Zobrazeno 1 - 10
of 133
pro vyhledávání: '"J. Billing"'
Autor:
Lawrence J. Billing, Pierre Larraufie, Jo Lewis, Andrew Leiter, Joyce Li, Brian Lam, Giles SH. Yeo, Deborah A. Goldspink, Richard G. Kay, Fiona M. Gribble, Frank Reimann
Publikováno v:
Molecular Metabolism, Vol 29, Iss , Pp 158-169 (2019)
Objective: Enteroendocrine cells (EECs) of the large intestine, found scattered in the epithelial layer, are known to express different hormones, with at least partial co-expression of different hormones in the same cell. Here we aimed to categorize
Externí odkaz:
https://doaj.org/article/880adfcb0c684885b7974b0937ab2141
Autor:
Deborah A. Goldspink, Van B. Lu, Emily L. Miedzybrodzka, Christopher A. Smith, Rachel E. Foreman, Lawrence J. Billing, Richard G. Kay, Frank Reimann, Fiona M. Gribble
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107833- (2020)
Summary: Glucagon-like peptide-1 (GLP-1) from intestinal L-cells stimulates insulin secretion and reduces appetite after food ingestion, and it is the basis for drugs against type-2 diabetes and obesity. Drugs targeting L- and other enteroendocrine c
Externí odkaz:
https://doaj.org/article/afe639a516f74f0cacef5f0a9acfdb57
Autor:
Lawrence J. Billing, Christopher A. Smith, Pierre Larraufie, Deborah A. Goldspink, Sam Galvin, Richard G. Kay, Jonathan D. Howe, Ryan Walker, Mihai Pruna, Leslie Glass, Ramona Pais, Fiona M. Gribble, Frank Reimann
Publikováno v:
Molecular Metabolism, Vol 16, Iss , Pp 65-75 (2018)
Objective: Insulin-like peptide-5 (INSL5) is an orexigenic gut hormone found in a subset of colonic and rectal enteroendocrine L-cells together with the anorexigenic hormones glucagon-like peptide-1 (GLP-1) and peptideYY (PYY). Unlike GLP-1 and PYY,
Externí odkaz:
https://doaj.org/article/15266b662de9491591e17a5aadc4ad21
Autor:
Deborah A. Goldspink, Van B. Lu, Lawrence J. Billing, Pierre Larraufie, Gwen Tolhurst, Fiona M. Gribble, Frank Reimann
Publikováno v:
Molecular Metabolism, Vol 7, Iss , Pp 90-101 (2018)
Objectives: The aim of this study was to investigate the electrical properties of ileal Glucagon-like peptide 1 (GLP-1) secreting L-cells using murine organoid cultures and the electrophysiological and intracellular signaling pathways recruited follo
Externí odkaz:
https://doaj.org/article/9114eb91b75a45ea9ed8146d86524fcb
Publikováno v:
British Journal of Surgery. 109
Background Metabolic Surgery (MS) is commonly performed in a hospital setting. Same-day case (SDC) MS has not been performed due to concern for patient safety and complications after discharge. Procedures performed in ambulatory surgical centers (ASC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b87a3c3e58e1c5276a43f55e3d5ff5aa
https://doi.org/10.1093/bjs/znac402.008
https://doi.org/10.1093/bjs/znac402.008
Rationale Asthma phenotyping requires novel biomarker discovery. Objectives To identify plasma biomarkers associated with asthma phenotypes by application of a new proteomic panel to samples from two well-characterised cohorts of severe (SA) and mild
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::6f3a337b59e2317ed59ff73b6f19721b
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3100415
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3100415
Autor:
Lewis Je, Lawrence J. Billing, Bertie Gottgens, Fiona M. Gribble, Christopher A. Smith, John Tadross, Kinston Sj, Cheryl A. Brighton, David Baker, Marco Tripodi, Hornigold D, Woodward Or, Benjamin U. Phillips, Ciabatti E, Alice E. Adriaenssens, Frank Reimann
Relaxin/insulin-like-family peptide receptor-4 (RXFP4), the cognate receptor for insulin-like peptide 5 (INSL5), has been implicated in feeding behaviour as Rxfp4 knockout mice display shorter meal durations and reduced high fat diet (HFD) intake. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d214b52ed8de0495597fbbef94a12b4d
https://doi.org/10.1101/2021.06.26.450020
https://doi.org/10.1101/2021.06.26.450020
Autor:
Frank Reimann, Rachel E. Foreman, Christopher A. Smith, Fiona M. Gribble, Van B. Lu, Emily L. Miedzybrodzka, Deborah A. Goldspink, Lawrence J. Billing, Richard G. Kay
Publikováno v:
Cell Reports
Cell Reports, Vol 31, Iss 13, Pp 107833-(2020)
Cell Reports, Vol 31, Iss 13, Pp 107833-(2020)
Summary Glucagon-like peptide-1 (GLP-1) from intestinal L-cells stimulates insulin secretion and reduces appetite after food ingestion, and it is the basis for drugs against type-2 diabetes and obesity. Drugs targeting L- and other enteroendocrine ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a59c03d7748a25d43dc5b773650b3d
http://europepmc.org/articles/PMC7342002
http://europepmc.org/articles/PMC7342002
Publikováno v:
eLife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::ff6796e6db0305bba183196984705b2d
Autor:
Christopher A. Smith, Richard G. Kay, Rachel E. Foreman, Van B. Lu, Emily L. Miedzybrodzka, Deborah A. Goldspink, Lawrence J. Billing, Frank Reimann, Fiona M. Gribble
Publikováno v:
SSRN Electronic Journal.
GLP-1 from intestinal L-cells stimulates insulin secretion and reduces appetite after food ingestion, and is the basis for drugs against type-2 diabetes and obesity. Drugs targeting L- and other enteroendocrine cells are under development, aiming to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70917d6f3bdd3590b4f6ab7ec4dac8b0
https://doi.org/10.2139/ssrn.3564983
https://doi.org/10.2139/ssrn.3564983