Zobrazeno 1 - 10
of 22
pro vyhledávání: '"J. Arturo Londoño-Vallejo"'
Autor:
Frank Buchholz, Clara Lopes Novo, J. Arturo Londoño-Vallejo, Michelle Stevense, Matthias Mann, Christian Benda, Dragomir B. Krastev, Claire Basquin, Rolf Jessberger, Irena Draskovic, Masatake Araki, Dennis Kappei, Kimi Araki, Marion Scheibe, Ralf Kittler, Falk Butter
Publikováno v:
EMBO Journal, 32, 1681-701
The EMBO Journal
EMBO Journal, 32, 12, pp. 1681-701
The EMBO Journal
EMBO Journal, 32, 12, pp. 1681-701
Telomeres are repetitive DNA structures that, together with the shelterin and the CST complex, protect the ends of chromosomes. Telomere shortening is mitigated in stem and cancer cells through the de novo addition of telomeric repeats by telomerase.
Autor:
J. Arturo Londoño-Vallejo
Publikováno v:
médecine/sciences. 25:973-976
Le prix Nobel de Medecine 2009 (le centieme a etre decerne) a ete attribue a Elizabeth Blackburn, Jack Szostak et Carol Greider pour leurs travaux sur les telomeres et la telomerase. Elizabeth Blackburn, nee en 1948, possede la double nationalite ame
Autor:
Graeme A.M. Nimmo, J. Arturo Londoño-Vallejo, Delphine T. Marie-Egyptienne, Marie Eve Brault, Chantal Autexier
Publikováno v:
Cancer Letters. 275:266-276
Cellular viability requires telomere maintenance, which, in mammals, is mainly mediated by the reverse transcriptase telomerase. Telomerase core components are a catalytic subunit TERT and an RNA subunit TR (hTR in humans, mTR in mouse) that carries
Autor:
Eric Gilson, J. Arturo Londoño-Vallejo
Publikováno v:
Cell Cycle
Cell Cycle, Taylor & Francis, 2007, 6 (20), pp.2486-2494
HAL
Cell Cycle, 2007, 6 (20), pp.2486-2494
Cell Cycle, Taylor & Francis, 2007, 6 (20), pp.2486-2494
HAL
Cell Cycle, 2007, 6 (20), pp.2486-2494
Telomere length is an important parameter of telomere function since it determines number of aspects controlling chromosome stability and cell division. Since telomeres shorten with age in humans and premature aging syndromes are often associated wit
Autor:
Angelica Bellopede, Bakary S. Sylla, Massimo Tommasino, Susanne Popp, J. Arturo Londoño-Vallejo, Anne Sophie Gabet, Petra Boukamp, Rosita Accardi
Publikováno v:
The FASEB Journal. 22:622-632
The skin human papillomavirus (HPV) types belonging to the genus beta of the HPV phylogenetic tree appear to be associated with nonmelanoma skin cancer. We previously showed that the beta HPV type 38 E6 and E7 oncoproteins are able to inactivate the
Publikováno v:
Oncogene. 24:7893-7901
In human somatic cells proliferation results in telomere shortening due to the end replication problem and the absence of adequate levels of telomerase activity. The progressive loss of telomeric DNA has been associated with replicative senescence. M
Autor:
J. Arturo Londoño-Vallejo
Publikováno v:
Cancer Letters. 212:135-144
Chromosome aberrations are the hallmark of cancer cells. Although a few specific chromosome aberrations are frequently detected in some types of cancer, the majority of karyotypic abnormalities tend to differ between different histological types and
Autor:
Emmanuel Tubacher, J. Arturo Londoño-Vallejo, Jung-Eun Park, Vladimir Larionov, Jung-Hyun Kim, Hung Bui, Natalay Kouprina, Sun-Hee Leem, J. Carl Barrett, Greg Solomon, Izumi Horikawa
Publikováno v:
Oncogene. 21:769-777
In this work, the full-length hTERT gene was isolated and the sequence of the previously unknown region in intron 6 as well as that of upstream and downstream hTERT regions was determined. We have shown that intron 6 includes a variable number of tan
Publikováno v:
Human Molecular Genetics. 10:1945-1952
Immortal human cells maintain their telomeres by two independent mechanisms, a prevalent one dependent on de novo synthesis of telomeric DNA by telomerase, and a rarer one based on telomere recombination [alternative lengthening of telomeres (ALT)].
Publikováno v:
Nucleic Acids Research. 29:3164-3171
Telomeres are important structures for DNA replication and chromosome stability during cell growth. Telomere length has been correlated with the division potential of human cells and has been found to decrease with age in healthy individuals. Neverth