mackay, Carsten Enggaard Stidsen, Philip Wahl, Thora B. Bodvarsdottir, Flemming Elmelund Nielsen
Publikováno v:
Journal of Medicinal Chemistry. 45:4171-4187
6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives were synthesized and characterized as activators of adenosine 5'-triphosphate (ATP) sensitive potassium (K(ATP)) channels in the beta-cells by measuring effects on membr
Autor:
Per Arkhammar, J. Bondo Hansen, Philippe Lebrun, Q.-A. Nguyen, M.-H. Antoine, Bernard Pirotte
Publikováno v:
Diabetologia. 43:723-732
Aims/hypothesis. To characterise the effects of BPDZ 73 (7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide), a newly synthesised diazoxide analogue, on insulin secretory cells.¶Methods. Measurements of 86Rb, 45Ca outflow, membrane pote
Autor:
J. Bondo Hansen, Anders Fink-Jensen, Mark A. Scheideler, Louis Brammer Hansen, Erik B. Nielsen
Publikováno v:
European Journal of Medicinal Chemistry. 32:103-111
Summary A series of potential antipsychotic compounds have been synthesized by combining a furocoumarin heterocycle through a linker of different sizes with an arylpiperazine or piperidine moiety. Several of the compounds show very high affinity for
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:695-698
The synthesis of 3-carboxamide and 3-carboxylates of pyrazolo[1,5-a]pyridines and pyrazolo[1,5-b]pyridazines is described. These compounds are characterized as potent and selective 5HT3-antagonists in vitro and in vivo.
Publikováno v:
ChemInform. 29
Autor:
J. Bondo Hansen, Tina Møller Tagmose, Anne Worsaae, Philip Wahl, John Patrick Mogensen, Pia C. Agerholm, Per Arkhammar
Publikováno v:
ChemInform. 32
3,5-Disubstituted-phenylcyanoguanidines have been identified as activators of SUR1/Kir6.2 potassium channels and as potent inhibitors of insulin release from pancreatic beta cells in vitro.
Autor:
Thora B. Bodvarsdottir, Lars Ynddal, Søren Ebdrup, Flemming Elmelund Nielsen, Anette Frost Jensen, Carsten Enggaard Stidsen, J. Bondo Hansen, Tinna Fremming, Anne Worsaae, Hanne T. Kornø, Per Arkhammar, Harrie C. M. Boonen, Philip Wahl
Publikováno v:
Journal of medicinal chemistry. 49(14)
Compound 1a (NN414) is a potent opener of Kir6.2/SUR1 K(ATP) channels. Compound 1a inhibits insulin release in vitro and in vivo and preserves beta cell function in preclinical animal models suggesting that such a compound could find use in treatment