Zobrazeno 1 - 10
of 192
pro vyhledávání: '"J. Balic"'
Autor:
Jesse J. Balic, Hassan Albargy, Kevin Luu, Francis J. Kirby, W. Samantha N. Jayasekara, Finbar Mansell, Daniel J. Garama, Dominic De Nardo, Nikola Baschuk, Cynthia Louis, Fiachra Humphries, Katherine Fitzgerald, Eicke Latz, Daniel J. Gough, Ashley Mansell
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
TLR4 signalling can reprogram the metabolism of macrophages to be more glycolytic and proinflammatory. Here the authors show that LPS and TLR4 signalling results in recruitment of TBK1, which in turn phosphorylates serine 727 on STAT3 to enable a pro
Externí odkaz:
https://doaj.org/article/56d3ddfe137f4fb1a1f4f01e629a3c2e
Autor:
Mohamed I Saad, Sultan Alhayyani, Louise McLeod, Liang Yu, Mohammad Alanazi, Virginie Deswaerte, Ke Tang, Thierry Jarde, Julian A Smith, Zdenka Prodanovic, Michelle D Tate, Jesse J Balic, D Neil Watkins, Jason E Cain, Steven Bozinovski, Elizabeth Algar, Tomohiro Kohmoto, Hiromichi Ebi, Walter Ferlin, Christoph Garbers, Saleela Ruwanpura, Irit Sagi, Stefan Rose‐John, Brendan J Jenkins
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 4, Pp 1-19 (2019)
Abstract Oncogenic KRAS mutations are major drivers of lung adenocarcinoma (LAC), yet the direct therapeutic targeting of KRAS has been problematic. Here, we reveal an obligate requirement by oncogenic KRAS for the ADAM17 protease in LAC. In genetica
Externí odkaz:
https://doaj.org/article/651450bcc02047a78683c22380e772e6
Autor:
Brendan J. Jenkins, Gregory J. Goodall, Masanobu Oshima, Patrick Tan, Jie Qi Mao, Ji Kun Li, Catherine L. Kennedy, You Dong Liu, Tae-Su Han, Anna Tsykin, Jesse J. Balic, Hugh Gao, Di Wu, Liang Yu
These figures and tables contain supporting (and essential) data to confirm the clinical utility of the miR-200 family and signature in early gastric cancer, as well as its regulation by STAT3. Supplementary Figure S1. The association of WHO intestin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3125502252ac32dcd71955187e961f
https://doi.org/10.1158/1078-0432.22460808.v1
https://doi.org/10.1158/1078-0432.22460808.v1
Autor:
Brendan J. Jenkins, Daniel J. Gough, Prithi S. Bhathal, Thaleia Livis, Alice J. West, Alison C. West, Liang Yu, Mohamed I. Saad, Daniel J. Garama, Jesse J. Balic
Deregulated activation of the latent oncogenic transcription factor STAT3 in many human epithelial malignancies, including gastric cancer, has invariably been associated with its canonical tyrosine phosphorylation and enhanced transcriptional activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f45c44b56603ba8788cdd102c63de96
https://doi.org/10.1158/0008-5472.c.6511035
https://doi.org/10.1158/0008-5472.c.6511035
Autor:
Brendan J. Jenkins, Daniel J. Gough, Prithi S. Bhathal, Thaleia Livis, Alice J. West, Alison C. West, Liang Yu, Mohamed I. Saad, Daniel J. Garama, Jesse J. Balic
File containing essential supplementary figures (7) and tables (3) comprising pre-clinical mouse model and clinical data supporting the role of constitutive pS-STAT3 in gastric cancer. This file also contains additional supplementary methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ad85e798a18234015c0d12c08ac240
https://doi.org/10.1158/0008-5472.22421796.v1
https://doi.org/10.1158/0008-5472.22421796.v1
Autor:
Brendan J. Jenkins, Gregory J. Goodall, Masanobu Oshima, Patrick Tan, Jie Qi Mao, Ji Kun Li, Catherine L. Kennedy, You Dong Liu, Tae-Su Han, Anna Tsykin, Jesse J. Balic, Hugh Gao, Di Wu, Liang Yu
Purpose: The majority of gastric cancer patients are diagnosed with late-stage disease, for which distinct molecular subtypes have been identified that are potentially amenable to targeted therapies. However, there exists no molecular classification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d3b31fc9a6d3617cbd38d6ba6f3317
https://doi.org/10.1158/1078-0432.c.6524598.v1
https://doi.org/10.1158/1078-0432.c.6524598.v1
Autor:
Ke Tang, Louise McLeod, Thaleia Livis, Alison C. West, Ruby Dawson, Liang Yu, Jesse J. Balic, Michelle Chonwerawong, Georgie Wray-McCann, Hiroko Oshima, Masanobu Oshima, Virginie Deswaerte, Richard L. Ferrero, Brendan J. Jenkins
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology. 14:567-586
Gastric cancer (GC) is strongly linked with chronic gastritis after Helicobacter pylori infection. Toll-like receptors (TLRs) are key innate immune pathogenic sensors that mediate chronic inflammatory and oncogenic responses. Here, we investigated th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b94447ddcb4b0c8afe31f491f4237d
https://doi.org/10.1016/j.jcmgh.2022.06.002
https://doi.org/10.1016/j.jcmgh.2022.06.002
Autor:
Katie A. Fennell, Dane Vassiliadis, Enid Y. N. Lam, Luciano G. Martelotto, Jesse J. Balic, Sebastian Hollizeck, Tom S. Weber, Timothy Semple, Qing Wang, Denise C. Miles, Laura MacPherson, Yih-Chih Chan, Andrew A. Guirguis, Lev M. Kats, Emily S. Wong, Sarah-Jane Dawson, Shalin H. Naik, Mark A. Dawson
Publikováno v:
Nature. 601:125-131
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eca5ec36241dd90dcfbc07c2d0e36859
https://doi.org/10.1038/s41586-021-04206-7
https://doi.org/10.1038/s41586-021-04206-7
Autor:
Zdenka Prodanovic, Saleela Ruwanpura, Brendan J. Jenkins, Beena Kumar, Liang Yu, Steven Bozinovski, Christopher Hodges, Sultan Alhayyani, Louise McLeod, Alison C. West, Jesse J. Balic, Mohamed I. Saad, Julian A. Smith
Publikováno v:
Oncogene. 41:809-823
The oncogenic potential of the latent transcription factor signal transducer and activator of transcription (STAT)3 in many human cancers, including lung cancer, has been largely attributed to its nuclear activity as a tyrosine-phosphorylated (pY705
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18d2300730897837b0813be8df1f3379
https://doi.org/10.1038/s41388-021-02134-4
https://doi.org/10.1038/s41388-021-02134-4
Autor:
Youdong Liu, Yuqin Yang, Mili Zhang, Dakang Xu, Le Ying, Baokun He, jikun li, Duogang Xu, Di Wu, Lei Zhang, Jesse J. Balic, Brendan J. Jenkins, Qisheng Gu, Hugh Gao, Xu Li, Can Cao, Liang Yu
Publikováno v:
Oncogene
The EMT (epithelial-to-mesenchymal-transition) subtype of gastric cancer (GC) is associated with poor treatment responses and unfavorable clinical outcomes. Despite the broad physiological roles of the micro-RNA (miR)-200 family, they largely serve t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023aa3a2f51845e6ff73c90fa2deeb3b
https://doi.org/10.1038/s41388-021-02067-y
https://doi.org/10.1038/s41388-021-02067-y