Zobrazeno 1 - 10
of 20
pro vyhledávání: '"J. Agajanian"'
Autor:
Maritza Puray-Chavez, Kyle M. LaPak, Travis P. Schrank, Jennifer L. Elliott, Dhaval P. Bhatt, Megan J. Agajanian, Ria Jasuja, Dana Q. Lawson, Keanu Davis, Paul W. Rothlauf, Zhuoming Liu, Heejoon Jo, Nakyung Lee, Kasyap Tenneti, Jenna E. Eschbach, Christian Shema Mugisha, Emily M. Cousins, Erica W. Cloer, Hung R. Vuong, Laura A. VanBlargan, Adam L. Bailey, Pavlo Gilchuk, James E. Crowe, Jr., Michael S. Diamond, D. Neil Hayes, Sean P.J. Whelan, Amjad Horani, Steven L. Brody, Dennis Goldfarb, M. Ben Major, Sebla B. Kutluay
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109364- (2021)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) variants govern transmissibility, responsiveness to vaccination, and disease severity. In a screen for new models of SARS-CoV-2 infection, we identify human H522 lung ade
Externí odkaz:
https://doaj.org/article/fd7ca3003b0d4b6e81dd2ed8d532da99
Autor:
Megan J. Agajanian, Frances M. Potjewyd, Brittany M. Bowman, Smaranda Solomon, Kyle M. LaPak, Dhaval P. Bhatt, Jeffery L. Smith, Dennis Goldfarb, Alison D. Axtman, Michael B. Major
Publikováno v:
The Journal of biological chemistry. 298(6)
Aberrant activation or suppression of WNT/β-catenin signaling contributes to cancer initiation and progression, neurodegeneration, and bone disease. However, despite great need and more than 40 years of research, targeted therapies for the WNT pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426f24f2cd2a70cd5728daba1663d38f
https://pubmed.ncbi.nlm.nih.gov/35487243
https://pubmed.ncbi.nlm.nih.gov/35487243
Autor:
Brittany M. Bowman, Jeffrey L. Smith, Megan J. Agajanian, Alison D. Axtman, Dhaval P. Bhatt, Kyle M. LaPak, Smaranda Solomon, Michael B. Major, Frances Potjewyd, Dennis Goldfarb
The WNT/β-catenin signaling pathway is evolutionarily conserved and controls normal embryonic development, adult tissue homeostasis and regeneration. Aberrant activation or suppression of WNT signaling contributes to cancer initiation and progressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15bd8b9eb80c9f15983f687f1ef739f7
https://doi.org/10.1101/2021.11.30.470617
https://doi.org/10.1101/2021.11.30.470617
Autor:
Seth J. Weir, Tigist Y. Tamir, Priscila F. Siesser, Bernard E. Weissman, Trent Stohrer, M. Ben Major, Dennis Goldfarb, Brittany M. Bowman, Ryan M. Murphy, Kyle M. LaPak, Travis P. Schrank, Andrew E. Hale, Megan J. Agajanian, Nathaniel J. Moorman
Publikováno v:
J Cell Sci
Nuclear factor erythroid 2-related factor 2 (NFE2L2, also known as NRF2) is a transcription factor and master regulator of cellular antioxidant response. Aberrantly high NRF2-dependent transcription is recurrent in human cancer, but conversely NRF2 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893daee48fa4a46cf754fb568779223d
https://pubmed.ncbi.nlm.nih.gov/32546533
https://pubmed.ncbi.nlm.nih.gov/32546533
Autor:
F.J. Sorrell, Matthew P. Walker, Timothy M. Willson, A.S. Santiago, Opher Gileadi, James M. Bennett, Oleg Fedorov, Carina Gileadi, Alison D. Axtman, Susanne Müller, Serafin Ds, Michael B. Major, Meagan B. Ryan, Megan J. Agajanian, Rafael M. Couñago, Roberta R. Ruela-de-Sousa, David M. Graham, Nirav Kapadia, P.H.C. Godoi, Alex D. Rabinowitz, David H. Drewry, J.M. Elkins, Carrow I. Wells, William J. Zuercher
β-catenin-dependent WNT signal transduction governs normal development and adult tissue homeostasis. Inappropriate pathway activity mediates a vast array of human diseases, including bone density disorders, neurodegeneration and cancer. Although sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72833d6500a2dea075a8e06501f767c
https://doi.org/10.1101/258632
https://doi.org/10.1101/258632
Autor:
Carina Gileadi, Jonathan M. Elkins, Meagan B. Ryan, Matthew P. Walker, Melissa V. Gammons, James M. Bennett, Timothy M. Willson, David H. Drewry, Alison D. Axtman, Oleg Fedorov, Carrow I. Wells, Rafael M. Couñago, Alex D. Rabinowitz, Michael B. Major, A.S. Santiago, William J. Zuercher, Roberta R. Ruela-de-Sousa, David M. Graham, P.H.C. Godoi, Nirav Kapadia, Opher Gileadi, F.J. Sorrell, Megan J. Agajanian, Susanne Müller, D. Stephen Serafin
Publikováno v:
SSRN Electronic Journal.
β-catenin-dependent WNT signal transduction governs development, tissue homeostasis and a vast array of human diseases. Signal propagation through a WNT-Frizzled/LRP receptor complex requires clathrin-mediated endocytosis (CME). Paradoxically, CME a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e191023c5fff4ab5bfc701e3b3ad8934
https://doi.org/10.2139/ssrn.3188329
https://doi.org/10.2139/ssrn.3188329
Autor:
David H. Drewry, Carrow I. Wells, David M. Graham, Susanne Müller, P.H.C. Godoi, Roberta R. Ruela-de-Sousa, Nirav Kapadia, Matthew P. Walker, Megan J. Agajanian, Alex D. Rabinowitz, Fiona J. Sorrell, Meagan B. Ryan, James M. Bennett, Opher Gileadi, Alison D. Axtman, Timothy M. Willson, Tigist Y. Tamir, Yuko Nakamichi, Rafael M. Couñago, William J. Zuercher, Jonathan M. Elkins, D. Stephen Serafin, Michael B. Major, Melissa V. Gammons, Carina Gileadi, Oleg Fedorov, A.S. Santiago
Publikováno v:
Cell Reports
Summary β-Catenin-dependent WNT signal transduction governs development, tissue homeostasis, and a vast array of human diseases. Signal propagation through a WNT-Frizzled/LRP receptor complex requires proteins necessary for clathrin-mediated endocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44192008f344af1af0d43292bea0628
http://europepmc.org/articles/PMC6315376
http://europepmc.org/articles/PMC6315376