Zobrazeno 1 - 10
of 75
pro vyhledávání: '"J. BRLIK"'
Autor:
Mária Kajtár-Peredy, Juhasz Imre, J. Brlik, Lajos Szabo, György Kalaus, Csaba Szántay, István Greiner, János Éles
Publikováno v:
Journal of Heterocyclic Chemistry. 37:245-251
The individual epimerization steps of vincadifformine (1), deethylvincadifformine isomers (2,3), their synthetic intermediates (4–13) as well as that of simpler compounds with D-secoaspidospermane skeleton (15–17) were studied a) in protic medium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da15848a8f442240b2e4c34cd9dae448
https://doi.org/10.1002/jhet.5570370205
https://doi.org/10.1002/jhet.5570370205
Autor:
Anna Laukó, Peter Horvath, Sándor Görög, Katalin Varga, G. Balogh, J. Brlik, Mónika Babják, M. Gazdag, F. Dravecz
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 18:511-525
Due to the varied reactions leading to the 3-oxo group in steroids and the reactivity of its environment, a large number of impurities related to this group are formed during the reaction steps and the degradation studies. In this paper the experienc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f02d718a861d59299d26f84e627da25
https://doi.org/10.1016/s0731-7085(98)00206-4
https://doi.org/10.1016/s0731-7085(98)00206-4
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 17:1029-1036
Reversed-phase HPLC methods using C-18 and C-8 columns as well as various isocratic and gradient systems with aqueous ammonium acetate, methanol and acetonitrile are described for the separation of the impurities of mazipredone (11beta,17-dihydroxy-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f56c6821d94e022c9bda7a49330881
https://doi.org/10.1016/s0731-7085(98)00068-5
https://doi.org/10.1016/s0731-7085(98)00068-5
Autor:
S. Görög, Katalin Varga, J. Brlik, G. Balogh, F. Dravecz, A. Laukó, A. Csehi, M. Gasdag, Peter Horvath, M. Babják
Publikováno v:
Talanta. 44:1517-1526
A general scheme is set up for the estimation of the impurity profile of bulk drug substances by the complex use of chromatographic, spectroscopic and hyphenated techniques. Several examples are presented as illustrations to the scheme from the autho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80563eb5490d3eab3b0f1e95b7ab7e7d
https://doi.org/10.1016/s0039-9140(96)02179-0
https://doi.org/10.1016/s0039-9140(96)02179-0
Autor:
Katalin Varga, Peter Horvath, S. Görög, A. Csehi, F. Dravecz, M. Rényei, G. Balogh, Anna Laukó, J. Brlik, Zs. Halmos
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 15:1343-1349
A new apolar impurity (3,17 alpha-diethinyl-13-ethyl-3,5-gonadiene-17-ol, IIb) was detected and identified in norgestrel with the aid of thin-layer and high-performance chromatography and spectroscopic techniques. IIb is the product of the acid-catal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d800195c2ba1168a696d77e5a347ddf0
https://doi.org/10.1016/s0731-7085(96)02008-0
https://doi.org/10.1016/s0731-7085(96)02008-0
Autor:
J. Brlik, Peter Horvath, Zs. Halmos, M. Kislaki, Gy. Domany, A. Nemes, Cs. Szantay, Katalin Varga, S. Görög, A. Csehi
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 15:1-5
Besides several known impurities in cimetidine, two additional compounds at levels below 0.1% were detected by ion-pair reversed-phase high-performance liquid chromatography (HPLC). The impurities were isolated from crude cimetidine using normal-phas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5284772ad789f5f5aeb5f59478581788
https://doi.org/10.1016/0731-7085(96)01815-8
https://doi.org/10.1016/0731-7085(96)01815-8
Autor:
Lajos Szabo, Istvan Vago, Mária Kajtár Peredy, György Kalaus, István Greiner, J. Brlik, Csaba Szántay
Publikováno v:
Natural Product Letters. 7:197-204
Reaction of compound (4) with (5) give a mixture of the isomers (7) and (8) through the intermediate (1). Further conversions led through the oxo- (9), (10) and thioxo (11), (12) derivatives to (±)-19-ethoxycarbonyl-19-demethylvincadifformine (3), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d284e9df205b409a77d08c6c4310c3e0
https://doi.org/10.1080/10575639508043211
https://doi.org/10.1080/10575639508043211
Autor:
György Kalaus, Juhasz Imre, Mária Kajtár-Peredy, István Greiner, Lajos Szabo, Csaba Szántay, J. Brlik
Publikováno v:
Liebigs Annalen. 1995:1245-1251
The reaction of the key compound 14 with methyl 4-formyl-butanoate (9) or with 5-benzoyloxypentanal (13) gave the D-seco-aspidospermane derivatives 17 and 18, respectively. Compound 17 was indirectly and 18 was directly converted to (±)-20-deethylvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bfc1b06de31de4f193110c0c570ae5f
https://doi.org/10.1002/jlac.1995199507165
https://doi.org/10.1002/jlac.1995199507165
Publikováno v:
Scopus-Elsevier
Using our previously reported convergent synthetic strategy, secondary amine, methyl 2-[3-(2-[benzylamino]ethyl)indol-2-yl]-3-hydroxypropionate (6), and aldehyde, ethyl 2-ethyl-4-formylbutanoate (9), reacted to give tetracyclic esters ,pyrrolo[2,3-d]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b01f4588e200c45095db55fbc47e68f
https://doi.org/10.1021/jo00074a039
https://doi.org/10.1021/jo00074a039
Publikováno v:
The Journal of Organic Chemistry. 58:1434-1442
Compound 3, which has an indole skeleton containing a masked acryl ester function, was synthesized from the hydrochloride of 2-(ethorycarbonyl)tryptamine (2). The cycloaddition of 3 with methyl 4-formylhexanoate (21) or with 5-(benzoylocy)-2-ethylpen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16702ec89f221235ed0260bf0e18e646
https://doi.org/10.1021/jo00058a025
https://doi.org/10.1021/jo00058a025