Plasmin drives burn-induced systemic inflammatory response syndrome

Autor: Breanne H. Y. Gibson, Colby C. Wollenman, Stephanie N. Moore-Lotridge, Patrick R. Keller, J. Blair Summitt, Alexey R. Revenko, Matthew J. Flick, Timothy S. Blackwell, Jonathan G. Schoenecker

Publikováno v: JCI Insight, Vol 6, Iss 23 (2021)

Severe injuries, such as burns, provoke a systemic inflammatory response syndrome (SIRS) that imposes pathology on all organs. Simultaneously, severe injury also elicits activation of the fibrinolytic protease plasmin. While the principal adverse out

Externí odkaz: https://doaj.org/article/a90615824a274fa1b72ec0924b085a18

Plastic Surgery: A Practical Guide to Operative Care

Autor: Mark S. Granick, Stephanie Suprenant, Richard Baynosa, Christopher J.M. Brooks, Jonathan Keith, Paul N. Afrooz, C. Scott Hultman, Edward A. Luce, Alexandra M. Hart, Bruce A. Mast, Jose L.M. del Yerro, James E. Zins, Cagri Cakmakoglu, Richard L. Drake, Sonu A. Jain, Zachary T. Young, Timothy W. King, John Layliev, William C. Lineaweaver, Maryann E. Martinovic, J. Blair Summitt, Galen Perdikis, Brandon K. Richland, Jeffrey A. Gusenoff, Rukmini Rednam, Mario Rueda, Richard Gregory, Patrick J. Buchanan, Noah H. Prince, Felmont F. Eaves, Andrew G. Silver, Luke Pearson, J. Peter Rubin, Ahmed M. Hashem, Andrea L. Pozez, Gregory R.D. Evans, Leonard T. Furlow, John H. Phillips, Dhruv Singhal, Manuel R. Vegas, Rachel Cohen-Shohet, R. Brad Nesmith, Brendan Alleyne, Raffi Gurunluoglu, Loretta Coady-Fariborzian, Aditya Sood, Ruston Sanchez, Lynn A. Damitz, Gregory A. Dumanian, Stephanie L. Koonce, Alan Matarasso, Paul Diegidio, Krishna S. Vyas, Nasim Abedi, Kenneth C. Shestak, Robert A. Weber, Ashley K. Lentz, Kent K. Higdon, Varun Gupta, Yee Cheng Low, Emil J. Kohan, Lisa M. Block, Michael L. Bentz, Shuhao Zhang, Steven J. Hermiz, Albert Losken, Paul A. Ghareeb, Edward H. Davidson, Daniel F. Haynes, Jorge de la Torre, Russell Walther, Steven Rueda, Steven L. Bernard, Mark M. Leyngold, A. Neil Salyapongse, Geo N. Tabbal, Julian Winocour, William J. Campbell, Michael Friel, Jessica A. Ching, Sushmita Mittal, Winston Richards, Henry C. Vasconez, Han Shi, Eliana F.R. Duraes, Adam J. Katz, Nishant Ganesh Kumar, Brian D. Rinker, Chris McCarthy, Cristiano Boneti, Lauren C. Nigro, Rachel I. Mason Weber, Francesco M. Egro, Wendy Lynne Czerwinski

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b4ee9edc1f8c95bfed7c81790d6d12e
https://doi.org/10.1055/b-006-163728

Hyperactivation of Plasmin Following Severe Burn Is Associated with Systemic Inflammation and Coagulopathy

Autor: Jonathan G. Schoenecker, Stephanie N. Moore-Lotridge, Patrick R Keller, Breanne H.Y. Gibson, J. Blair Summitt

Publikováno v: Blood. 132:3780-3780

INTRODUCTION: Severe injury provokes coagulopathy and systemic inflammatory response syndrome (SIRS) that, in concurrence, greatly increase the risk of life-threatening complications including bleeding, thrombosis, and multi-organ dysfunction syndrom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a2a3f8306d4b87ff615c2084cc4240e
https://doi.org/10.1182/blood-2018-99-116904

New Innovations for Deep Partial-Thickness Burn Treatment with ACell MatriStem Matrix

Autor: Alexander J. Kaminsky, J. Blair Summitt, Justine S. Kim, Wesley P. Thayer

Publikováno v: Advances in wound care. 5(12)

Objective: Burn injuries remain a large financial burden on the healthcare system. According to CDC statistics (2010), nonfatal and hospitalized burns in the U.S. cost $1.8 billion for an annual incidence of ∼486,000 cases. To date, no technique pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0a3c887650c6217b62abd3c2ba7f50
https://pubmed.ncbi.nlm.nih.gov/28078188