Zobrazeno 1 - 10
of 23
pro vyhledávání: '"J. B., Harvey"'
Autor:
Bruno Perlatti, Connie B. Nichols, Nan Lan, Philipp Wiemann, Colin J. B. Harvey, J. Andrew Alspaugh, Gerald F. Bills
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Cryptococcus neoformans is an important human pathogen with limited options for treatments. We have interrogated extracts from fungal fermentations to find Cryptococcus-inhibiting natural products using assays for growth inhibition, differential ther
Externí odkaz:
https://doaj.org/article/e7f73788d6f24d7b8334d7dc37a565e2
Autor:
Philipp Wiemann, Bruno Perlatti, Jens Christian Frisvad, Zhiqiang An, Nan Lan, Daniel J. Kvitek, Colin J. B. Harvey, Gerald F. Bills
Publikováno v:
Environmental Microbiology. 22:2292-2311
The antifungal echinocandin lipopeptide, acrophiarin, was circumscribed in a patent in 1979. We confirmed that the producing strain NRRL 8095 is Penicillium arenicola and other strains of P. arenicola produced acrophiarin and acrophiarin analogues. G
Autor:
Robert P. St.Onge, Joe Horecka, Ulrich Schlecht, Ronald W. Davis, Ana Aparicio, Colin J. B. Harvey, Kristen Kolberg, Maureen E. Hillenmeyer, Jian Li
Publikováno v:
Journal of Biological Chemistry. 294:1257-1266
Multidrug resistance is highly conserved in mammalian, fungal, and bacterial cells, is characterized by resistance to several unrelated xenobiotics, and poses significant challenges to managing infections and many cancers. Eukaryotes use a highly con
Autor:
J. Andrew Alspaugh, Connie B. Nichols, Gerald F. Bills, Bruno Perlatti, Colin J. B. Harvey, Nan Lan, James B. Gloer, Cody E. Earp, Meichun Xiang, Joseph E Spraker
Publikováno v:
Journal of industrial microbiologybiotechnology. 48(9-10)
Cryptococcus neoformans is a serious human pathogen with limited options for treatment. We have interrogated extracts from fungal fermentations to find Cryptococcus-inhibiting natural products using assays for growth inhibition and differential therm
Autor:
Colin J. B. Harvey
Fungi are prolific producers of structurally diverse and bioactive natural products. The past decade has seen impressive growth in our understanding of the biosynthesis of these important molecules and engineering Saccharomyces cerevisiae for their h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::317041ec1df7ac400cadb5dc5204896f
https://doi.org/10.1016/b978-0-12-409547-2.14741-9
https://doi.org/10.1016/b978-0-12-409547-2.14741-9
Autor:
Nicholas Liu, Leibniz Hang, Claire G. Page, Yi Tang, Maureen E. Hillenmeyer, Yiu-Sun Hung, Man-Cheng Tang, Jian Li, Colin J. B. Harvey
Publikováno v:
Angewandte Chemie. 129:9684-9688
Fungal polyketides have significant biological activities, yet the biosynthesis by highly reducing polyketide synthases (HRPKSs) remains enigmatic. An uncharacterized group of HRPKSs was found to contain a C-terminal domain with significant homology
Autor:
Maureen E. Hillenmeyer, Gergana A. Vandova, Robert V. O’Brien, Curt R. Fischer, Brian Lowry, Chaitan Khosla, Thomas Robbins, Ronald W. Davis, Colin J. B. Harvey
Publikováno v:
The Journal of Antibiotics
Heterologous expression of diverse propionyl-CoA carboxylases affects polyketide production in Escherichia coli
Autor:
Nan, Lan, Bruno, Perlatti, Daniel J, Kvitek, Philipp, Wiemann, Colin J B, Harvey, Jens, Frisvad, Zhiqiang, An, Gerald F, Bills
Publikováno v:
Environ Microbiol
The antifungal echinocandin lipopeptide, acrophiarin, was circumscribed in a patent in 1979. We confirmed that the producing strain NRRL 8095 is Penicillium arenicola and other strains of P. arenicola produced acrophiarin and acrophiarin analogues. G
Autor:
Ronald Davis, Maureen E. Hillenmeyer, Ulrich Schlecht, Jamie K. Li, Horecka Joseph L, R. P. St.Onge, Colin J. B. Harvey, Ana Aparicio, Kolberg K
SummaryEukaryotes utilize a highly-conserved set of drug efflux transporters to confer pleiotropic drug resistance (PDR). Despite decades of effort interrogating this process, multiple aspects of the PDR process, in particular PDR regulation, remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60fdde19fd7397007c8ea4dc801350e
Autor:
Ulrich Schlecht, Yi Tang, Brian Naughton, Ronald W. Davis, James Cherry, Yong Fuga Li, Diane O. Inglis, Raeka S. Aiyar, Maureen E. Hillenmeyer, Chaitan Khosla, Marnix H. Medema, Robert P. St.Onge, Angela M. Chu, Man-Cheng Tang, Molly Miranda, Joe Horecka, James R. Hennessy, Gergana A. Vandova, Jian Li, Lars M. Steinmetz, Elizabeth S. Sattely, Curt R. Fischer, Colin J. B. Harvey, Hsiao-Ching Lin
Publikováno v:
Science Advances 4 (2018) 4
Science Advances, 4(4)
Science Advances
Science Advances, 4(4)
Science Advances
We develop a novel synthetic biology platform for rapid, scalable expression of fungal biosynthetic genes and encoded metabolites.
For decades, fungi have been a source of U.S. Food and Drug Administration–approved natural products such as pen
For decades, fungi have been a source of U.S. Food and Drug Administration–approved natural products such as pen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5332f758d581660c96e0bd4b793045f
https://research.wur.nl/en/publications/hex-a-heterologous-expression-platform-for-the-discovery-of-funga
https://research.wur.nl/en/publications/hex-a-heterologous-expression-platform-for-the-discovery-of-funga