Zobrazeno 1 - 10
of 88
pro vyhledávání: '"J. Andrew MacKay"'
Autor:
Shephali Kadam, Atham Ali, Mateusz Pospiech, Sandra Onyemaechi, Yiting Meng, Kanaka Dhuri, J. Andrew MacKay, Houda Alachkar
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117265- (2024)
CD99 is a transmembrane protein overexpressed in Acute Myeloid Leukemia (AML), presenting a potential novel therapeutic target. Our group has previously developed anti-CD99-A192 (α-CD99-A192), comprising of single chain variable fragment (scFv) and
Externí odkaz:
https://doaj.org/article/b97cc68ca9dc40bd8b5309fcead456b3
Autor:
Sara Aly Attia, Anh Tan Truong, Alvin Phan, Shin-Jae Lee, Manal Abanmai, Marinella Markanovic, Hugo Avila, Haozhong Luo, Atham Ali, Parameswaran G. Sreekumar, Ram Kannan, J. Andrew MacKay
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1817 (2023)
Background: Oxidative stress-induced retinal degeneration is among the main contributing factors of serious ocular pathologies that can lead to irreversible blindness. αB-crystallin (cry) is an abundant component of the visual pathway in the vitreou
Externí odkaz:
https://doaj.org/article/5deb9dd39dfd4dd2a098780ba9fea69d
Autor:
Jolinde van Strien, Hans Warmenhoven, Adrian Logiantara, Max Makurat, Lorenz Aglas, Athanasios Bethanis, Romain Leboux, Leonie van Rijt, J. Andrew MacKay, Johannes W. van Schijndel, Gregory Schneider, René Olsthoorn, Wim Jiskoot, Ronald van Ree, Alexander Kros
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
There is growing concern about the toxicity of colloidal aluminum salts used as adjuvants in subcutaneous allergen immunotherapy (SCIT). Therefore, alternative adjuvants and delivery systems are being explored to replace alum in SCIT. We applied mice
Externí odkaz:
https://doaj.org/article/ee4f7a6d5ac74d13b0074cd0865161f4
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6157 (2020)
Lacripep is a therapeutic peptide derived from the human tear protein, Lacritin. Lacripep interacts with syndecan-1 and induces mitogenesis upon the removal of heparan sulfates (HS) that are attached at the extracellular domain of syndecan-1. The pre
Externí odkaz:
https://doaj.org/article/fefea4a1f9a44e5787b61562baff69f9
Autor:
Pang-Yu Hsueh, Yaping Ju, Adrianna Vega, Maria C. Edman, J. Andrew MacKay, Sarah F. Hamm-Alvarez
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8, p 2758 (2020)
The autoimmune disorder, Sjögren’s syndrome (SS), is characterized by lymphocytic infiltration and loss of function of exocrine glands such as the lacrimal gland (LG) and salivary gland. SS-associated changes in the LG are associated with the deve
Externí odkaz:
https://doaj.org/article/f27886ad0b4d4a4d91d7ce4c467b347f
Publikováno v:
Pharmaceutics, Vol 11, Iss 5, p 221 (2019)
Contact lenses are widely prescribed for vision correction, and as such they are an attractive platform for drug delivery to the anterior segment of the eye. This manuscript explores a novel strategy to drive the reversible adsorption of peptide-base
Externí odkaz:
https://doaj.org/article/3c9bfe41a1f241b0ade1e7bd22776309
Publikováno v:
Biomacromolecules. 24:2030-2041
Autor:
Hugo Avila, Jingmei Yu, Geetha Boddu, Alvin Phan, Anh Truong, Santosh Peddi, Hao Guo, Shin-Jae Lee, Mario Alba, Ethan Canfield, Vicky Yamamoto, James C. Paton, Adrienne W. Paton, Amy S. Lee, J. Andrew MacKay
Publikováno v:
Biomacromolecules. 23(8)
Rapalogues are powerful therapeutic modalities for breast cancer; however, they suffer from low solubility and dose-limiting side effects. To overcome these challenges, we developed a long-circulating multiheaded drug carrier called 5FA, which contai
Publikováno v:
Adv Drug Deliv Rev
Antibodies possess multiple biologically relevant features that have been engineered into new therapeutic formats. Two examples include the adaptable specificity of their variable (Fv) region and the extension of plasma circulation times through thei
Autor:
Hao Guo, Yaping Ju, Minchang Choi, Maria C. Edman, Stan G. Louie, Sarah F. Hamm-Alvarez, J. Andrew MacKay
Publikováno v:
Biomaterials
Sjögren’s syndrome (SS) is a multifactorial autoimmune disease with principal symptoms including inflammation and loss of function of lacrimal glands (LG) and salivary glands. While glandular infiltrates includes both B- and T- cells, CD4+ T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb5925dadd931d04d960f28636b8f6d
https://europepmc.org/articles/PMC8982551/
https://europepmc.org/articles/PMC8982551/