Zobrazeno 1 - 10
of 48
pro vyhledávání: '"J. Alex Pasternak"'
Publikováno v:
BMC Veterinary Research, Vol 20, Iss 1, Pp 1-13 (2024)
Abstract Background Hypothyroidism is a common endocrine disruption observed in utero that adversely affects fetal growth and maturation leading to long-term impacts on health; however, the exact molecular mechanisms by which these deleterious effect
Externí odkaz:
https://doaj.org/article/29f84585258641c3b5f3779b76c679d1
Autor:
Haesu Ko, J. Alex Pasternak, Margaret K. Mulligan, Glenn Hamonic, Naresh Ramesh, Daniel J. MacPhee, Graham S. Plastow, John C. S. Harding
Publikováno v:
BMC Veterinary Research, Vol 20, Iss 1, Pp 1-16 (2024)
Abstract Background Porcine reproductive and respiratory syndrome virus 2 (PRRSV-2) infection during late gestation substantially lowers fetal viability and survival. In a previous genome-wide association study, a single nucleotide polymorphism on ch
Externí odkaz:
https://doaj.org/article/58c5c4b33127490a98036b3ecad2030e
Publikováno v:
Physiological Reports, Vol 12, Iss 8, Pp n/a-n/a (2024)
Abstract Thyroid hormones regulate metabolic rate, nutrient utilization, growth, and development. Swine are susceptible to thyroid suppression in response to disease or environmental conditions, but the physiological impact of such disruption has not
Externí odkaz:
https://doaj.org/article/6f01a56d49034df1a665acc09bf6ee89
Publikováno v:
Veterinary Research, Vol 53, Iss 1, Pp 1-14 (2022)
Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) in late gestation causes a profound suppression of circulating maternal and fetal thyroid hormone during a critical window of development. To understand this relationship, we evalua
Externí odkaz:
https://doaj.org/article/0d1144fbd79b4957971c7f356aaca7cd
Autor:
Margaret K. Mulligan, Jocelyn E. Kleiman, Andrew C. Caldemeyer, John C. S. Harding, J. Alex Pasternak
Publikováno v:
Veterinary Research, Vol 53, Iss 1, Pp 1-14 (2022)
Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) infection during late gestation negatively affects fetal development. The objective of this study was to identify the fetal organs most severely impacted following infection, and ev
Externí odkaz:
https://doaj.org/article/5eb7e90db1814ed9b34dd99b52d8f9c7
Autor:
Carolina M. Malgarin, Fiona Moser, J. Alex Pasternak, Glenn Hamonic, Susan E. Detmer, Daniel J. MacPhee, John C. S. Harding
Publikováno v:
BMC Veterinary Research, Vol 17, Iss 1, Pp 1-14 (2021)
Abstract Background Mechanisms of fetal death following maternal PRRSV2 infection remain uncharacterized, although hypoxia from umbilical cord lesions and/or placental detachment due to apoptosis are hypothesized. We performed two experiments examini
Externí odkaz:
https://doaj.org/article/4302054c76e943c1aeec65c40821b847
Publikováno v:
Veterinary Research, Vol 51, Iss 1, Pp 1-14 (2020)
Abstract To better understand the host response to porcine reproductive and respiratory virus-2 (PRRSV2) we evaluated circulating thyroid hormone and associated gene expression in a late gestation challenge model. Pregnant gilts were inoculated at ge
Externí odkaz:
https://doaj.org/article/3aecafb3eb2f4cee87019f9eec6c78be
Autor:
Glenn Hamonic, J. Alex Pasternak, Siew Hon Ng, Kezia R. Fourie, Olena M. Simko, Brodie Deluco, Heather L. Wilson
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
To protect the health of sows and gilts, significant investments are directed toward the development of vaccines against infectious agents that impact reproduction. We developed an intrauterine vaccine that can be delivered with semen during artifici
Externí odkaz:
https://doaj.org/article/9029b57b55cb4a31bd8b6da904021845
Autor:
J. Alex Pasternak, Vaishnavi Iyer Aka Aiyer, Glenn Hamonic, A. Denise Beaulieu, Daniel A. Columbus, Heather L. Wilson
Publikováno v:
Toxins, Vol 10, Iss 1, p 40 (2018)
We intended to assess how exposure of piglets to deoxynivalenol (DON)-contaminated feed impacted their growth, immune response and gut development. Piglets were fed traditional Phase I, Phase II and Phase III diets with the control group receiving 0.
Externí odkaz:
https://doaj.org/article/5daf55165ab74798ae256d84edc89bf3
Publikováno v:
Mediators of Inflammation, Vol 2015 (2015)
Newborn piglets are immunologically naïve and must receive passive immunity via colostrum within 24 hours to survive. Mechanisms by which the newborn piglet gut facilitates uptake of colostral cells, antibodies, and proteins may include FcRn and pIg
Externí odkaz:
https://doaj.org/article/0d97ebb3972d48e093d3100701b9c761