Inhibitors of the small membrane (M) protein viroporin prevent Zika virus infection

Autor: Emma Brown, Gemma Swinscoe, Daniella A Lefteri, Ravi Singh, Amy Moran, Rebecca F Thompson, Daniel Maskell, Hannah Beaumont, Matthew J Bentham, Claire Donald, Alain Kohl, Andrew Macdonald, Neil Ranson, Richard Foster, Clive S McKimmie, Antreas C Kalli, Stephen Griffin

Publikováno v: eLife, Vol 13 (2024)

Flaviviruses, including Zika virus (ZIKV), are a significant global health concern, yet no licensed antivirals exist to treat disease. The small membrane (M) protein plays well-defined roles during viral egress and remains within virion membranes fol

Externí odkaz: https://doaj.org/article/2ea2a660429141029618f43cf5ee6d6c

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

Autor: Joseph Shaw, Rajendra Gosain, Monoj Mon Kalita, Toshana L Foster, Jayakanth Kankanala, D Ram Mahato, Sonia Abas, Barnabas J King, Claire Scott, Emma Brown, Matthew J Bentham, Laura Wetherill, Abigail Bloy, Adel Samson, Mark Harris, Jamel Mankouri, David J Rowlands, Andrew Macdonald, Alexander W Tarr, Wolfgang B Fischer, Richard Foster, Stephen Griffin

Publikováno v: eLife, Vol 9 (2020)

Since the 1960s, a single class of agent has been licensed targeting virus-encoded ion channels, or ‘viroporins’, contrasting the success of channel blocking drugs in other areas of medicine. Although resistance arose to these prototypic adamanta

Externí odkaz: https://doaj.org/article/3401ae4371944442844f8b367aa9f459

A Non-Adiabatic Model for Jacketed Agitated Batch Reactors Experiencing Thermal Losses

Autor: Karrar H. Al-Dirawi, Peter J. Heggs, Michael S. Johnson, Tariq Mahmud, Erik J. Bentham

Publikováno v: Industrial & Engineering Chemistry Research. 60:1316-1325

Accurate modeling of process temperatures within jacketed batch reactors has the potential to mitigate the risk of thermal runaways and enhance process control. A non-adiabatic heat-transfer model is derived for the investigation of heat transfer in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d96edef10d372ecd27e570616458900
https://doi.org/10.1021/acs.iecr.0c05133

Shelterbelt Agroforestry Systems Inventory and Removal Analyzed by Object-based Classification of Satellite Data in Saskatchewan, Canada

Autor: Murray J. Bentham, Kenneth Belcher, Thuan V. Ha, Suren Kulshreshtha, Ken C.J. Van Rees, Colin P. Laroque, Beyhan Y. Amichev

Publikováno v: Canadian Journal of Remote Sensing. 45:246-263

Shelterbelt agroforestry systems inventory is challenging given their narrow linear feature and extensive distribution. The objective of this study was to evaluate the capability of Sentine...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b361cdff08ca5350f336fc9d61e6c7e7
https://doi.org/10.1080/07038992.2018.1540297

Assessing life cycle impacts from changes in agricultural practices of crop production:Methodological description and case study of microbial phosphate inoculant

Autor: Claus Nordstrøm Scheel, Murray J. Bentham, Brian Grant, Jannick Højrup Schmidt, Jesper Hedal Kløverpris, Ward Smith

Publikováno v: Kløverpris, J H, Scheel, C N, Schmidt, J, Grant, B, Smith, W & Bentham, M J 2020, ' Assessing life cycle impacts from changes in agricultural practices of crop production : Methodological description and case study of microbial phosphate inoculant ', International Journal of Life Cycle Assessment, vol. 25, no. 10, pp. 1991-2007 . https://doi.org/10.1007/s11367-020-01767-z

Purpose This paper presents an improved methodological approach for studying life cycle impacts (especially global warming) from changes in crop production practices. The paper seeks to improve the quantitative assessment via better tools and it seek

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f80bc624025edc59e99f8a9fcdf5b4
https://vbn.aau.dk/da/publications/54da6df8-b106-496a-be94-74a63c6f3e47