Zobrazeno 1 - 10
of 1 345
pro vyhledávání: '"J. BIRNBAUM"'
Autor:
Stephen E Flaherty III, Olivier Bezy, Brianna LaCarubba Paulhus, LouJin Song, Mary Piper, Jincheng Pang, Yoson Park, Shoh Asano, Yu-Chin Lien, John D Griffin, Andrew Robertson, Alan Opsahl, Dinesh Hirenallur Shanthappa, Youngwook Ahn, Evanthia Pashos, Rebecca A Simmons, Morris J Birnbaum, Zhidan Wu
Publikováno v:
eLife, Vol 12 (2024)
From a forward mutagenetic screen to discover mutations associated with obesity, we identified mutations in the Spag7 gene linked to metabolic dysfunction in mice. Here, we show that SPAG7 KO mice are born smaller and develop obesity and glucose into
Externí odkaz:
https://doaj.org/article/4c48137f953943ab9ab7d2ee4fda5031
Autor:
Stephen E. Flaherty, Olivier Bezy, Wei Zheng, Dong Yan, Xiangping Li, Srinath Jagarlapudi, Bina Albuquerque, Ryan M. Esquejo, Matthew Peloquin, Meriem Semache, Arturo Mancini, Liya Kang, Doreen Drujan, Susanne B. Breitkopf, John D. Griffin, Pierre M. Jean Beltran, Liang Xue, John Stansfield, Evanthia Pashos, Quazi Shakey, Christian Pehmøller, Mara Monetti, Morris J. Birnbaum, Jean-Philippe Fortin, Zhidan Wu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Urocortin 2 (UCN2) acts as a ligand for the G protein-coupled receptor corticotropin-releasing hormone receptor 2 (CRHR2). UCN2 has been reported to improve or worsen insulin sensitivity and glucose tolerance in vivo. Here we show that acute
Externí odkaz:
https://doaj.org/article/c30f771320644d0bb5638ece93bbd9e2
Autor:
John D. Griffin, Joanne M. Buxton, Jeffrey A. Culver, Robert Barnes, Emily A. Jordan, Alexis R. White, Stephen E. Flaherty, Barbara Bernardo, Trenton Ross, Kendra K. Bence, Morris J. Birnbaum
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101830- (2023)
Objective: The liver is a central regulator of energy metabolism exerting its influence both through intrinsic processing of substrates such as glucose and fatty acid as well as by secreting endocrine factors, known as hepatokines, which influence me
Externí odkaz:
https://doaj.org/article/c24bdc42ed0a49f18fde932dcb90408d
Autor:
Anaïs Aulas, Maria Lucia Liberatoscioli, Pascal Finetti, Olivier Cabaud, David J. Birnbaum, Lucas Usclade, Daniel Birnbaum, François Bertucci, Emilie Mamessier
Publikováno v:
Cancer Communications, Vol 42, Iss 8, Pp 793-797 (2022)
Externí odkaz:
https://doaj.org/article/491aad5dabbe4e17a539f8d05f24f971
Autor:
Jose M. Garcia, Richard F. Dunne, Kristen Santiago, Lisa Martin, Morris J. Birnbaum, Jeffrey Crawford, Andrew E. Hendifar, Martin Kochanczyk, Cassadie Moravek, Doris Piccinin, Vincent Picozzi, Eric J. Roeland, Wendy K.D. Selig, Teresa A. Zimmers
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 2, Pp 1418-1425 (2022)
Externí odkaz:
https://doaj.org/article/1ddd00e55eb746dfa77b6814140d5643
Autor:
Kendra K. Bence, Morris J. Birnbaum
Publikováno v:
Molecular Metabolism, Vol 50, Iss , Pp 101143- (2021)
Background: The incidence of non-alcoholic fatty liver disease (NAFLD) is rapidly increasing worldwide parallel to the global obesity epidemic. NAFLD encompasses a range of liver pathologies and most often originates from metabolically driven accumul
Externí odkaz:
https://doaj.org/article/7677ba72ae8b4601ba5bd33defb08038
Autor:
Austin L. Good, Corey E. Cannon, Matthew W. Haemmerle, Juxiang Yang, Diana E. Stanescu, Nicolai M. Doliba, Morris J. Birnbaum, Doris A. Stoffers
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 95-106 (2019)
Objective: In type 2 diabetes (T2D), oxidative stress contributes to the dysfunction and loss of pancreatic β cells. A highly conserved feature of the cellular response to stress is the regulation of mRNA translation; however, the genes regulated at
Externí odkaz:
https://doaj.org/article/49f72e95647f4aa0be1c4d9996d87bb3
Autor:
Jemy A. Gutierrez, Wei Liu, Sylvie Perez, Gang Xing, Gabriele Sonnenberg, Kou Kou, Matt Blatnik, Richard Allen, Yan Weng, Nicholas B. Vera, Kristin Chidsey, Arthur Bergman, Veena Somayaji, Collin Crowley, Michelle F. Clasquin, Anu Nigam, Melissa A. Fulham, Derek M. Erion, Trenton T. Ross, William P. Esler, Thomas V. Magee, Jeffrey A. Pfefferkorn, Kendra K. Bence, Morris J. Birnbaum, Gregory J. Tesz
Publikováno v:
Molecular Metabolism, Vol 48, Iss , Pp 101196- (2021)
Objective: Recent studies suggest that excess dietary fructose contributes to metabolic dysfunction by promoting insulin resistance, de novo lipogenesis (DNL), and hepatic steatosis, thereby increasing the risk of obesity, type 2 diabetes (T2D), non-
Externí odkaz:
https://doaj.org/article/83d51c2650cb4492a69b4c32dbb702cc
Autor:
Florent Darriet, Nadim Cassir, David J. Birnbaum, Jérôme Soussan, Estelle Menu, Stéphane Ranque, Coralie L’Ollivier
Publikováno v:
IDCases, Vol 21, Iss , Pp e00843- (2020)
Autochthonous hydatidosis in France and western Europa are uncommon since the beginning of the 21st century. We report here an authentic indigenous cystic echinococcosis case in a French shepherd. The risk of remerging pathology should not be neglect
Externí odkaz:
https://doaj.org/article/bb5b877d04c547fda7575846a1395c4e
Autor:
Ryan M. Esquejo, Christopher T. Salatto, Jake Delmore, Bina Albuquerque, Allan Reyes, Yuji Shi, Rob Moccia, Emily Cokorinos, Matthew Peloquin, Mara Monetti, Jason Barricklow, Eliza Bollinger, Brennan K. Smith, Emily A. Day, Chuong Nguyen, Kieran F. Geoghegan, John M. Kreeger, Alan Opsahl, Jessica Ward, Amit S. Kalgutkar, David Tess, Lynne Butler, Norimitsu Shirai, Timothy F. Osborne, Gregory R. Steinberg, Morris J. Birnbaum, Kimberly O. Cameron, Russell A. Miller
Publikováno v:
EBioMedicine, Vol 31, Iss , Pp 122-132 (2018)
Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to cardiometabolic health, resulting in excessive liver lipid accumulation and ultimately non-alcoholic steatohepatitis (NASH). Therapeutic activators of the AMP-A
Externí odkaz:
https://doaj.org/article/3a6b1a8ecd964eee8550aafb2b27ef05