Zobrazeno 1 - 10
of 415
pro vyhledávání: '"J. Billingham"'
Publikováno v:
Royal Society Open Science, Vol 4, Iss 7 (2017)
In waterjet and laser milling, material is removed from a solid surface in a succession of layers to create a new shape, in a depth-controlled manner. The inverse problem consists of defining the control parameters, in particular, the two-dimensional
Externí odkaz:
https://doaj.org/article/4b7401f1c3b946af98da91e12a102ecc
Autor:
J Billingham, D J Needham
Publikováno v:
Nonlinearity. 35:6098-6123
We study non-negative travelling wave solutions, u ≡ U(x − ct) with constant wavespeed c > 0, of the cubic nonlocal Fisher-KPP equation in one spatial dimension, namely, ∂ u ∂ t = ∂ 2 u ∂ x 2 + u 2 1 − 1 λ ∫ − ∞ ∞ ϕ y − x λ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a02418ac33de5b63ae9a5d6c0b662aad
https://doi.org/10.1088/1361-6544/ac98ea
https://doi.org/10.1088/1361-6544/ac98ea
A hypothetical example of an updated DTP for Cohorts 4 to 6 in the Viola trial after observing 0/3 DLT at Dose 0, 1/3 DLT at Dose 1 and 0/3 DLT at Dose 1 for Cohorts 1 to 3 respectively (i.e. pathway 5 in Table 2). This table presents all 64 pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6a311f1fba250c7dbe3ed61b3a83b0
https://doi.org/10.1158/1078-0432.22461983.v1
https://doi.org/10.1158/1078-0432.22461983.v1
Original DTP for Cohorts 1 to 3 (with cohort size of 3) with all 64 pathways without stopping early for excessive toxicity in Viola. The design will always recommend staying at the lowest dose even when high numbers of DLTs are observed at the lowest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156394ff520ecab5235b2eb74bcd6cc7
https://doi.org/10.1158/1078-0432.22461986
https://doi.org/10.1158/1078-0432.22461986
The ever-increasing pace of development of novel therapies mandates efficient methodologies for assessment of their tolerability and activity. Evidence increasingly support the merits of model-based dose-finding designs in identifying the recommended
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2208128856dc3c1e06195cb93755bf
https://doi.org/10.1158/1078-0432.c.6524975.v1
https://doi.org/10.1158/1078-0432.c.6524975.v1
DTP-Heatmap of risk of lowest dose being too toxic. This figure presents a heatmap to highlight any case where there is a high chance that the lowest dose is too toxic (greater than 0.3 DLT rate) based on the accumulated data in each pathway for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bed88b1a40b7d53949a3e36532cc351
https://doi.org/10.1158/1078-0432.22461989
https://doi.org/10.1158/1078-0432.22461989
A hypothetical example of an updated DTP for Cohorts 7 to 9 in the Viola trial with the final recommended MTD. This is based on observing DLT outcomes of 0/3 DLT at Dose 0, 1/3 DLT at Dose 1 and 0/3 DLT at Dose 1 for Cohorts 1 to 3 respectively (path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598d255369c85839fe17d38eb0557e40
https://doi.org/10.1158/1078-0432.22461980.v1
https://doi.org/10.1158/1078-0432.22461980.v1
Finding and interpreting the solutions of differential equations is a central and essential part of applied mathematics. This book aims to enable the reader to develop the required skills needed for a thorough understanding of the subject. The author
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.