Zobrazeno 1 - 10
of 230
pro vyhledávání: '"J. Bolard"'
Publikováno v:
Langmuir. 13:5634-5643
The interaction of positively charged anthracyclines, pirarubicin, and adriamycin with planar monolayers and bilayers of zwitterionic and anionic phospholipids (POPC and DPPA) is reported, by using a surface pressure technique and surface-enhanced re
Autor:
E. S. Tabosa Do Egito, Gillian Barratt, Philippe Legrand, Hatem Fessi, M. Appel, J.P. Devissaguet, J. Bolard
Publikováno v:
International Journal of Pharmaceutics. 145:17-27
The structure of an amphotericin B emulsion-based delivery system (AmB-E) was investigated using spectroscopic methods (electronic absorption and circular dichroism (CD)), photon correlation spectroscopy (PCS) and transmission electron microscopy (TE
Autor:
J Bolard, J Brajtburg
Publikováno v:
Clinical Microbiology Reviews. 9:512-531
Amphotericin B (AmB), the drug of choice for the treatment of most systemic fungal infections, is marketed under the trademark Fungizone, as an AmB-deoxycholate complex suitable for intravenous administration. The association between AmB and deoxycho
Publikováno v:
Antimicrobial Agents and Chemotherapy. 38:1079-1084
The effect of ergosterol depletion by ketoconazole on the leishmanicidal activity of the pore-forming antibiotic amphotericin B (AmB) was investigated. Leishmania mexicana promastigotes were lysed within minutes by the addition of micromolar concentr
Publikováno v:
Antimicrobial Agents and Chemotherapy. 36:1799-1804
Publikováno v:
Antimicrobial Agents and Chemotherapy. 36:262-266
We studied the influence of the lipid/amphotericin B (AMB) ratio and the phospholipid type on the in vitro renal cell toxicity and antifungal efficacy of lipid-associated AMB (L-AMB). L-AMB was prepared at one of two different lipid/AMB ratios (1 and
Publikováno v:
Antimicrobial Agents and Chemotherapy. 34:1584-1589
A comparative study of the effect of the polyene antibiotic amphotericin B (AmB) on the viability of Leishmania mexicana promastigotes before and after their transformation by heat into amastigotelike forms was carried out. The kinetics of cell death
Publikováno v:
Acta biochimica Polonica. 47(1)
Rational chemical modification of amphotericin B (AMB) led to the synthesis of sterically hindered AMB derivatives. The selected optimal compound, N-methyl-N-D-fructosyl amphotericin B methyl ester (MF-AME) retains the broad spectrum of antifungal ac
Publikováno v:
Biochimica et biophysica acta. 1464(2)
Antisense strategy requires efficient systems for the delivery of oligodeoxyribonucleotides (ODN) into target cells. Cationic amphiphiles have shown good efficiency in vitro and a lot of attention is currently paid to their interaction with nucleic a
Publikováno v:
The Journal of antimicrobial chemotherapy. 42(6)
Heat-induced 'superaggregation' of deoxycholate-amphotericin B (AmB-DOC, Fungizone) was shown previously to reduce the in-vitro toxicity of this antifungal agent. We compared AmB-DOC with the formulation obtained by heating the commercial form (Fungi