Výsledky vyhledávání - "J. B. Lawrence"

Safety and dose-dependency of eptacog beta (activated) in a dose escalation study of non-bleeding congenital haemophilia A or B patients, with or without inhibitors

Autor: Lisa N. Boggio, A. Bellon, J. B. Lawrence, Jasper Stevens, Matthijs Moerland, Michael Wang, Jonathan M. Ducore, J. Frieling, Jacobus Burggraaf, Mindy L. Simpson, Joannes A. A. Reijers

Publikováno v: Haemophilia. 23:844-851

Introduction Varying initial doses of activated eptacog beta (recombinant human FVIIa, rhFVIIa) may provide therapeutic options when treating bleeding in patients with congenital haemophilia who have developed inhibitory antibodies to factor VIII (FV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3812219c3d693d11776aa740e173950d
https://doi.org/10.1111/hae.13357

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PERSEPT 1: a phase 3 trial of activated eptacog beta for on-demand treatment of haemophilia inhibitor-related bleeding

Autor: Jonathan M. Ducore, W. A. Alexander, Mindy L. Simpson, Lisa N. Boggio, J.-F. Schved, Ian S. Mitchell, G. Yuan, Michael Wang, Doris Quon, J. B. Lawrence

Publikováno v: Haemophilia : the official journal of the World Federation of Hemophilia. 23(6)

Introduction Haemophilia A or B patients with inhibitors have been treated with FVIIa-containing bypassing agents for over 20 years. However, due to uncertainty regarding dose response and thrombotic risk, the use of a gradual, titrated, minimal dosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d86ccab3b1d4a12b42c8e86511c3f52
https://pubmed.ncbi.nlm.nih.gov/28776894

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Relationship of lipoprotein(a) with intimal medial thickness of the carotid artery in Type 2 diabetic patients in south India

Autor: Raj Deepa, Enas A. Enas, R. Ravikumar, M. Senthilvelmurugan, Kaliyaperumal Velmurugan, J. B. Lawrence, H. Anshoo, Viswanathan Mohan

Publikováno v: Diabetic Medicine. 20:455-461

OBJECTIVE: The objective of this study was to investigate the association of lipoprotein(a) [Lp(a)] levels with intimal medial thickness (IMT) in Type 2 diabetic patients in south India. STUDY DESIGN: We studied 587 consecutive Type 2 diabetic patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24b1da197591f7946342f91be3fc871
https://doi.org/10.1046/j.1464-5491.2003.00976.x

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Premature termination codon in the aggrecan gene of nanomelia and its influence on mRNA transport and stability

Autor: D, Primorac, C V, Johnson, J B, Lawrence, M B, McKinstry, M L, Stover, M S, Schanfield, S, Andjelinovic, T, Tadic, D W, Rowe

Publikováno v: Croatian medical journal. 40(4)

To analyze the influence of the premature termination codon on mRNA transport and stabilityChondrocyte mRNA was isolated from homozygous and heterozygous nanomelic 17-days old embryos and examined by RT-PCR analysis. To analyze aggrecan mRNA stabilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9b900c003f421e5cf55c23648f6123a
https://pubmed.ncbi.nlm.nih.gov/10554355

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Evaluation of continuous infusion suramin in metastatic breast cancer: impact on plasma levels of insulin-like growth factors (IGFs) and IGF-binding proteins

Autor: J B, Lawrence, C A, Conover, T C, Haddad, J N, Ingle, J M, Reid, M M, Ames, V J, Suman, R S, Marks, C, Erlichman, L C, Hartmann

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 3(10)

Suramin represents a new class of antitumor drugs that targets growth factor networks. In this Phase II trial, suramin was administered by continuous infusion to 10 patients with advanced breast cancer. The target level of 280 microgram/ml suramin wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a9c7d7263b243e7af5b4a37e58e587c
https://pubmed.ncbi.nlm.nih.gov/9815555

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'Prize Biochemical Analysis' 1992

Autor: J B, Lawrence

Publikováno v: European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. 30(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e4f6e9e5f902a401e429b8753db86d29
https://pubmed.ncbi.nlm.nih.gov/1525266

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The HIV-1 Rev protein: a model system for coupled RNA transport and translation

Autor: J B, Lawrence, A W, Cochrane, C V, Johnson, A, Perkins, C A, Rosen

Publikováno v: The New biologist. 3(12)

The impact of the Rev protein of the human immunodeficiency virus type 1 (HIV-1) on RNA transport, intranuclear RNA distribution, and gene expression was examined for two Rev-dependent expression systems by means of fluorescence in situ hybridization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::448b3deb5db164b9e400372cb8fb2df8
https://pubmed.ncbi.nlm.nih.gov/1725960

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The prototypical Epstein-Barr virus-transformed lymphoblastoid cell line IB4 is an unusual variant containing integrated but no episomal viral DNA

Autor: J B Lawrence, L D Klaman, David A. Thorley-Lawson, E A Hurley, S Agger

Publikováno v: Journal of virology. 65(7)

IB4 is a prototype, latently Epstein-Barr virus (EBV)-infected, lymphoblastoid cell line. We show here that IB4 contains only integrated EBV genomes. Episomal EBV DNA is not detected by Gardella gel analysis or in situ hybridization. Restriction enzy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39861c8746dab8bb7c1ad9237f3c8758
https://pubmed.ncbi.nlm.nih.gov/1645805

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