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pro vyhledávání: '"J. Alf Davis"'
Autor:
Robin Marshall, Catherine Smyth, J. Alf Davis, Alasdair Garnett, Julian Scott Northen, John S. Carey, Stephen J. Byard, Urvish Pandya, Stephen John Martin, Antonio Codina, Gary Patrick Reid, John Mykytiuk, Sophie L. Berrell, Katherine Filer, Lesa Watson
Publikováno v:
Organic Process Research & Development. 23:762-770
This paper describes the process development conducted toward the multi-kilogram synthesis of a hemiadipic acid pro-drug of buprenorphine. The major challenges were to control the levels of the dibuprenorphine monoadipate impurity and to improve the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::878ee5f6f614c4c5a97ffeffdec68649
https://doi.org/10.1021/acs.oprd.9b00025
https://doi.org/10.1021/acs.oprd.9b00025
Publikováno v:
Enzyme and Microbial Technology. 33:743-748
A biotransformation procedure, using the filamentous fungus Cunninghamella echinulata NRRL 1384, for the high yielding regioselective demethylation of a thebaine derivative to give intermediates for the synthesis of buprenorphine is reported. The the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c48a56cc9b7d7f8f6c4dd77473c4983b
https://doi.org/10.1016/s0141-0229(03)00207-2
https://doi.org/10.1016/s0141-0229(03)00207-2
Publikováno v:
Biotechnology Letters. 24:1291-1294
A group of filamentous fungi from the genus Cunninghamella have been identified as potential biocatalysts in the generation of potential buprenorphine intermediates. A simple batch fermentation procedure results in the formation of dealkylated alkalo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee899f5eb4e6334ece5ac5f299473cb8
https://doi.org/10.1023/a:1016218211300
https://doi.org/10.1023/a:1016218211300
Publikováno v:
ChemInform. 33
A novel regiospecific N- to O-methyl transfer reaction has been characterised in the biotransformation of an N-CD3-thebaine derivative with the fungus Cunninghamella echinulata NRRL 1384.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3dcb8dbbb8fba254901c80115ede89d
https://doi.org/10.1002/chin.200250186
https://doi.org/10.1002/chin.200250186
Publikováno v:
Chemical communications (Cambridge, England). (16)
A novel regiospecific N- to O-methyl transfer reaction has been characterised in the biotransformation of an N-CD3-thebaine derivative with the fungus Cunninghamella echinulata NRRL 1384.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b517c88eed111582fce737abc5b23417
https://pubmed.ncbi.nlm.nih.gov/12196987
https://pubmed.ncbi.nlm.nih.gov/12196987
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