Výsledky vyhledávání - "J. Antonie Maassen"

Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B Affect Different Aspects of Pancreatic β-Cell Function

Autor: Dorret I. Boomsma, P. Eline Slagboom, Gonneke Willemsen, Mark H.H. Kramer, Erwin Reiling, Elisabeth M. W. Eekhoff, Eco J. C. de Geus, Leen M 't Hart, Michaela Diamant, Jacqueline M. Dekker, Giel Nijpels, A.M.C. Simonis-Bik, Jeanine J. Houwing-Duistermaat, Timon W. van Haeften, Els C. van Hove, J. Antonie Maassen, Robert J. Heine

Publikováno v: Diabetes
Diabetes, 59(1), 293-301
Bik-Simonis, A M C, Nijpels, M G A A M, van Haeften, T, Houwing-Duistermaat, J J, Boomsma, D I, Reiling, E, van Hove, E C, Diamant, M, Kramer, M H H, Heine, R J, Maassen, J A, Slagboom, P E, Willemsen, G, Dekker, J M, Eekhoff, E M W, de Geus, E J C & Hart, L M 2010, ' Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A and MTNR1B affect different aspects of pancreatic beta cell function ', Diabetes, vol. 59, no. 1, pp. 293-301 . https://doi.org/10.2337/db09-1048
Diabetes, 59(1), 293-301. American Diabetes Association Inc.

OBJECTIVE Recently, results from a meta-analysis of genome-wide association studies have yielded a number of novel type 2 diabetes loci. However, conflicting results have been published regarding their effects on insulin secretion and insulin sensiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712dee0a9c0be2d7d41b244de6dfba12
http://europepmc.org/articles/PMC2797936

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Phosphorus-31 Magnetic Resonance Spectroscopy of Skeletal Muscle in Maternally Inherited Diabetes and Deafness A3243G Mitochondrial Mutation Carriers

Autor: Saskia G. C. van Elderen, Joost Doornbos, Einar H R van Essen, Herman H.P.J. Lemkes, Albert de Roos, Jan W. A. Smit, J. Antonie Maassen

Publikováno v: van Elderen, S G C, Doornbos, J, van Essen, E H R, Lemkes, H H P J, Maassen, J A, Smit, J H A & de Roos, A 2009, ' Phosphorus-31 Magnetic Resonance Spectroscopy of Skeletal Muscle in Maternally Inherited Diabetes and Deafness A3243G Mitochondrial Mutation Carriers ', Journal of Magnetic Resonance Imaging, vol. 29, no. 1, pp. 127-131 . https://doi.org/10.1002/jmri.21620
Journal of Magnetic Resonance Imaging, 29(1), 127-131. John Wiley and Sons Inc.

Purpose To investigate high-energy phosphate metabolism in striated skeletal muscle of patients with Maternally Inherited Diabetes and Deafness (MIDD) syndrome. Materials and Methods In 11 patients with the MIDD mutation (six with diabetes mellitus [

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c75db48fb18eeedab1f2bb0873a7ee
https://hdl.handle.net/1871/46435

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The HADHSC Gene Encoding Short-Chain l-3-Hydroxyacyl-CoA Dehydrogenase (SCHAD) and Type 2 Diabetes Susceptibility

Autor: Knut Borch-Johnsen, Giel Nijpels, Torben Jørgensen, Yasmin H. Hamid, Jacqueline M. Dekker, Robert J. Heine, Torben Hansen, Oluf Pedersen, Erwin Reiling, Els C. van Hove, J. Antonie Maassen, Leen M 't Hart

Publikováno v: Diabetes. 55:3193-3196

The short-chain l-3-hydroxyacyl-CoA dehydrogenase (SCHAD) protein is involved in the penultimate step of mitochondrial fatty acid oxidation. Previously, it has been shown that mutations in the corresponding gene (HADHSC) are associated with hyperinsu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64862168bde46fcdca23f2242f9ac364
https://doi.org/10.2337/db06-0414

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Novel Mitochondrial DNA Length Variants and Genetic Instability in a Family with Diabetes and Deafness

Autor: C. M. T. Van De Sande, George M.C. Janssen, A. Neu, Leen M 't Hart, J. Antonie Maassen

Publikováno v: Experimental and Clinical Endocrinology & Diabetes. 114:168-174

We have identified two locations with novel multiplasmic length variants in the mitochondrial DNA of a family with diabetes and deafness. At nt568 in the D-loop, the 6-bp polycytidine tract was found to be variable in length up to a total of 12 resid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2b46d1fe21942d20de8da177e05837
https://doi.org/10.1055/s-2006-924066

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The role of c-Jun N-terminal kinase, p38, and extracellular signal-regulated kinase in insulin-induced Thr69 and Thr71 phosphorylation of activating transcription factor 2

Autor: J. Antonie Maassen, Hans van Dam, D. Margriet Ouwens, Gerard C.M. van der Zon, Bart Baan

Publikováno v: Molecular endocrinology (Baltimore, Md.), 20(8), 1786-1795. The Endocrine Society

The stimulation of cells with physiological concentrations of insulin induces a variety of responses, e.g. an increase in glucose uptake, induction of glycogen and protein synthesis, and gene expression. One of the determinants regulating insulin-med

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca25f4fe3b70009daf9c653f8685f91b
https://doi.org/10.1210/me.2005-0289

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Distinct nuclear gene expression profiles in cells with mtDNA depletion and homoplasmic A3243G mutation

Autor: Karoly Szuhai, Anton K. Raap, Peter J. Svensson, George M.C. Janssen, J. Antonie Maassen, Roshan S. Jahangir Tafrechi

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 578:43-52

The pathobiochemical pathways determining the wide variability in phenotypic expression of mitochondrial DNA (mtDNA) mutations are not well understood. Most pathogenic mtDNA mutations induce a general defect in mitochondrial respiration and thereby A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b978f023690c5ae190dd046cd7d31d4
https://doi.org/10.1016/j.mrfmmm.2005.02.002

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Rottlerin inhibits multiple steps involved in insulin-induced glucose uptake in 3T3-L1 adipocytes

Autor: Rob C. G. van de Ven, J. Antonie Maassen, Peter J.A. van den Broek, Gerard C.M. van der Zon, Merlijn Bazuine

Publikováno v: Biochemical pharmacology, 68(1), 105-112. Elsevier Inc.

Recently, it was shown that rottlerin inhibits insulin-stimulated glucose uptake and reduces intracellular adenosine triphosphate (ATP) levels in 3T3-L1 adipocytes, suggesting that these two events are causally linked. However, several other reports

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202e11196802bf4379065b1105a40e06
https://doi.org/10.1016/j.bcp.2004.02.032

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Genetic Factors and Insulin Secretion

Autor: Fausto Machicao, Robert J. Heine, Andreas Fritsche, Jacqueline M. Dekker, Leen M 't Hart, Timon W. van Haeften, Cornelia M. van Duijn, Giel Nijpels, Michael Stumvoll, Ingrid Rietveld, Hans U. Häring, J. Antonie Maassen

Publikováno v: Diabetes. 53:S26-S30

IGFs are important regulators of pancreatic β-cell development, growth, and maintenance. Mutations in the IGF genes have been found to be associated with type 2 diabetes, myocardial infarction, birth weight, and obesity. These associations could res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d28ab96135b8e6fe784f8f8b0cacb342
https://doi.org/10.2337/diabetes.53.2007.s26

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Lentiviral Vectors Efficiently Transduce Quiescent Mature 3T3-L1 Adipocytes

Autor: Merlijn Bazuine, Françoise Carlotti, Philippe Pognonec, Tuija Kekarainen, J. Antonie Maassen, Jurgen Seppen, Rob C. Hoeben

Publikováno v: Molecular therapy, 9(2), 209-217. Nature Publishing Group

Obesity is associated with many serious afflictions such as cardiovascular disease, cancer, and diabetes. One of the main cellular systems used to study the underlying physiological and biological processes is the 3T3-L1 preadipocyte differentiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b966b3f730828f9bd9e3ccc5a396d6
https://doi.org/10.1016/j.ymthe.2003.11.021

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Mitochondrial Diabetes

Autor: R.J. Heine, Giel Nijpels, George M.C. Janssen, Leen M 't Hart, Roshan S. Jahangir Tafrechi, Herman H.P.J. Lemkes, Anton K. Raap, J. Antonie Maassen, Einar H R van Essen

Publikováno v: Diabetes. 53:S103-S109

Mutations in mitochondrial DNA (mtDNA) associate with various disease states. A few mtDNA mutations strongly associate with diabetes, with the most common mutation being the A3243G mutation in the mitochondrial DNA-encoded tRNA(Leu,UUR) gene. This ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60908cdc3fc502427cf920fde529bc6a
https://doi.org/10.2337/diabetes.53.2007.s103

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