Zobrazeno 1 - 10
of 571
pro vyhledávání: '"J. Anson"'
Autor:
K. P., Sreenath1 (AUTHOR) kakkadsreenath@gmail.com, C. J., Anson1 (AUTHOR) ansoncj@cusat.ac.in
Publikováno v:
Journal of World Intellectual Property. Nov2023, Vol. 26 Issue 3, p339-356. 18p.
Autor:
Britton Boras, Rhys M. Jones, Brandon J. Anson, Dan Arenson, Lisa Aschenbrenner, Malina A. Bakowski, Nathan Beutler, Joseph Binder, Emily Chen, Heather Eng, Holly Hammond, Jennifer Hammond, Robert E. Haupt, Robert Hoffman, Eugene P. Kadar, Rob Kania, Emi Kimoto, Melanie G. Kirkpatrick, Lorraine Lanyon, Emma K. Lendy, Jonathan R. Lillis, James Logue, Suman A. Luthra, Chunlong Ma, Stephen W. Mason, Marisa E. McGrath, Stephen Noell, R. Scott Obach, Matthew N. O’ Brien, Rebecca O’Connor, Kevin Ogilvie, Dafydd Owen, Martin Pettersson, Matthew R. Reese, Thomas F. Rogers, Romel Rosales, Michelle I. Rossulek, Jean G. Sathish, Norimitsu Shirai, Claire Steppan, Martyn Ticehurst, Lawrence W. Updyke, Stuart Weston, Yuao Zhu, Kris M. White, Adolfo García-Sastre, Jun Wang, Arnab K. Chatterjee, Andrew D. Mesecar, Matthew B. Frieman, Annaliesa S. Anderson, Charlotte Allerton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The 3CL protease of SARS-CoV-2 is inhibited by PF-00835231 in vitro. Here, the authors show that the prodrug PF-07304814 has broad spectrum activity, inhibiting SARS-CoV and SARS-CoV-2 in mice and its ADME and safety profile support clinical developm
Externí odkaz:
https://doaj.org/article/7c0ac56767d64fb5af7714d7f3a62322
Autor:
Shin-ichiro Hattori, Nobuyo Higashi-Kuwata, Hironori Hayashi, Srinivasa Rao Allu, Jakka Raghavaiah, Haydar Bulut, Debananda Das, Brandon J. Anson, Emma K. Lendy, Yuki Takamatsu, Nobutoki Takamune, Naoki Kishimoto, Kazutaka Murayama, Kazuya Hasegawa, Mi Li, David A. Davis, Eiichi N. Kodama, Robert Yarchoan, Alexander Wlodawer, Shogo Misumi, Andrew D. Mesecar, Arun K. Ghosh, Hiroaki Mitsuya
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Here, using in vitro assays and structural analysis, the authors characterize the anti-SARS-CoV-2 properties of two small molcules, showing these to bind and target the virus main protease (Mpro), and to exhibit a synergistic antiviral effect when co
Externí odkaz:
https://doaj.org/article/86d3e81f7e794c15baedd9ad9a968412
Autor:
James, J. Anson, Aggarwal, Aneel K., Linden, R. Michael, Escalante, Carlos R., Petsko, Gregory A.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2004 Aug . 101(34), 12455-12460.
Externí odkaz:
https://www.jstor.org/stable/3373004
Autor:
Arun K. Ghosh, Dana Shahabi, Monika Yadav, Satish Kovela, Brandon J. Anson, Emma K. Lendy, Connie Bonham, Devika Sirohi, Carlos A. Brito-Sierra, Shin-ichiro Hattori, Richard Kuhn, Hiroaki Mitsuya, Andrew D. Mesecar
Publikováno v:
Molecules, Vol 26, Iss 19, p 5782 (2021)
We report the design and synthesis of a series of new 5-chloropyridinyl esters of salicylic acid, ibuprofen, indomethacin, and related aromatic carboxylic acids for evaluation against SARS-CoV-2 3CL protease enzyme. These ester derivatives were synth
Externí odkaz:
https://doaj.org/article/f42c479ac437463dac472853373f2de5
Akademický článek
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Publikováno v:
ACS Sensors. 5:3879-3891
Genetically encoded fluorescent sensors have been widely used to illuminate secretory vesicle dynamics and the vesicular lumen, including Zn2+ and pH, in living cells. However, vesicular sensors have a tendency to mislocalize and are susceptible to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42e891b1f5856bc627806ec7a33e1607
https://doi.org/10.1021/acssensors.0c01231
https://doi.org/10.1021/acssensors.0c01231
Publikováno v:
Journal of Advances in Information Technology. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ecaac0d8ed606e15305a5eda3c60105
https://doi.org/10.12720/jait.13.3.230-239
https://doi.org/10.12720/jait.13.3.230-239
Autor:
Brandon J. Anson, Dana Shahabi, Emma K. Lendy, Andrew D. Mesecar, Monika Yadav, Hiroaki Mitsuya, Jakka Raghavaiah, Nobuyo Higashi-Kuwata, Arun K. Ghosh, Shin-ichiro Hattori
Publikováno v:
Journal of Medicinal Chemistry
Here, we report the synthesis, structure-activity relationship studies, enzyme inhibition, antiviral activity, and X-ray crystallographic studies of 5-chloropyridinyl indole carboxylate derivatives as a potent class of SARS-CoV-2 chymotrypsin-like pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca6c8fd267d90963d17954b5da772e7
https://pubmed.ncbi.nlm.nih.gov/34528437
https://pubmed.ncbi.nlm.nih.gov/34528437
Autor:
Carlos A Brito-Sierra, Andrew D. Mesecar, Devika Sirohi, Satish Kovela, Monika Yadav, Hiroaki Mitsuya, Dana Shahabi, Emma K. Lendy, Arun K. Ghosh, Brandon J. Anson, Shinichiro Hattori, Richard J. Kuhn, Connie C. Bonham
Publikováno v:
Molecules
Molecules, Vol 26, Iss 5782, p 5782 (2021)
Volume 26
Issue 19
Molecules, Vol 26, Iss 5782, p 5782 (2021)
Volume 26
Issue 19
We report the design and synthesis of a series of new 5-chloropyridinyl esters of salicylic acid, ibuprofen, indomethacin, and related aromatic carboxylic acids for evaluation against SARS-CoV-2 3CL protease enzyme. These ester derivatives were synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da849073327a1c79bd9252806f46a20
https://pubmed.ncbi.nlm.nih.gov/34641337
https://pubmed.ncbi.nlm.nih.gov/34641337